Protein Alignment exex and HOXC12

DIOPT Version :10

• Sequence 1: NP_648164.1
• Gene: exex / 38884
• FlyBaseID: FBgn0041156
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_776272.1
• Gene: HOXC12 / 3228
• HGNCID: 5124
• Length: 282
• Species: Homo sapiens
• Alignment Length: 331
• Identity: 83/331 - (25%)
• Similarity: 118/331 - (35%)
• Gaps: 111/331 - (33%)

  Fly   199 HSGATM------ATTTLLP--PAQSQPKKSFCIDALLAKSQHQSGEPQPIIVDDRLAALHYARDQ 255
            |:|.|.      |:...||  |:.|.|::..........::..:|.|||           |....
Human    19 HTGDTFYFPNFRASGAQLPGLPSLSYPRRDNVCSLSWPSAEPCNGYPQP-----------YLGSP 72

  Fly   256 AELNHAFVTASNAAAAAQAAASAAGGISEQEALQRIRDSR-EYDSPSPD----GMSRSESPTSSH 315
            ..||..|                 |...|   |.|:.|.: .|..|..:    |:.|.|     .
Human    73 VSLNPPF-----------------GRTCE---LARVEDGKGYYREPCAEGGGGGLKREE-----R 112

  Fly   316 RSSPPISPGCE-DQQQPHGALHPQHLSMRMSDF------HDEFKKPIPPHSPIRPQDFP------ 367
            ...|...||.. ...:|.|   |..|..:. |:      .|......|||.|...|...
Human   113 GRDPGAGPGAALLPLEPSG---PPALGFKY-DYAAGGGGGDGGGGAGPPHDPPSCQSLESDSSSS 173

  Fly   368 -LYAG------GHPYQLLAQGGSAFHRPLDPSGKPIPIPMGHNFMPSQLQFEFLARAGMLHHRIP 425
             |..|      |.|..|::        ||:|.|.                   |:.:|.
Human   174 LLNEGNKGAGAGDPGSLVS--------PLNPGGG-------------------LSASGA------ 205

  Fly   426 ELAAYPHHAILGKTRRPRTAFTSQQLLELEKQFKQNKYLSRPKRFEVASGLMLSETQVKIWFQNR 490
                 |.:.|..::|:.|..::..||.|||.:|..|::::|.:|.|::..|.||:.|||||||||
Human   206 -----PWYPINSRSRKKRKPYSKLQLAELEGEFLVNEFITRQRRRELSDRLNLSDQQVKIWFQNR 265

  Fly   491 RMKWKR 496
            |||.||
Human   266 RMKKKR 271

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
exex	NP_648164.1	Homeodomain	440..496	CDD:459649	27/55 (49%)
HOXC12	NP_776272.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	94..129		8/39 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	147..214		19/104 (18%)
		Homeodomain	215..271	CDD:459649	27/55 (49%)