DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pbl and mus101

DIOPT Version :9

Sequence 1:	NP_523965.2	Gene:	pbl / 38879	FlyBaseID:	FBgn0003041	Length:	1311	Species:	Drosophila melanogaster
Sequence 2:	NP_524909.1	Gene:	mus101 / 48309	FlyBaseID:	FBgn0002878	Length:	1425	Species:	Drosophila melanogaster

Alignment Length:	1512	Identity:	294/1512 - (19%)
Similarity:	468/1512 - (30%)	Gaps:	538/1512 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 MSIT-TLPTRICLV---------GGVGQDADTLQAAE--------------------SFGLPIVT 48
            |||: ::...||..         ||| |:|||||..|                    |.|.|::.
  Fly     1 MSISMSMDETICAYFVNNLKPGDGGV-QEADTLQQFEAARELLGQQLAETQIRQIKPSEGYPLIA 64

  Fly    49 SD--TGLDILGESSDWRTFYVLDDFEGASFEAIHKQKECILGPPALKYAAEMKQTLGQNSRPIYN 111
            :.  |..|:          :||..|||..||.:.:.:..|||||.|.......:.:.:.|..||:
  Fly    65 AGNLTKKDV----------FVLTQFEGEFFEQLQQTRALILGPPCLITCLRRNEPIPEGSSAIYS 119

  Fly   112 YAMRGVVTCFTGI--RKKDELTKLVNLIHSMGGCIKKDLNTKTTHLICNHSGGEKYQYAKTFRLT 174
            .|||.:....|||  :||:||::|:|.   |||...:....:|||||.|.....||:.|....:.
  Fly   120 TAMRDLQVSATGITPQKKEELSRLINW---MGGIYFQSFGHRTTHLISNTIKSSKYEQATLNGVP 181

  Fly   175 VVRPAWVFAAW--ADRNSLE-FDATQENFTKTHRLKAFEGQKICFFGFPVEEHQHMVDVLLENGG 236
            |:...||...|  :.|:..| ..||..:|.| :||..|.|..|...|..|.....::.::.:|||
  Fly   182 VMHVDWVQYVWDQSRRSQREGIMATDPDFDK-YRLPIFFGANITCSGLDVARKDQVMRLVNDNGG 245

  Fly   237 VCAELDDPECSHVVMPNTGAVFTSTSTSTDTNPSTLINPPESQVPGSSSASQAGEEEQRKAEHLE 301
            :.......:...:|:        :..|.|||
  Fly   246 IYHRAFRSQVVDIVI--------TEQTKTDT---------------------------------- 268

  Fly   302 QAEIKKMEYSHAETDNGMSLDIDQEQKENQGIEDEDDIHFDERLFVEAADIINHGEDQLPESDEE 366
                                     :|....|..:.|:...|.:|    |..|.|. .||
  Fly   269 -------------------------EKYKAAIRYKKDVLLPEWIF----DSCNRGY-ALP----- 298

  Fly   367 DLEEEQKPKVEEVLKEQEVEEDVQASTPKTSKIRTSLKAATPLSSPEMDGIAL------DFESTT 425
                         .|:.||.....:|||        .|...|.::|..|...|      .|.|.:
  Fly   299 -------------TKDYEVRPGKTSSTP--------TKTTRPGAAPGADQTHLSDLSRISFVSGS 342

  Fly   426 QNISPILKAIDECDLETDDLPPSENDLK---------------------RKRESFDNVSLMSVDS 469
            :.:...|..::|.........|::..||                     :|..:|.:...:.:..
  Fly   343 RRMCSDLSTVNESVSSVGSSSPAKQLLKQATSSGRNYQQVLAEIEPRQAKKAGAFLDGCCVYLSG 407

  Fly   470 FALPASTKKPKLIRTGSISR---------------------------TLRRSVSFV-AEPLMKTL 506
            |......|..:::.||..:|                           .|..||..| .:.|::::
  Fly   408 FRSEEREKLNRVLNTGGATRYDEANEGISHIIVGQLDDAEYRQWQRDGLMGSVHVVRLDWLLESI 472

  Fly   507 RPRR--SSVADASSFVGSEAADNSICSLASSINL-TLNDSIRK---PVKEKLRSFCGRITRSSSR 565
            |..|  |.:....|...:...|  :.|.||...| ::|.|.::   |:|:||  |.........:
  Fly   473 RAGRVVSELVHRVSMPQNREPD--VASPASKRTLRSMNHSFKQPTLPIKKKL--FDQEPDPVQEQ 533

  Fly   566 RHDRGVDGTPECTTL----LDSGFKTPKAPKLRSTATPKTAKRLFGPVSGVVSALTLTNPSTPTP 626
            .|:.     |:.|.|    .|.|......|...|...|..:....    .:...:::.||..|..
  Fly   534 EHEE-----PDHTLLDQYSQDQGAVAQLPPADVSLLQPAASSTQM----DIRQRVSVANPKPPAE 589

  Fly   627 NPNPNTNCTATLDVNDTSIHTFA---------------------FCAAAVTPAMPPSSSSSSSSP 670
            .........:||.::...:..||                     .|.||....:|.|.|......
  Fly   590 GLQLPDLSASTLSIDFDKLDYFAGVSVYVHRECFNEEFFNQMLTECEAAQGLLVPSSFSDEVDFA 654

