DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KRT83 and si:dkey-183i3.5

DIOPT Version :9

Sequence 1:	NP_002273.3	Gene:	KRT83 / 3889	HGNCID:	6460	Length:	493	Species:	Homo sapiens
Sequence 2:	NP_001373183.1	Gene:	si:dkey-183i3.5 / 566445	ZFINID:	ZDB-GENE-030131-8568	Length:	589	Species:	Danio rerio

Alignment Length:	517	Identity:	132/517 - (25%)
Similarity:	232/517 - (44%)	Gaps:	86/517 - (16%)

- Green bases have known domain annotations that are detailed below.

Human     8 IGCGFRPGNFSCVSACGPRPSRCCITAAPYRGISCYRGLTGGF----GSHSVCGGFRAGSCG-RS 67
            :|.||..|                  |....|.....||.||.    |...:.||...|:.| |:
Zfish    50 LGLGFGAG------------------AGAVAGAGAGLGLGGGSLALGGGLGLGGGLGLGAGGARA 96

Human    68 FGYRSG---------------GVCGPSPPCITTVSVNESLLTPLNLEIDPN------AQCVKQEE 111
            .|.|:|               |..|.:|..|::.:..::.::|:. .|||:      .|..:.:|
Zfish    97 AGVRAGVAHLRSHLGGRVFKIGGYGFNPSFISSTTTVDAGVSPMP-SIDPSLPSPDTVQVTRMKE 160

Human   112 KEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQ---SNLEPLFAGYIETLRREAEC 173
            ||::::||.:||:||||.|.|||.|.:|..|:..:.|.|  |   :|...|....|...:.:.:.
Zfish   161 KEELQALNDKFASFIDKARSLEQHNAVLRAKISMFTNPE--QGGPANTSVLLTSAIGAYKSQIDS 223

Human   174 VEADSGRLASELNHVQEVLEGYKKKYEEEVALRATAENEFVALKKDVDCAYLRKSDLEANVEALI 238
            :.:....:.:|:.|.:.::|..:.:||||.:...:.|.::.|||::||..||...:|:.::..|.
Zfish   224 LSSTKEAIIAEIEHFKAIIEDDQARYEEETSQTKSLELDWTALKEEVDNLYLTLFELQTSICGLE 288

Human   239 QEIDFLRRLYE---EEIRILQSHISDTSVVVKLDNSRDL-NMDCIVAEIKAQYDDIATRSRAEAE 299
            .:|...:::|:   :|:|.:.:....::|.:.:||:... ::...:.|:||.|:.:|.||:.||.
Zfish   289 DQIALSKQVYDAKVKEVRTIVTGGVKSAVSISVDNAAQAQDLTSALTEVKAHYETLAQRSKQEAL 353

Human   300 SWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSEQQGEA 364
            ...:.....|..:.....:||...|:|:......|..:..|:|..|..|.:||:.|.::|....:
Zfish   354 VSVQDSLSMMSVSSQPSSQTLTSAKDELRAYKLQIDSVQREIERLKSLNLQLESQVEEAECHSNS 418

Human   365 ALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEGVEAV 429
            .....:.::..|:..|...::.:....:||||::.||:.||:||..|::||:.||.||..|
Zfish   419 HTETYQDQVLTLKSQLDDLRKQITQYGQEYQELLASKMSLDVEITAYKKLLDSEENRLKSG---- 479

Human   430 NVCVSSSRGGVVCGDLCVSGSRPVTGSVCSAPCNGNLVVSTGLCKPCGQLNTTCGGGSCGQG 491
                    |||.     |..|:.:.|               |.....|.|....||...|.|
Zfish   480 --------GGVT-----VHMSKTLLG---------------GGAGGAGGLGAGAGGAGLGGG 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KRT83	NP_002273.3	Head	1..111		28/128 (22%)
		Keratin_2_head	4..107	CDD:292825	28/124 (23%)
		Filament	110..421	CDD:278467	88/317 (28%)
		Coil 1A	112..146		17/33 (52%)
		Linker 1	147..156		3/11 (27%)
		Coil 1B	157..257		23/102 (23%)
		BAR	235..425	CDD:299863	50/193 (26%)
		Linker 12	258..274		3/15 (20%)
		Coil 2	275..418		38/142 (27%)
		RILP-like	<320..>388	CDD:304877	14/67 (21%)
		Tail	419..493		17/73 (23%)
si:dkey-183i3.5	NP_001373183.1	Filament	160..475	CDD:365827	88/316 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28N6C
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46601
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920