DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8042 and UBXN4

DIOPT Version :10

Sequence 1:NP_648165.1 Gene:CG8042 / 38886 FlyBaseID:FBgn0027554 Length:656 Species:Drosophila melanogaster
Sequence 2:NP_055422.1 Gene:UBXN4 / 23190 HGNCID:14860 Length:508 Species:Homo sapiens


Alignment Length:683 Identity:194/683 - (28%)
Similarity:282/683 - (41%) Gaps:204/683 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MNWHKGNIAEAVAASKAKGAVFVVFIEGQDEMTRKLERFVDDSQVRSRLETSDFVAIKVQGNSSA 65
            |.|.:|.|..|:|.:|..|||||||:.|.||.:.::....:|.:| :...::.|||||:...|.|
Human     1 MLWFQGAIPAAIATAKRSGAVFVVFVAGDDEQSTQMAASWEDDKV-TEASSNSFVAIKIDTKSEA 64

  Fly    66 YGQFMSLYKIVPIPSLFFIGKTGTPLEIATGVTASVDELTEKIDKVLILAGKRTEPVAASSSSCA 130
            ..||..:|.:|.:||.||||.:|.|||:..| :.|.|||..:|.||      |...:..|.:|. 
Human    65 CLQFSQIYPVVCVPSSFFIGDSGIPLEVIAG-SVSADELVTRIHKV------RQMHLLKSETSV- 121

  Fly   131 KTLDPNEVRSFAGADGSSSTGESQVVQTASENFRDPETTSVSNSPTGGVEEAKTNPPNSPVAASL 195
                         |:||.|  ||.|           .|.|.|..|....|.:::.      .|.|
Human   122 -------------ANGSQS--ESSV-----------STPSASFEPNNTCENSQSR------NAEL 154

  Fly   196 ASIPAAVSTSSLEGKSGSEAEAASPTALAAEKRAAASKVEGSATTSGAAARNFATNNLIPAVPLM 260
            ..||....|.|.....|..|                    |.||:|                   
Human   155 CEIPPTSDTKSDTATGGESA--------------------GHATSS------------------- 180

  Fly   261 TPAVPVPTQRPLEAQDNTESEE---RLAEVRNILEQKRKERVEEEKRMEKENELRRRRDGREAQS 322
                    |.|....|...:|:   |:..:...||::|:|:.:||::.|.:.|:.||:.|:|...
Human   181 --------QEPSGCSDQRPAEDLNIRVERLTKKLEERREEKRKEEEQREIKKEIERRKTGKEMLD 237

  Fly   323 QQARAKEQELKNMQEQIKRERQEELAARERIRAQIAADRAEQAQRFNTPDISSTTNSVAATAASN 387
            .:.:.:|:..|.|.|:..||:.|:.||||||:.|||.||||:|.||     :.|...|.|..|:.
Human   238 YKRKQEEELTKRMLEERNREKAEDRAARERIKQQIALDRAERAARF-----AKTKEEVEAAKAAA 297

  Fly   388 VITTDASVSSVDET---------RLQIRLPGGIQRTKSFPAGEVLATVRVYVRNEMLAASDVRDF 443
            ::...|.:....|:         |:|.|||.|...|..||:...|...|.:....:  .:...:|
Human   298 LLAKQAEMEVKRESYARERSTVARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQTV--GNTYGNF 360

  Fly   444 TLATSYPRREFQTEDEVKTLNELNLVPNAVVLVLT--KEQVNRVVQSGGSLMTMLGTV------I 500
            :|||.:|||||..||..|.|.:|.|.|:|.|::|.  :...:.|..|.|.:.|:||||      |
Human   361 SLATMFPRREFTKEDYKKKLLDLELAPSASVVLLPAGRPTASIVHSSSGDIWTLLGTVLYPFLAI 425

  Fly   501 WALLTPAAKAFDYINKMGLRPLTQKLSVFMANFRWPGQRAGLEVYQGDAAARRNMDMFSLRPTPA 565
            |.|:                          :||                       :|| .|.|.
Human   426 WRLI--------------------------SNF-----------------------LFS-NPPPT 440

  Fly   566 PGYEYDGASTEQTGGSAERPTPQNQPGPGNTPPAHNTSQASASQSQQ--------FQQRPGGYQP 622
                       ||   :.|.|....|.|           ||:|:|::        .::|...:: 
Human   441 -----------QT---SVRVTSSEPPNP-----------ASSSKSEKREPVRKRVLEKRGDDFK- 479

  Fly   623 PKYGDSNIRRLQDTKKDEKDKDKATYNGNSTQQ 655
             |.|.....|.||..:||.:    |:|||||||
Human   480 -KEGKIYRLRTQDDGEDENN----TWNGNSTQQ 507

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8042NP_648165.1 PRK10263 <165..>369 CDD:236669 56/206 (27%)
TPH <269..>367 CDD:464007 38/100 (38%)
Ubl1_cv_Nsp3_N-like 399..476 CDD:475130 30/85 (35%)
UBXN4NP_055422.1 Interaction with UBQLN1. /evidence=ECO:0000269|PubMed:19822669 1..200 80/286 (28%)
Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold 4..109 CDD:469754 44/106 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 117..196 30/158 (19%)
UBX_UBXN4 319..395 CDD:340534 29/77 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 440..508 26/99 (26%)

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