  Fly   671 ILSTSIAVHSSVQVIKSPE-------ESTTRRNSPAPIE------------EP---MAMVVD--- 710
            |:|..:|.......:|:..       ||..::|...|||            :|   |.:||.
  Fly   655 IVSFEVAFDVKQLPVKARHVVTELFLESCMKKNQLLPIEYYHKHVPATALRQPLKGMTIVVSIYA 719

  Fly   711 ------------------EHTTLTKPEP----------------KNNHTHILKSDWFWYTIQNGY 741
                              ..|.:.|.:|                |.|:. ::.|||.....:.|.
  Fly   720 GLERDFINATAELLGASVNKTFIKKEKPLLVCPSAEGSKYEGAIKWNYP-VVTSDWLVQCARTGQ 783

  Fly   742 ANE-MDYLFGDYLDSITNTPNTDRRDSLPISFNKRKRKRFSQRI----------QLEGTPLGS-- 793
            ... :.||.|...:....:|..  |||     |.|..:|.::..          :.|..|.||
  Fly   784 KLPFVGYLVGKSPEDFPISPRL--RDS-----NSRTARRPNESTLVAQPDVTMEEAENQPAGSVT 841

  Fly   794 ----------------GKRRSSVS----DAGLLSVSNSLFDCTTSPDKLESDKLLHAEPEASDAT 838
                            .||.|.::    .:.|...|||    |:|||              |..|
  Fly   842 PVTAGSPGAPELTPLRNKRVSELAGIPGGSALHRGSNS----TSSPD--------------SPCT 888

  Fly   839 PAKKSMRFNHFMDFYTTESNYVGILDTI--LNLFKNKLEELAETNDPLLNKSEIKTI-------- 893
            |..:.....:.:||.   ..:|..|||.  .:..:..:.|:.|...|.|.:...:..
  Fly   889 PLSQVGAQQYNLDFL---EQFVQRLDTEEGKDCVREIIREMRENQTPELERIRRQACTPVSRKHQ 950

  Fly   894 -----FGNFLPIHEVHQSMLEHLRKLHANWR-------------------------------EDC 922
                 ..:|....|..|.|.:...:   .||                               |:.
  Fly   951 RPAPGIPDFCLTPEFQQRMADDFER---RWRLPTMKIKPDTPLAVIRQRVMRITCETLGIEYEES 1012

  Fly   923 LIGDIIIQHRDELIKAYPP-------YVNFFEQMKEQLQYCDREYPRFHAFLKINQTKPECGRQG 980
            ......:......:|..||       .:||....|.......::.|     |:::...|   |.|
  Fly  1013 NAKTPTLSESPSTVKKKPPTRTTQATKLNFDRSPKTPKLSLGKKTP-----LRVSMGSP---RSG 1069

  Fly   981 LQDLMI----RPVQRLP---SISLLLNDILKHTTSGNADHGRLEEA------------LKAIKQV 1026
            .|...:    .|::..|   |....|::..:.|.  |.|....||:            ...:||:
  Fly  1070 TQSPFVPNTQSPIEAAPPRRSDGPTLSEEGQSTI--NFDKISFEESAVPVLAPDVPTVAPDVKQI 1132

  Fly  1027 TLHINEDKRRTESRMAIFDIFNDIEGC----------------------------PAHLVSSNR- 1062
            |.::...:.|..|.....|  ||:: |                            ||...::.|
  Fly  1133 TDYLKNCESRRNSLKRSHD--NDMD-CGESEVQYVQPFESEGFALGTEDMVDWRDPAEFNAAKRR 1194

  Fly  1063 --------------SFILKC--------EVNELSDSLSGR-GDSLVLYLFSDSIELCKRRSKGFN 1104
                          .|.:.|        |:......|.|: .::||.|..|.:..||:|.::|
  Fly  1195 SSGGSPKMQYAGIPCFSISCGDDDEKRAELIARITQLGGKVCENLVNYDDSCTHLLCERPNRG-- 1257

  Fly  1105 TAKSPSTAKTHKHLKLISLNTIRLVIDISDSPRAFGLLLRGD--KEKLYTF---------TISDE 1158
                      .|.|..|:.....|.|...:...|     |||  .|.||.:         |::.|
  Fly  1258 ----------EKMLACIAAGKWILNIQYIEQSHA-----RGDFLDETLYEWGNPKAINLPTLAPE 1307

  Fly  1159 ETDKSVYVKKLCNQIAA 1175
            |...:..|.:...:::|
  Fly  1308 EEPIAAAVHRWRTELSA 1324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pbl	NP_523965.2	PTCB-BRCT	117..180	CDD:289507	22/64 (34%)
		RhoGEF	852..1032	CDD:279015	40/251 (16%)
		PH_Ect2	1023..1186	CDD:269936	42/216 (19%)
mus101	NP_524909.1	BRCT	118..188	CDD:278934	26/72 (36%)
		BRCT	216..290	CDD:278934	18/144 (13%)
		BRCT	397..472	CDD:278934	11/74 (15%)
		BRCT	707..778	CDD:278934	12/71 (17%)
		BRCT	1210..1279	CDD:237994	18/80 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D305707at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47399
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010