DRSC/TRiP Functional Genomics Resources

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Protein Alignment nmo and MAPK1

DIOPT Version :9

Sequence 1:NP_001356976.1 Gene:nmo / 38890 FlyBaseID:FBgn0011817 Length:439 Species:Drosophila melanogaster
Sequence 2:NP_002736.3 Gene:MAPK1 / 5594 HGNCID:6871 Length:360 Species:Homo sapiens


Alignment Length:391 Identity:149/391 - (38%)
Similarity:224/391 - (57%) Gaps:47/391 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 LVQGGAAGGAPQGASAILAAAAPYYQPPAVPQDVQPDRPIGYGAFGVVWAVTDPRDGRRVALKKL 71
            :....|||..|:.....:....|.|...:.         ||.||:|:|.:..|..:..|||:||:
Human     1 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSY---------IGEGAYGMVCSAYDNVNKVRVAIKKI 56

  Fly    72 PNVFQSLVSSKRVFRELKMLCFFKHENVLSALDILQPPHLDFFQEIYVITELLQSDLHKIIVSPQ 136
             :.|:.....:|..||:|:|..|:|||::...||::.|.::..:::|::.:|:::||:|:: ..|
Human    57 -SPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLL-KTQ 119

  Fly   137 HLSADHIKVFLYQILRGLKYLHSARILHRDIKPGNLLVNSNCVLKICDFGLARVEEP--DQAKHM 199
            |||.|||..|||||||||||:|||.:||||:||.|||:|:.|.|||||||||||.:|  |....:
Human   120 HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFL 184

  Fly   200 TQEVVTQYYRAPEILMGARHYSSAVDVWSVGCIFGELLGRRILFQAQNPVQQLELITELLGTPTM 264
            |:.|.|::||||||::.::.|:.::|:||||||..|:|..|.:|..::.:.||..|..:||:|:.
Human   185 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 249

  Fly   265 EDMRHACE-GARTHMLRRAPKPPSFSVLYT-LSSHATHEAVHLLCQMLVFDPDKRISVTDALAHP 327
            ||:..... .||.::|   ..|....|.:. |..:|..:|:.||.:||.|:|.|||.|..|||||
Human   250 EDLNCIINLKARNYLL---SLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHP 311

  Fly   328 YLDEGRLRYHSCMCKCCFTTSAGMRQYTADFEPSAGQPF------DDLWERKLTSVQQVKEEMHK 386
            ||::                     .|....||.|..||      |||.:.||..:  :.||..:
Human   312 YLEQ---------------------YYDPSDEPIAEAPFKFDMELDDLPKEKLKEL--IFEETAR 353

  Fly   387 F 387
            |
Human   354 F 354

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
nmoNP_001356976.1 STKc_NLK 39..411 CDD:173748 143/359 (40%)
MAPK1NP_002736.3 STKc_ERK1_2_like 19..353 CDD:270839 144/370 (39%)
Inhibitor-binding 105..108 0/2 (0%)