DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment exex and MNX1

DIOPT Version :9

Sequence 1:	NP_648164.1	Gene:	exex / 38884	FlyBaseID:	FBgn0041156	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_005506.3	Gene:	MNX1 / 3110	HGNCID:	4979	Length:	401	Species:	Homo sapiens

Alignment Length:	384	Identity:	130/384 - (33%)
Similarity:	163/384 - (42%)	Gaps:	120/384 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 RLPLMLPANPPGVPSGAAAPPPVSPQPAA------NHLSHSGATMATTTLLPPAQSQPKKSFCID 224
            |:..:|..:||...|..:||..:....||      ......||:..|:....||.|:|..: ..|
Human     8 RIDALLAVDPPRAASAQSAPLALVTSLAAAASGTGGGGGGGGASGGTSGSCSPASSEPPAA-PAD 71

  Fly   225 ALLAKSQHQSGEPQPIIVDDRLAALHYA-------------------RDQAELNHAFVTASNAAA 270
            .|.|:|      |.|    .||.|.|.|                   ......:||...|:.|||
Human    72 RLRAES------PSP----PRLLAAHCALLPKPGFLGAGGGGGGTGGGHGGPHHHAHPGAAAAAA 126

  Fly   271 AAQAAASAAG--------------GISEQEALQRIRDSREYDSPSPDGMSRSESPTSSHRSSPPI 321
            ||.|||:|.|              |:..|.||        |..| ..|.|.:.:.
Human   127 AAAAAAAAGGLALGLHPGGAQGGAGLPAQAAL--------YGHP-VYGYSAAAAA---------- 172

  Fly   322 SPGCEDQQQPHGALHPQHLSMRMSDFHDEFKKPIPPHSPIRPQDFPLYAGGHPYQLLAQGGSAFH 386
                       .||..||                    |.....:|...|.||           .
Human   173 -----------AALAGQH--------------------PALSYSYPQVQGAHP-----------A 195

  Fly   387 RPLDPSGKPIPIPMGHNFMPSQL-QFEFLARAGMLHHRIPELAAYPHHAILGKTRRPRTAFTSQQ 450
            .|.|      ||.:|....  || |:...:.|||:..::|:..:.....:|||.|||||||||||
Human   196 HPAD------PIKLGAGTF--QLDQWLRASTAGMILPKMPDFNSQAQSNLLGKCRRPRTAFTSQQ 252

  Fly   451 LLELEKQFKQNKYLSRPKRFEVASGLMLSETQVKIWFQNRRMKWKRSKKAQQEAKERAK 509
            |||||.|||.|||||||||||||:.|||:|||||||||||||||||||||:::|.:.|:
Human   253 LLELEHQFKLNKYLSRPKRFEVATSLMLTETQVKIWFQNRRMKWKRSKKAKEQAAQEAE 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
exex	NP_648164.1	Homeobox	442..495	CDD:278475	47/52 (90%)
MNX1	NP_005506.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	37..78		11/47 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..120		2/18 (11%)
		Homeobox	244..297	CDD:278475	47/52 (90%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	299..401		6/13 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	109	1.000	Domainoid score	I6393
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4572
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	1	1.000	-	-		oto91678
orthoMCL	1	0.900	-	-		OOG6_107775
Panther	1	1.100	-	-	LDO	PTHR24335
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5619
SonicParanoid	1	1.000	-	-		X3748
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.850