Protein Alignment nmo and Nlk

DIOPT Version :10

• Sequence 1: NP_001356976.1
• Gene: nmo / 38890
• FlyBaseID: FBgn0011817
• Length: 439
• Species: Drosophila melanogaster
• Sequence 2: NP_001178853.1
• Gene: Nlk / 497961
• RGDID: 1561602
• Length: 527
• Species: Rattus norvegicus
• Alignment Length: 425
• Identity: 325/425 - (76%)
• Similarity: 368/425 - (86%)
• Gaps: 6/425 - (1%)

  Fly    11 GAAGGAPQGASAILAAA--APYYQPPAVPQ---DVQPDRPIGYGAFGVVWAVTDPRDGRRVALKK 70
            |.|..||....|..||.  |.::|....||   |::||||||||||||||:|||||||:||||||
  Rat   104 GPAAAAPAQVQAAAAATVKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKK 168

  Fly    71 LPNVFQSLVSSKRVFRELKMLCFFKHENVLSALDILQPPHLDFFQEIYVITELLQSDLHKIIVSP 135
            :|||||:|||.|||||||||||||||:|||||||||||||:|:|:||||:|||:|||||||||||
  Rat   169 MPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSP 233

  Fly   136 QHLSADHIKVFLYQILRGLKYLHSARILHRDIKPGNLLVNSNCVLKICDFGLARVEEPDQAKHMT 200
            |.||:||:|||||||||||||||||.|||||||||||||||||||||||||||||||.|:::|||
  Rat   234 QPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMT 298

  Fly   201 QEVVTQYYRAPEILMGARHYSSAVDVWSVGCIFGELLGRRILFQAQNPVQQLELITELLGTPTME 265
            ||||||||||||||||:||||:|:|:|||||||.||||||||||||:|:|||:|||:|||||::|
  Rat   299 QEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLE 363

  Fly   266 DMRHACEGARTHMLRRAPKPPSFSVLYTLSSHATHEAVHLLCQMLVFDPDKRISVTDALAHPYLD 330
            .||.|||||:.|:||...|.||..|||||||.||||||||||:||||||.||||..|||||||||
  Rat   364 AMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLD 428

  Fly   331 EGRLRYHSCMCKCCFTTSAGMRQYTADFEPSAGQPFDDLWERKLTSVQQVKEEMHKFIAEQLQTG 395
            |||||||:|||||||:||.| |.||:||||.....|||.:|:.|:||:||||.:|:||.||.:..
  Rat   429 EGRLRYHTCMCKCCFSTSTG-RVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILEQQKGN 492

  Fly   396 RVPLCINPQSAAFKSFASSTVAHPSELPPSPHQWE 430
            ||||||||||||||||.|||||.|||:||||..||
  Rat   493 RVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nmo	NP_001356976.1	STKc_NLK	39..411	CDD:173748	298/371 (80%)
Nlk	NP_001178853.1	Required for interaction with TAB2. /evidence=ECO:0000250|UniProtKB:O54949	1..304		156/199 (78%)
		Sufficient for interaction with DAPK3. /evidence=ECO:0000250|UniProtKB:Q9UBE8	1..125		8/20 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..72
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	90..139		12/34 (35%)
		Sufficient for interaction with DAPK3. /evidence=ECO:0000250|UniProtKB:Q9UBE8	124..416		235/291 (81%)
		STKc_NLK	137..508	CDD:173748	298/371 (80%)
		TQE	298..300		1/1 (100%)
		Required for homodimerization and kinase activation and localization to the nucleus. /evidence=ECO:0000250|UniProtKB:O54949	428..527		69/99 (70%)
		Required for interaction with TAB2. /evidence=ECO:0000250|UniProtKB:O54949	434..527		63/93 (68%)