DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment exex and Hoxd3

DIOPT Version :9

Sequence 1:	NP_648164.1	Gene:	exex / 38884	FlyBaseID:	FBgn0041156	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_034598.2	Gene:	Hoxd3 / 15434	MGIID:	96207	Length:	433	Species:	Mus musculus

Alignment Length:	223	Identity:	70/223 - (31%)
Similarity:	98/223 - (43%)	Gaps:	33/223 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 YDSPSPDGMSRSESPTS--SHRSSPPI---------------SPGCEDQQQPHGALHPQHLSMRM 344
            |..|:......|:.|:|  |.:||.|:               .||..:.|...|...|..|:...
Mouse    50 YPPPAAANSLDSDYPSSACSIQSSAPLRAPAHKGAELNGSCMRPGTGNSQGGGGGNQPPGLNSEQ 114

  Fly   345 SDFHDEFKKPIPPHSPIRPQDFPLYAGGHPYQLLAQGGSAFHRPLDPSGKPIPIPMGHNFMPSQL 409
            ..     .:|.||..|..|...|...|........:||.:.........|.| .|.......:..
Mouse   115 QP-----PQPPPPPPPTLPPSSPTNPGSGVPAKKTKGGLSASSSSSTISKQI-FPWMKESRQNSK 173

  Fly   410 QFEFLARAG-MLHHRIPELAAYPHHAILGKTRRPRTAFTSQQLLELEKQFKQNKYLSRPKRFEVA 473
            |....|.:| ....:.|...|         ::|.|||:||.||:||||:|..|:||.||:|.|:|
Mouse   174 QKNSCATSGENCEDKSPPGPA---------SKRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMA 229

  Fly   474 SGLMLSETQVKIWFQNRRMKWKRSKKAQ 501
            :.|.|:|.|:||||||||||:|:.:||:
Mouse   230 NLLNLTERQIKIWFQNRRMKYKKDQKAK 257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
exex	NP_648164.1	Homeobox	442..495	CDD:278475	34/52 (65%)
Hoxd3	NP_034598.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..198		32/162 (20%)
		Antp-type hexapeptide	161..166		2/5 (40%)
		Homeobox	199..251	CDD:278475	34/51 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..280		70/223 (31%)
		DUF4074	370..431	CDD:290032
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	401..433
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810