Protein Alignment nmo and MAPK14

DIOPT Version :10

• Sequence 1: NP_001356976.1
• Gene: nmo / 38890
• FlyBaseID: FBgn0011817
• Length: 439
• Species: Drosophila melanogaster
• Sequence 2: XP_011512612.2
• Gene: MAPK14 / 1432
• HGNCID: 6876
• Length: 401
• Species: Homo sapiens
• Alignment Length: 345
• Identity: 144/345 - (41%)
• Similarity: 203/345 - (58%)
• Gaps: 39/345 - (11%)

  Fly    56 AVTDPRDGRRVALKKLPNVFQSLVSSKRVFRELKMLCFFKHENVLSALDILQPPH-LDFFQEIYV 119
            |..|.:.|.|||:|||...|||::.:||.:|||::|...|||||:..||:..|.. |:.|.::|:
Human    81 AAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYL 145

  Fly   120 ITELLQSDLHKIIVSPQHLSADHIKVFLYQILRGLKYLHSARILHRDIKPGNLLVNSNCVLKICD 184
            :|.|:.:||:. ||..|.|:.||::..:|||||||||:|||.|:|||:||.||.||.:|.|||.|
Human   146 VTHLMGADLNN-IVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILD 209

  Fly   185 FGLARVEEPDQAKHMTQEVVTQYYRAPEILMGARHYSSAVDVWSVGCIFGELLGRRILFQAQNPV 249
            |||||..:.:    ||..|.|::||||||::...||:..||:||||||..|||..|.||...:.:
Human   210 FGLARHTDDE----MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHI 270

  Fly   250 QQLELITELLGTPTMEDMRH-ACEGARTHM--LRRAPKPPSFSVLYTLSSHATHEAVHLLCQMLV 311
            .||:||..|:|||..|.::. :.|.||.::  |.:.|| .:|:.::.   .|...||.||.:|||
Human   271 DQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPK-MNFANVFI---GANPLAVDLLEKMLV 331

  Fly   312 FDPDKRISVTDALAHPYLDEGRLRYHSCMCKCCFTTSAGMRQYTADFEPSAGQPFDDLWERKLTS 376
            .|.||||:...||||.|.    .:||.                 .|.||.| .|:|..:|.:...
Human   332 LDSDKRITAAQALAHAYF----AQYHD-----------------PDDEPVA-DPYDQSFESRDLL 374

  Fly   377 VQQVK----EEMHKFIAEQL 392
            :.:.|    :|:..|:...|
Human   375 IDEWKSLTYDEVISFVPPPL 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nmo	NP_001356976.1	STKc_NLK	39..411	CDD:173748	144/345 (42%)
MAPK14	XP_011512612.2	Protein Kinases, catalytic domain	57..391	CDD:473864	143/340 (42%)