Protein Alignment nmo and Mapk7

DIOPT Version :10

• Sequence 1: NP_001356976.1
• Gene: nmo / 38890
• FlyBaseID: FBgn0011817
• Length: 439
• Species: Drosophila melanogaster
• Sequence 2: NP_001178476.1
• Gene: Mapk7 / 114509
• RGDID: 621505
• Length: 812
• Species: Rattus norvegicus
• Alignment Length: 395
• Identity: 161/395 - (40%)
• Similarity: 238/395 - (60%)
• Gaps: 43/395 - (10%)

  Fly    46 IGYGAFGVVWAVTDPRDGRRVALKKLPNVFQSLVSSKRVFRELKMLCFFKHENVLSALDILQP-- 108
            ||.||:|||.:......|::||:||:||.|..:.::||..||||:|..|||:|:::..|||:|
  Rat    61 IGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTV 125

  Fly   109 PHLDFFQEIYVITELLQSDLHKIIVSPQHLSADHIKVFLYQILRGLKYLHSARILHRDIKPGNLL 173
            |:.: |:.:||:.:|::||||:||.|.|.|:.:|::.||||:||||||:|||:::|||:||.|||
  Rat   126 PYGE-FRSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLL 189

  Fly   174 VNSNCVLKICDFGLARVEEPDQAKH---MTQEVVTQYYRAPEILMGARHYSSAVDVWSVGCIFGE 235
            ||.||.|||.|||:||......|:|   ||:.|.|::|||||:::....|:.|:|:|||||||||
  Rat   190 VNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGE 254

  Fly   236 LLGRRILFQAQNPVQQLELITELLGTPTMEDMRH-ACEGARTHMLRRAPKPP-SFSVLYTLSSHA 298
            :|.||.||..:|.|.||:||..:||||:...::. ..|..|.::....|:.| .:..:|   ..|
  Rat   255 MLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVY---PGA 316

  Fly   299 THEAVHLLCQMLVFDPDKRISVTDALAHPYLDEGRLRYHSCMCKCCFTTSAGMRQYTADFEPSAG 363
            ..:|:.||.:||.|:|..|||...||.||:|    .:||.                 .|.||...
  Rat   317 DRQALSLLGRMLRFEPSARISAAAALRHPFL----AKYHD-----------------PDDEPDCA 360

  Fly   364 QPFDDLWERKLTSVQQVKE----EMHKFIAEQLQTGRVPLCINPQSAAFKSFASSTVAHPSELPP 424
            .|||..::|:..:.:::||    |:..|.|.: :..|..:...|   :.:..||..|....|: |
  Rat   361 PPFDFAFDREALTRERIKEAIVAEIEDFHARR-EGIRQQIRFQP---SLQPVASEPVCPDVEM-P 420

  Fly   425 SPHQW 429
            ||  |
  Rat   421 SP--W 423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nmo	NP_001356976.1	STKc_NLK	39..411	CDD:173748	153/375 (41%)
Mapk7	NP_001178476.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		Required for cytoplasmic targeting. /evidence=ECO:0000250	2..77		7/15 (47%)
		STKc_ERK5	49..384	CDD:270842	148/347 (43%)
		Required for binding to MAP2K5. /evidence=ECO:0000250	78..139		27/61 (44%)
		Necessary for oligomerization. /evidence=ECO:0000250	140..406		118/293 (40%)
		TXY. /evidence=ECO:0000250	219..221		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	424..475		161/395 (41%)
		Nuclear localization signal. /evidence=ECO:0000250	505..539