DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment exex and HOXA2

DIOPT Version :9

Sequence 1:NP_648164.1 Gene:exex / 38884 FlyBaseID:FBgn0041156 Length:525 Species:Drosophila melanogaster
Sequence 2:NP_006726.1 Gene:HOXA2 / 3199 HGNCID:5103 Length:376 Species:Homo sapiens


Alignment Length:229 Identity:69/229 - (30%)
Similarity:95/229 - (41%) Gaps:57/229 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   317 SSPPI-----SPGCEDQQQPHGALHPQHLSMRMSDFHDEFKKPIPPHSPIRPQDFPLYAGGHPYQ 376
            |.||:     |...:.....|..|.|           ..|::.||..:|          |.||..
Human    24 SFPPVADTFQSSSIKTSTLSHSTLIP-----------PPFEQTIPSLNP----------GSHPRH 67

  Fly   377 LLAQGGSAFHRPLDPSGKPIPI----PMGHNFMPSQLQFEFLARAGMLHHRIPELAA-------- 429
              ..||.....|....|.|:|.    |..:.:|..:       :|......:|..||        
Human    68 --GAGGRPKPSPAGSRGSPVPAGALQPPEYPWMKEK-------KAAKKTALLPAAAAAATAAATG 123

  Fly   430 ---YPHHAIL-------GKTRRPRTAFTSQQLLELEKQFKQNKYLSRPKRFEVASGLMLSETQVK 484
               ..|...|       |.:||.|||:|:.|||||||:|..||||.||:|.|:|:.|.|:|.|||
Human   124 PACLSHKESLEIADGSGGGSRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVK 188

  Fly   485 IWFQNRRMKWKRSKKAQQEAKERAKANQQQQQQQ 518
            :||||||||.||..:.::......|....:..::
Human   189 VWFQNRRMKHKRQTQCKENQNSEGKCKSLEDSEK 222

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
exexNP_648164.1 Homeobox 442..495 CDD:278475 35/52 (67%)
HOXA2NP_006726.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 42..93 16/73 (22%)
Antp-type hexapeptide 94..99 0/4 (0%)
Homeobox 147..200 CDD:395001 35/52 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 198..229 3/25 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 257..279
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0489
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000007
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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