DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8042 and Ubxn4

DIOPT Version :9

Sequence 1:	NP_648165.1	Gene:	CG8042 / 38886	FlyBaseID:	FBgn0027554	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	NP_001343458.1	Gene:	Ubxn4 / 67812	MGIID:	1915062	Length:	507	Species:	Mus musculus

Alignment Length:	681	Identity:	191/681 - (28%)
Similarity:	281/681 - (41%)	Gaps:	201/681 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNWHKGNIAEAVAASKAKGAVFVVFIEGQDEMTRKLERFVDDSQVRSRLETSDFVAIKVQGNSSA 65
            |.|.:|.|..|:|::|..|||||||:.|.||.:.::....:|.:| ::..:::|||||:...|.|
Mouse     1 MLWFQGAIPAAIASAKRSGAVFVVFVAGDDEQSIQMAASWEDEKV-TQASSNNFVAIKIDTKSEA 64

  Fly    66 YGQFMSLYKIVPIPSLFFIGKTGTPLEIATGVTASVDELTEKIDKVLILAGKRTEPVAASSSSCA 130
            ..||..:|.:|.:||.||||.:|.|||:..| :.|.|||..:|.||..:
Mouse    65 CLQFSQIYPVVCVPSSFFIGDSGIPLEVIAG-SVSADELVTRIHKVQQM---------------- 112

  Fly   131 KTLDPNEVRSFAGADGSSSTGESQVVQTASENFRDPETTSVSNSPTGGVEEAKTNPPNSPVAASL 195
                            .||.||:.|.       .|.::.|..::|:...|......|.|. ...|
Mouse   113 ----------------HSSKGEASVT-------NDNQSESSVSTPSASFEPDVCENPESK-NTEL 153

  Fly   196 ASIPAAVSTSSLEGKSGSEAEAASPTALAAEKRAAASKVEGSATTSGAAARNFATNNLIPAVPLM 260
            ...||   ||..:..:.:..|.....:.:.|....::
Mouse   154 CETPA---TSDTKSDTATGGECTGHDSHSQEPHGCSN---------------------------- 187

  Fly   261 TPAVPVPTQRPLEAQDNT-ESEERLAEVRNILEQKRKERVEEEKRMEKENELRRRRDGREAQSQQ 324
                    |||  |:|.| ..|.||.:.   ||::|:|:.:||.:.|.:.|:.||:.|:|....:
Mouse   188 --------QRP--AEDLTVRVESRLTKK---LEERREEKRKEEAQREIKKEIERRKTGKEMLDYK 239

  Fly   325 ARAKEQELKNMQEQIKRERQEELAARERIRAQIAADRAEQAQRFNTPDISSTTNSVAATAASNVI 389
            .:.:|:..|.|.|:..||:.|:.||||||:.|||.||||:|.||     :.|..:.||.||: ::
Mouse   240 RKQEEELTKRMLEERSREKAEDRAARERIKQQIALDRAERAARF-----AKTKEAEAAKAAA-LL 298

  Fly   390 TTDASVSSVDET---------RLQIRLPGGIQRTKSFPAGEVLATVRVYVRNEMLAASDVRDFTL 445
            |..|......|:         |:|.|||.|...|..||:...|...|.:....:  .:...:|:|
Mouse   299 TKQAGTEVKRESTARDRSTIARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQTV--GNTYGNFSL 361

  Fly   446 ATSYPRREFQTEDEVKTLNELNLVPNAVVLVLT--KEQVNRVVQSGGSLMTMLGTV------IWA 502
            ||.:|||||..||..:.|.:|.|.|:|.|::|.  :...:.|..|.|.:.|:||||      ||.
Mouse   362 ATMFPRREFTREDYKRRLLDLELAPSASVVLLPAGRPATSIVHSSSGDIWTLLGTVLYPFLAIWR 426

  Fly   503 LLTPAAKAFDYINKMGLRPLTQKLSVFMANFRWPGQRAGLEVYQGDAAARRNMDMFSLRPTPAPG 567
            |:                          :||                       :|| .|.||
Mouse   427 LI--------------------------SNF-----------------------LFS-NPPPA-- 439

  Fly   568 YEYDGASTEQTGGSAERPTPQNQPGPGNTPPAHNTSQASASQSQQFQQRP--------GGYQPPK 624
                     ||...|....|.|                |||.|:..::.|        .|....|
Mouse   440 ---------QTSARATSTEPSN----------------SASSSKSEKREPVRKRMLEKRGEDFKK 479

  Fly   625 YGDSNIRRLQDTKKDEKDKDKATYNGNSTQQ 655
            .|.....|.||..:||.:    |:|||||||
Mouse   480 EGKIYRLRTQDDGEDENN----TWNGNSTQQ 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8042	NP_648165.1	DUF3682	170..337	CDD:289231	36/167 (22%)
		GBP_C	<272..367	CDD:303769	39/95 (41%)
		coiled coil	342..353	CDD:293879	6/10 (60%)
		UBQ	399..476	CDD:294102	29/85 (34%)
Ubxn4	NP_001343458.1	Interaction with UBQLN1. /evidence=ECO:0000250\|UniProtKB:Q92575	1..199		72/280 (26%)
		Thioredoxin_like	4..113	CDD:320948	46/142 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..194		22/164 (13%)
		UBX	319..394	CDD:197552	28/76 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	438..507		28/100 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5701
eggNOG	1	0.900	-	-		E1_KOG2507
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	218	1.000	Inparanoid score	I3576
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60095
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007457
OrthoInspector	1	1.000	-	-		oto93340
orthoMCL	1	0.900	-	-		OOG6_105479
Panther	1	1.100	-	-	LDO	PTHR46424
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2329
SonicParanoid	1	1.000	-	-		X6332
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.860