DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8111 and TMEM43

DIOPT Version :9

Sequence 1:	NP_648162.2	Gene:	CG8111 / 38881	FlyBaseID:	FBgn0035825	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_077310.1	Gene:	TMEM43 / 79188	HGNCID:	28472	Length:	400	Species:	Homo sapiens

Alignment Length:	382	Identity:	128/382 - (33%)
Similarity:	196/382 - (51%)	Gaps:	56/382 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LSETLRSHWPIALFGVILFVAGGTELYWNEGRAVHNMMALDEAHADIY---SVRFTEEEQEVGLE 65
            ||||...    ...|::.|:.....::.|||||:....:|.|..:.:.   |:.....|.    |
Human    29 LSETSGG----MFVGLMAFLLSFYLIFTNEGRALKTATSLAEGLSLVVSPDSIHSVAPEN----E 85

  Fly    66 GRIVHLSGPILVGEPLTEPDYNIQLLAVKLRRRVQMYQWVEEAVEHNYGDSVGTTHSDSRTYYYT 130
            ||:||:.|.:...:.|::|:|.:.|.||||||.|:||||||......|.:. |....::| |.|.
Human    86 GRLVHIIGALRTSKLLSDPNYGVHLPAVKLRRHVEMYQWVETEESREYTED-GQVKKETR-YSYN 148

  Fly   131 REWRDKIVDSRNFYNRHGHTNPSHFPIESHVQVADAVFIGRYELGAEVKEKFNNYQELTSDIRPE 195
            .|||.:|::|:||....||.|||...:||.:..|..|.|||:.|.:.:.:|.:|::.|:.. :.|
Human   149 TEWRSEIINSKNFDREIGHKNPSAMAVESFMATAPFVQIGRFFLSSGLIDKVDNFKSLSLS-KLE 212

  Fly   196 DSGVKLHLGI------YYHTNDVFNPEVGDLRLLFSFAGMEGE--------VFSVVGKLSGNKLV 246
            |.    |:.|      :||:.:...|||||||:.||:||:.|:        |.:|:.:..|::||
Human   213 DP----HVDIIRRGDFFYHSENPKYPEVGDLRVSFSYAGLSGDDPDLGPAHVVTVIARQRGDQLV 273

  Fly   247 PYITSRGVPVLLVYPGGLSVQEVFRLEARAQVLHTWWWRFVGWLLIFFGVTCNTKILRLLFVRVP 311
            |:.|..|..:||::.|..|.:|||..|.|:..:.||..|..||:.:|.|:...|:||..|.
Human   274 PFSTKSGDTLLLLHHGDFSAEEVFHRELRSNSMKTWGLRAAGWMAMFMGLNLMTRILYTLV---- 334

  Fly   312 LLVALAPDPQFPVTGNLL----------IAFSLALTIAAVAWILHRPVIGACLLLAG 358
                    ..|||..:|:          :|.||.|...|..|:.:||:  ..||:||
Human   335 --------DWFPVFRDLVNIGLKAFAFCVATSLTLLTVAAGWLFYRPL--WALLIAG 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8111	NP_648162.2	DUF1625	102..348	CDD:285081	89/269 (33%)
TMEM43	NP_077310.1	TMEM43	122..373	CDD:311639	89/269 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155201
Domainoid	1	1.000	144	1.000	Domainoid score	I4619
eggNOG	1	0.900	-	-		E1_28KAC
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11532
Inparanoid	1	1.050	187	1.000	Inparanoid score	I3935
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58749
OrthoDB	1	1.010	-	-		D548440at33208
OrthoFinder	1	1.000	-	-		FOG0008375
OrthoInspector	1	1.000	-	-		oto88585
orthoMCL	1	0.900	-	-		OOG6_105556
Panther	1	1.100	-	-	LDO	PTHR13416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4789
SonicParanoid	1	1.000	-	-		X6362
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.800