Protein Alignment exex and GBX2

DIOPT Version :10

• Sequence 1: NP_648164.1
• Gene: exex / 38884
• FlyBaseID: FBgn0041156
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_001476.2
• Gene: GBX2 / 2637
• HGNCID: 4186
• Length: 348
• Species: Homo sapiens
• Alignment Length: 451
• Identity: 123/451 - (27%)
• Similarity: 155/451 - (34%)
• Gaps: 146/451 - (32%)

  Fly   113 SSQMP--LLVAPMPVGTGPPHS------HPPPPHPRLYV-EGFPPPHHVPHPHPALGTYPLPRLP 168
            |:..|  |::...|:|:....|      .||.|.|..:| .|:|              ..:|..|
Human     2 SAAFPPSLMMMQRPLGSSTAFSIDSLIGSPPQPSPGHFVYTGYP--------------MFMPYRP 52

  Fly   169 LMLPANPPGVPSGAAAPPPVSPQPAANHLSHSGATMATTTLLPPAQ------SQPKKSFCIDALL 227
            ::||..||        |||..||.|..            ..||||.      |.| ..||
Human    53 VVLPPPPP--------PPPALPQAALQ------------PALPPAHPHHQIPSLP-TGFC----- 91

  Fly   228 AKSQHQSGEPQPIIVDDRLAALHYARDQAELNHAFVTASNAAAAAQAAAS---AAGGISEQEALQ 289
                  |...|.:.:...|.|.......|...|     ..||||.:.|..   ..|...:.||||
Human    92 ------SSLAQGMALTSTLMATLPGGFSASPQH-----QEAAAARKFAPQPLPGGGNFDKAEALQ 145

  Fly   290 RIRDSREYDSPSPDGMSRSESPTSSHRSSPPISPGCEDQQQPHGALHPQHLSMRMSDFHDEFKKP 354
            .       |:....|....|....:..::..:      |....||:..|.        .||.|..
Human   146 A-------DAEDGKGFLAKEGSLLAFSAAETV------QASLVGAVRGQG--------KDESKVE 189

  Fly   355 IPPHSPIRPQDFPL-----YAGGHPYQLLAQGGSAFHRPLDPSGKPIPIPMGHNFMPSQLQFEFL 414
            ..|..  :.:.|.|     |:......     |.|.|:..||         ||
Human   190 DDPKG--KEESFSLESDVDYSSDDNLT-----GQAAHKEEDP---------GH------------ 226

  Fly   415 ARAGMLHHRIPELAAYPHHAILGKTRRPRTAFTSQQLLELEKQFKQNKYLSRPKRFEVASGLMLS 479
                .|....|...|.......||.||.||||||:|||||||:|...||||..:|.::|..|.||
Human   227 ----ALEETPPSSGAAGSTTSTGKNRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLS 287

  Fly   480 ETQVKIWFQNRRMKWKRSKKAQQEAK-------------------ERAKANQQQQQQQQTP 521
            |.||||||||||.||||.|.....:|                   ..|..:|.||.:|..|
Human   288 EVQVKIWFQNRRAKWKRVKAGNANSKTGEPSRNPKIVVPIPVHVSRFAIRSQHQQLEQARP 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
exex	NP_648164.1	Homeodomain	440..496	CDD:459649	38/55 (69%)
GBX2	NP_001476.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	59..81		12/41 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	111..139		8/32 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	179..251		22/111 (20%)
		Homeodomain	248..304	CDD:459649	38/55 (69%)