DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment exex and hoxb3a

DIOPT Version :9

Sequence 1:	NP_648164.1	Gene:	exex / 38884	FlyBaseID:	FBgn0041156	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_571192.2	Gene:	hoxb3a / 30339	ZFINID:	ZDB-GENE-990415-104	Length:	417	Species:	Danio rerio

Alignment Length:	332	Identity:	78/332 - (23%)
Similarity:	117/332 - (35%)	Gaps:	136/332 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 SPQPAANHLSH-------SGATMATTTLLPPAQSQPKKS-----FCIDALLAKSQH---QSGEPQ 238
            :|.||..:.:|       |..::.:.....|.|.|..|:     .|:...|....|   |...||
Zfish    28 APAPAFQNSAHLEGDYQRSACSLQSLGTSAPPQPQHAKTKELNGSCMRPSLPPEHHPPPQVSPPQ 92

  Fly   239 PIIVDDRLAALHYARDQAELNHAFVTASNAAAAAQAAASAAGGISEQEALQRIRDSREYDSPSPD 303
                                |...|.|:|  |..|...|..||::                 ...
Zfish    93 --------------------NTVNVAATN--ATQQPGGSGGGGVA-----------------GSG 118

  Fly   304 GMSRSESPTSSHRSSPPIS----PGCEDQQQPHGALHPQHLSMRMSDFHDEFKKPIPPHSPIRPQ 364
            |.|:|.|.:||..::|.::    |..::.:|                 :.:.|...|..|....:
Zfish   119 GTSKSSSKSSSMATNPTLTKQIFPWMKESRQ-----------------NTKQKNSSPSASSANAE 166

  Fly   365 DFPLYAGGHPYQLLAQGGSAFHRPLDPSGKPIPIPMGHNFMPSQLQFEFLARAGMLHHRIPELAA 429
                          :.||..     .|.|.
Zfish   167 --------------SSGGEK-----SPPGS----------------------------------- 177

  Fly   430 YPHHAILGKTRRPRTAFTSQQLLELEKQFKQNKYLSRPKRFEVASGLMLSETQVKIWFQNRRMKW 494
                   ..::|.|||:||.||:||||:|..|:||.||:|.|:|:.|.|||.|:||||||||||:
Zfish   178 -------AASKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLSERQIKIWFQNRRMKY 235

  Fly   495 KRSKKAQ 501
            |:.:|::
Zfish   236 KKDQKSK 242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
exex	NP_648164.1	Homeobox	442..495	CDD:278475	35/52 (67%)
hoxb3a	NP_571192.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..135		25/122 (20%)
		Antp-type hexapeptide	140..145		1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..184		9/114 (8%)
		Homeobox	184..236	CDD:278475	35/51 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	237..290		1/6 (17%)
		DUF4074	353..415	CDD:290032
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..417
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810