Protein Alignment nmo and MAPK10

DIOPT Version :10

• Sequence 1: NP_001356976.1
• Gene: nmo / 38890
• FlyBaseID: FBgn0011817
• Length: 439
• Species: Drosophila melanogaster
• Sequence 2: NP_001304998.1
• Gene: MAPK10 / 5602
• HGNCID: 6872
• Length: 478
• Species: Homo sapiens
• Alignment Length: 399
• Identity: 148/399 - (37%)
• Similarity: 217/399 - (54%)
• Gaps: 53/399 - (13%)

  Fly    44 RPIGYGAFGVVWAVTDPRDGRRVALKKLPNVFQSLVSSKRVFRELKMLCFFKHENVLSALDILQP 108
            :|||.||.|:|.|..|....|.||:|||...||:...:||.:|||.::....|:|::|.|::..|
Human    68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTP 132

  Fly   109 PH-LDFFQEIYVITELLQSDLHKIIVSPQHLSADH--IKVFLYQILRGLKYLHSARILHRDIKPG 170
            .. |:.||::|::.||:.::|.::|    .:..||  :...|||:|.|:|:||||.|:|||:||.
Human   133 QKTLEEFQDVYLVMELMDANLCQVI----QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPS 193

  Fly   171 NLLVNSNCVLKICDFGLARVEEPDQAKHMTQEVVTQYYRAPEILMGARHYSSAVDVWSVGCIFGE 235
            |::|.|:|.|||.||||||.  ...:..||..|||:||||||:::| ..|...||:||||||.||
Human   194 NIVVKSDCTLKILDFGLART--AGTSFMMTPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGE 255

  Fly   236 LLGRRILFQAQNPVQQLELITELLGTPTMEDMRHACEGARTHMLRRAPK------PPSF--SVLY 292
            ::..:|||..::.:.|...:.|.||||..|.|:......|.::..| ||      |..|  |:..
Human   256 MVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENR-PKYAGLTFPKLFPDSLFP 319

  Fly   293 TLSSH---ATHEAVHLLCQMLVFDPDKRISVTDALAHPYLDEGRLRYHSCMCKCCFTTSAGMRQY 354
            ..|.|   ...:|..||.:|||.||.|||||.|||.|||::   :.|.
Human   320 ADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN---VWYD----------------- 364

  Fly   355 TADFEPSAGQPFDDLWERKLTSVQQVKEEMHKFI---AEQLQTGRVPLCINPQSAAFKSFASSTV 416
            .|:.|....|.:|...:.:..::::.||.::|.:   .|:.:.|.|....:|..||..|..|
Human   365 PAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSES--- 426

  Fly   417 AHPSELPPS 425
                 ||||
Human   427 -----LPPS 430

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nmo	NP_001356976.1	STKc_NLK	39..411	CDD:173748	142/383 (37%)
MAPK10	NP_001304998.1	STKc_JNK	63..398	CDD:270840	136/357 (38%)