DRSC/TRiP Functional Genomics Resources

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Protein Alignment nmo and NLK

DIOPT Version :9

Sequence 1:NP_001356976.1 Gene:nmo / 38890 FlyBaseID:FBgn0011817 Length:439 Species:Drosophila melanogaster
Sequence 2:NP_057315.3 Gene:NLK / 51701 HGNCID:29858 Length:527 Species:Homo sapiens


Alignment Length:425 Identity:325/425 - (76%)
Similarity:368/425 - (86%) Gaps:6/425 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 GAAGGAPQGASAILAAA--APYYQPPAVPQ---DVQPDRPIGYGAFGVVWAVTDPRDGRRVALKK 70
            |.|..||....|..||.  |.::|....||   |::||||||||||||||:|||||||:||||||
Human   104 GPAAAAPAQVQAAAAATVKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKK 168

  Fly    71 LPNVFQSLVSSKRVFRELKMLCFFKHENVLSALDILQPPHLDFFQEIYVITELLQSDLHKIIVSP 135
            :|||||:|||.|||||||||||||||:|||||||||||||:|:|:||||:|||:|||||||||||
Human   169 MPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSP 233

  Fly   136 QHLSADHIKVFLYQILRGLKYLHSARILHRDIKPGNLLVNSNCVLKICDFGLARVEEPDQAKHMT 200
            |.||:||:|||||||||||||||||.|||||||||||||||||||||||||||||||.|:::|||
Human   234 QPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMT 298

  Fly   201 QEVVTQYYRAPEILMGARHYSSAVDVWSVGCIFGELLGRRILFQAQNPVQQLELITELLGTPTME 265
            ||||||||||||||||:||||:|:|:|||||||.||||||||||||:|:|||:|||:|||||::|
Human   299 QEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLE 363

  Fly   266 DMRHACEGARTHMLRRAPKPPSFSVLYTLSSHATHEAVHLLCQMLVFDPDKRISVTDALAHPYLD 330
            .||.|||||:.|:||...|.||..|||||||.||||||||||:||||||.||||..|||||||||
Human   364 AMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLD 428

  Fly   331 EGRLRYHSCMCKCCFTTSAGMRQYTADFEPSAGQPFDDLWERKLTSVQQVKEEMHKFIAEQLQTG 395
            |||||||:|||||||:||.| |.||:||||.....|||.:|:.|:||:||||.:|:||.||.:..
Human   429 EGRLRYHTCMCKCCFSTSTG-RVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILEQQKGN 492

  Fly   396 RVPLCINPQSAAFKSFASSTVAHPSELPPSPHQWE 430
            ||||||||||||||||.|||||.|||:||||..||
Human   493 RVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE 527

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nmoNP_001356976.1 STKc_NLK 39..411 CDD:173748 298/371 (80%)
NLKNP_057315.3 Required for interaction with TAB2. /evidence=ECO:0000250 1..304 156/199 (78%)
Sufficient for interaction with DAPK3. /evidence=ECO:0000269|PubMed:21454679 1..125 8/20 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 22..72
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 90..140 12/35 (34%)
Sufficient for interaction with DAPK3. /evidence=ECO:0000269|PubMed:21454679 124..416 235/291 (81%)
STKc_NLK 137..508 CDD:173748 298/371 (80%)
TQE 298..300 1/1 (100%)
Required for homodimerization and kinase activation and localization to the nucleus. /evidence=ECO:0000250 428..527 69/99 (70%)
Required for interaction with TAB2. /evidence=ECO:0000250 434..527 63/93 (68%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165143084
Domainoid 1 1.000 504 1.000 Domainoid score I333
eggNOG 1 0.900 - - E1_KOG0664
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H88836
Inparanoid 1 1.050 663 1.000 Inparanoid score I766
Isobase 1 0.950 - 0 Normalized mean entropy S657
OMA 1 1.010 - - QHG47979
OrthoDB 1 1.010 - - D309855at33208
OrthoFinder 1 1.000 - - FOG0005673
OrthoInspector 1 1.000 - - oto89347
orthoMCL 1 0.900 - - OOG6_107580
Panther 1 1.100 - - O PTHR24055
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2681
SonicParanoid 1 1.000 - - X4072
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

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