Protein Alignment nmo and CDK2

DIOPT Version :10

• Sequence 1: NP_001356976.1
• Gene: nmo / 38890
• FlyBaseID: FBgn0011817
• Length: 439
• Species: Drosophila melanogaster
• Sequence 2: XP_011536034.1
• Gene: CDK2 / 1017
• HGNCID: 1771
• Length: 346
• Species: Homo sapiens
• Alignment Length: 367
• Identity: 118/367 - (32%)
• Similarity: 169/367 - (46%)
• Gaps: 105/367 - (28%)

  Fly    38 QDVQPDRPIGYGAFGVVWAVTDPRDGRRVALKKLPNVFQSLVSSKRVFRELKMLCFFKHENVLSA 102
            ::.|....||.|.:|||:...:...|..|||||:....::........||:.:|....|.|::..
Human     2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKL 66

  Fly   103 LDILQPPHLDFFQEIYVITELLQSDLHKIIVS------PQHLSADHIKVFLYQILRGLKYLHSAR 161
            ||::   |.:  .::|::.|.|..||.|.:.:      |..|    ||.:|:|:|:||.:.||.|
Human    67 LDVI---HTE--NKLYLVFEFLHQDLKKFMDASALTGIPLPL----IKSYLFQLLQGLAFCHSHR 122

  Fly   162 ILHRDIKPGNLLVNSNCVLKICDFGLARV-EEPDQAKHMTQEVVTQYYRAPEILMGARHYSSAVD 225
            :||||:||.|||:|:...:|:.||||||. ..|  .:..|.||||.:|||||||:|.::||:|||
Human   123 VLHRDLKPQNLLINTEGAIKLADFGLARAFGVP--VRTYTHEVVTLWYRAPEILLGCKYYSTAVD 185

  Fly   226 VWSVGCIFGE--LLG----------------------------------------------RRIL 242
            :||:||||.|  |:|                                              ||.|
Human   186 IWSLGCIFAEMHLVGTQHHARCCGEHRRNGRQSLCPLCSYLEVAASQGWGMTAVSTPYPVTRRAL 250

  Fly   243 FQAQNPVQQLELITELLGTP---------TMEDMRHACEGARTHMLRRAPKPPSF---------S 289
            |...:.:.||..|...||||         :|.|.:                 |||         .
Human   251 FPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK-----------------PSFPKWARQDFSK 298

  Fly   290 VLYTLSSHATHEAVHLLCQMLVFDPDKRISVTDALAHPYLDE 331
            |:..|.    .:...||.|||.:||:||||...|||||:..:
Human   299 VVPPLD----EDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 336

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nmo	NP_001356976.1	STKc_NLK	39..411	CDD:173748	118/366 (32%)
CDK2	XP_011536034.1	STKc_CDK2_3	3..334	CDD:270844	118/362 (33%)