DRSC/TRiP Functional Genomics Resources

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Protein Alignment nmo and MAPK8

DIOPT Version :9

Sequence 1:NP_001356976.1 Gene:nmo / 38890 FlyBaseID:FBgn0011817 Length:439 Species:Drosophila melanogaster
Sequence 2:NP_001265476.1 Gene:MAPK8 / 5599 HGNCID:6881 Length:427 Species:Homo sapiens


Alignment Length:411 Identity:144/411 - (35%)
Similarity:216/411 - (52%) Gaps:62/411 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 RPIGYGAFGVVWAVTDPRDGRRVALKKLPNVFQSLVSSKRVFRELKMLCFFKHENVLSALDILQP 108
            :|||.||.|:|.|..|....|.||:|||...||:...:||.:|||.::....|:|::..|::..|
Human    30 KPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTP 94

  Fly   109 -PHLDFFQEIYVITELLQSDLHKIIVSPQHLSADH--IKVFLYQILRGLKYLHSARILHRDIKPG 170
             ..|:.||::|::.||:.::|.::|    .:..||  :...|||:|.|:|:||||.|:|||:||.
Human    95 QKSLEEFQDVYIVMELMDANLCQVI----QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPS 155

  Fly   171 NLLVNSNCVLKICDFGLARVEEPDQAKHMTQEVVTQYYRAPEILMGARHYSSAVDVWSVGCIFGE 235
            |::|.|:|.|||.||||||.  ...:..||..|||:||||||:::| ..|...||:||||||.||
Human   156 NIVVKSDCTLKILDFGLART--AGTSFMMTPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGE 217

  Fly   236 LLGRRILFQAQNPVQQLELITELLGTPTMEDMRHACEGARTHMLRRAPKPPSFS-------VLYT 293
            ::...:||...:.:.|...:.|.||||..|.|:......||::..| ||...:|       ||:.
Human   218 MIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENR-PKYAGYSFEKLFPDVLFP 281

  Fly   294 LSSH----ATHEAVHLLCQMLVFDPDKRISVTDALAHPYLDEGRLRYHSCMCKCCFTTSAGMRQY 354
            ..|.    ...:|..||.:|||.|..|||||.:||.|||::                        
Human   282 ADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYIN------------------------ 322

  Fly   355 TADFEPSAGQ------PFDDLWERKLTSVQQVKEEMHKFI---AEQLQTGRVPLCINPQSAAF-- 408
             ..::||..:      |...|.||:.| :::.||.::|.:   .|:.:.|.:....:|..||.  
Human   323 -VWYDPSEAEAPPPKIPDKQLDEREHT-IEEWKELIYKEVMDLEERTKNGVIRGQPSPLGAAVIN 385

  Fly   409 ---KSFASSTVAHPSELPPSP 426
               ...:||:|...|.:...|
Human   386 GSQHPSSSSSVNDVSSMSTDP 406

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nmoNP_001356976.1 STKc_NLK 39..411 CDD:173748 139/394 (35%)
MAPK8NP_001265476.1 STKc_JNK 25..360 CDD:270840 134/363 (37%)
TXY 183..185 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 371..427 8/36 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165143080
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D741207at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.850

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