Protein Alignment exex and NKX1-2

DIOPT Version :10

• Sequence 1: NP_648164.1
• Gene: exex / 38884
• FlyBaseID: FBgn0041156
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_001139812.1
• Gene: NKX1-2 / 390010
• HGNCID: 31652
• Length: 310
• Species: Homo sapiens
• Alignment Length: 248
• Identity: 71/248 - (28%)
• Similarity: 102/248 - (41%)
• Gaps: 54/248 - (21%)

  Fly   264 TASNAAAAAQAAASAAGGISEQEALQRIRDSREYDSPSPDGMSRSESPTSSHRSSPPISP--GCE 326
            |.:...|...|...|...::|.||.:        |:.|.|.:.:.|:|.::...:...||  |.|
Human    32 TRAALPAVRPAPREARKSLAEVEAGK--------DASSRDPVRQLETPDAAGPGAGQASPLEGSE 88

  Fly   327 DQQQPHGALHPQHLSMRMSDFHDEFKKPIP--PHSPIRPQDFPLYAGGHPYQLLAQGGSAFHRPL 389
            .::: ..|..|:...:|     :...:.:|  ..||..|..  ..|.|.|.:   .||....|
Human    89 AEEE-EDAEDPRRPRLR-----ERAARLLPGLARSPDAPAG--ALASGEPCE---DGGGGPVR-- 140

  Fly   390 DPSGKP-IPIPMGHNFMPSQLQFEFLARAGMLHHRIPELAAYPHHAILGKTRRPRTAFTSQQLLE 453
            .|.|.| .|.|......|:                            ..|.||.|||||.:||:.
Human   141 SPPGSPGSPRPRRRRLEPN----------------------------CAKPRRARTAFTYEQLVA 177

  Fly   454 LEKQFKQNKYLSRPKRFEVASGLMLSETQVKIWFQNRRMKWKRSKKAQQEAKE 506
            ||.:|:..:|||..:|..:|..|.|:||||||||||||.|||:.......|.:
Human   178 LENKFRATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGADGAAQ 230

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
exex	NP_648164.1	Homeodomain	440..496	CDD:459649	33/55 (60%)
NKX1-2	NP_001139812.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..165		35/177 (20%)
		Homeodomain	164..220	CDD:459649	33/55 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	217..260		4/14 (29%)