DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment exex and Hoxd8

DIOPT Version :9

Sequence 1:	NP_648164.1	Gene:	exex / 38884	FlyBaseID:	FBgn0041156	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_032302.2	Gene:	Hoxd8 / 15437	MGIID:	96209	Length:	289	Species:	Mus musculus

Alignment Length:	306	Identity:	88/306 - (28%)
Similarity:	111/306 - (36%)	Gaps:	102/306 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 AAAAAQAAASAAGGISEQEALQRIRDSREYD---SPSPDGMSRS--------------ESPTSSH 315
            |||||.|||:||.|    ||:    :...||   :|...|...:              ..|....
Mouse    16 AAAAAAAAAAAAAG----EAI----NPTYYDCHFAPEVSGRHAAALQLYGNSAAGFPHAHPHPHP 72

  Fly   316 RSSPPISPGC-------EDQQQPH-GALHPQHLSMRMSDFHDEFKKPIPPHSPIRPQDFPLYAGG 372
            ..|||  |||       ..|...| ||..|.....         ..|.|||.|..|...|.
Mouse    73 HPSPP--PGCGGGGGPGPGQDYFHAGAGSPTAAYQ---------AAPPPPHPPPPPPPPPC---- 122

  Fly   373 HPYQLLAQGGSAFHRPLDPSGKPIPIPMGHNFMPSQLQFEFLARAGMLHHRIPELAAYPH----- 432
                    ||.|.|      |:|... .|::.:..|..|.....|        ||..||.
Mouse   123 --------GGIACH------GEPAKF-YGYDNLQRQPIFTTQQEA--------ELVQYPDCKSSS 164

  Fly   433 -------------------------HAILGKTRRPRTAFTSQQLLELEKQFKQNKYLSRPKRFEV 472
                                     .|..|: ||.|..::..|.|||||:|..|.||:|.:|.||
Mouse   165 GNIGEDPDHLNQSSSPSQMFPWMRPQAAPGR-RRGRQTYSRFQTLELEKEFLFNPYLTRKRRIEV 228

  Fly   473 ASGLMLSETQVKIWFQNRRMKWKRSKKAQQEAKERAKANQQQQQQQ 518
            :..|.|:|.||||||||||||||:.....:....|.:|.....:::
Mouse   229 SHTLALTERQVKIWFQNRRMKWKKENNKDKFPASRPEAKDGDPKKE 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
exex	NP_648164.1	Homeobox	442..495	CDD:278475	30/52 (58%)
Hoxd8	NP_032302.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..125		20/85 (24%)
		COG5576	139..272	CDD:227863	45/141 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..184		0/21 (0%)
		Antp-type hexapeptide	183..188		0/4 (0%)
		Homeobox	199..251	CDD:278475	30/51 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..289		2/23 (9%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810