DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KRT82 and krt9.1

DIOPT Version :9

Sequence 1:	NP_149022.3	Gene:	KRT82 / 3888	HGNCID:	6459	Length:	513	Species:	Homo sapiens
Sequence 2:	XP_002939076.3	Gene:	krt9.1 / 100490729	XenbaseID:	XB-GENE-22060992	Length:	491	Species:	Xenopus tropicalis

Alignment Length:	477	Identity:	123/477 - (25%)
Similarity:	218/477 - (45%)	Gaps:	56/477 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    28 VTHYAVS--KGPCRPGGGRGLRALGCLGSRS--LC---NVGFGRPRVASRCGGTLPGFGYRLGA- 84
            |.:||.|  .|....||..|.|.:|..|:.:  :|   .||||....:...||...|.||..||
Frog    41 VVNYAGSLRSGYGGHGGHGGSRGVGFSGASAGGVCFDSGVGFGHGGESGFGGGAGYGGGYGFGAG 105

Human    85 --TCG----------PSACITPVTINESLLVPLALEIDPTVQRVKRDEKEQIKCLNNRFASFINK 137
              ..|          |..    :::||.:          |:|.           ||:|.|:::||
Frog   106 YMAAGGGHRSGFGEEPGL----LSLNEKI----------TMQN-----------LNDRLATYLNK 145

Human   138 VRFLEQKNKLLETK---WNFMQQQRCCQTNIEPIFEGYISALRRQLDCVSGDRVRLESELCSLQA 199
            |:.||:.|..||.|   |.........|......|...|..|::::...:.|..|:..::.:.:.
Frog   146 VKSLEEANTDLEKKIRNWYDTHGPSPVQEKDYGPFYRTIEDLQKKILGATIDNGRIVLQIDNAKL 210

Human   200 ALEGYKKKYEEELSLRPCVENEFVALKKDVDTAFLMKADLETNAEALVQEIDFLKSLYEEEICLL 264
            |.:.::.|||.||.||..||::...||:.:|...|.::|||:..|.|.:|:..||..:|||:..|
Frog   211 AADDFRMKYENELILRQTVESDINGLKRLLDDLTLNRSDLESQLENLKEELAGLKKNHEEEMKAL 275

Human   265 QSQISETSVIVKMDNSRELDVDGIIAEIKAQYDDIASRSKAEAEAWYQCRYEELRVTAGNHCDNL 329
            :.|: ...|.|.|..:..:|:..::.:::..|:.|..:::.:.|.|||.:..|||.........:
Frog   276 KVQL-VGDVTVDMKAAPGIDLQKVLGDLRHDYEQIMQKNQKDIEFWYQEKTAELRKNVSGSTQEI 339

Human   330 RNRKNEILEMNKLIQRLQQETENVKAQRCKLEGAIAEAEQQGEAALNDAKCKLAGLEEALQKAKQ 394
            :....::.|:.:.:|.|:.:.:...:.:..||.::||.|.:....|:..:..:..:|..|...:.
Frog   340 QTTNTQVTELRRTLQNLEIDLQAQLSTKAALEASLAETEGRYCLQLSQLQALIQNVEAELANIRC 404

Human   395 DMACLLKEYQEVMNSKLGLDIEIATYRRLLEGEEHRLCEGIGPVNISVSSSKGAFLYEPCGVSTP 459
            :|.....||:.:::.|..|:.||.|||.||:|:..:..:|....:.|..|..     :..|.|:.
Frog   405 EMENQSHEYKILLDIKTRLEQEINTYRNLLDGQGTQFPKGSYDSSFSSGSQS-----DKQGGSSY 464

Human   460 VLSTGVLRSNGGCSIVGTGELY 481
            .:.|.|  .:|...:|.:.:.|
Frog   465 YVRTRV--EDGDGKVVSSRDQY 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KRT82	NP_149022.3	Head	1..120		29/111 (26%)
		Keratin_2_head	<61..116	CDD:292825	16/67 (24%)
		Filament	120..430	CDD:278467	84/312 (27%)
		Coil 1A	121..155		14/36 (39%)
		Linker 1	156..165		1/8 (13%)
		Coil 1B	166..266		31/99 (31%)
		Linker 12	267..283		4/15 (27%)
		Coil 2	284..427		33/142 (23%)
		Seryl_tRNA_N	327..396	CDD:299883	11/68 (16%)
		Tail	428..513		10/54 (19%)
krt9.1	XP_002939076.3	Filament	127..437	CDD:365827	87/331 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910