Protein Alignment pbl and topbp1

DIOPT Version :9

• Sequence 1: NP_523965.2
• Gene: pbl / 38879
• FlyBaseID: FBgn0003041
• Length: 1311
• Species: Drosophila melanogaster
• Sequence 2: NP_001186667.1
• Gene: topbp1 / 407679
• ZFINID: ZDB-GENE-060626-1
• Length: 1526
• Species: Danio rerio
• Alignment Length: 1440
• Identity: 272/1440 - (18%)
• Similarity: 469/1440 - (32%)
• Gaps: 442/1440 - (30%)

  Fly    30 GQDAD-TLQA--------AESFGLPIVTSDTGLDILGESSDWRTFYVLDDFEGASFEAIHKQKEC 85
            ||.:| .|||        :|.: :.:|..:..|::  :.:| ::.:|..||..::|:...:....
Zfish    18 GQKSDVALQAYKAIVELQSEKY-VQMVDEEAALEL--DHND-KSLFVFSDFTSSAFDHCRRLGCR 78

  Fly    86 ILGPPALKYAAEMKQTLGQNSRPIYNYAMRGVVTCFTGIRKKDELTKLVNLIHSMGGCIKKDLNT 150
            |:.|..:.:..:.::.:.:..:|:||.:|..|....|.: .|:..:::::||..|||.:.:|||.
Zfish    79 IVSPLVVLFCLQKQRCVPKAEQPVYNMSMADVTVSCTNL-DKEARSEVMDLIQLMGGRVYRDLNV 142

  Fly   151 KTTHLICNHSGGEKYQYAKTFRLTVVRPAWVFAAWADRNSLEFDATQENFTKTHRLKAFEGQKIC 215
            ..|||:....|.:||..|.:....::.|:||.|.|.......|..::.| |:.:|....:|..:|
Zfish   143 SVTHLVAGEVGSKKYLVAASLGKPILLPSWVKACWEKSQDSVFHHSELN-TEDYRCPVLKGCTVC 206

  Fly   216 FFGFPVEEHQHMVDVLLENGGV-CAELDDPECSHVVMPN-TG----------------------- 255
            ..|....|.:.:..:..:||.. ..:|...||:|:::.. ||
Zfish   207 VTGLSTVERKEVQRLCDQNGATYTGQLKMNECTHLIVNEPTGQKYEFARKWNVYCVSLHWLFDSI 271

  Fly   256 -----------AVFTSTSTSTDTNPSTLINPPESQVPGSSSASQAGEEEQRKAEHLEQAEIKKME 309
                       ||.......||.....    |.:..|...|.|:..........|:
Zfish   272 EKGFCQDESRYAVERGDKRKTDDKSGR----PNTSTPTGQSRSKEDGPSLLGLSHI--------- 323

  Fly   310 YSHAETDNGMSLDIDQEQKENQGIEDEDDIHFDERLFVEAADIINHGEDQLPESDEEDLEEEQKP 374
                   :.:||::::......||.     |.:....|::.||.....|.|.:..:..|
Zfish   324 -------SNISLNVNETALTTAGIS-----HIEMPDPVDSFDITVCRVDDLLDGCKLYL------ 370

  Fly   375 KVEEVLKEQEVEEDVQASTPKTSKIRTSLKAATPLSSPEMDGIALDFESTTQNISPILKAIDECD 439
                          ...|..|..|:|..:..|.          .|.|...||.::.|:  :.|.|
Zfish   371 --------------CGLSGKKLEKLRRMVNTAG----------GLRFNQPTQELTHIV--MGEAD 409

  Fly   440 ------LETDDLPPSENDLKRKRESFDNVSLMSVDSF-------ALPASTKKPKLIRTGSISRTL 491
                  |:.....|....::...|||...||:..:.:       ..||:...|.|.:  :..|..
Zfish   410 QGIKAFLDNATHRPHIVTVQWLLESFSRGSLLPENGYFHPSFLPPAPAAVDIPALHK--AAPRAS 472

  Fly   492 RRSVSFVAEPLMKTLRPRRSSVAD---ASSFVGSEAADNSICSLASSINLTLNDSIRKPV--KEK 551
            |.||:....|     .|.|.|.|:   .|.::|::          .::.|..:.|.|..|  .|.
Zfish   473 RPSVAPPPAP-----SPARQSRAEEDLLSQYMGND----------QTVELPQDTSSRHSVLHPEP 522

  Fly   552 LRSFCGRITRSSSRRHDRGVDGTPECTTLLDS--------------GFKTPKAPKLRSTATPKTA 602
            |                  |:|  :.:||.::              ||......:|.........
Zfish   523 L------------------VEG--KDSTLAEASEGGLFFGKRFILVGFGAEAEAQLSELVMENAG 567

  Fly   603 KRLFGPVSGVVSALTLTNPSTPTPNPNPNTNCTATLDVNDTSIHTF-AFCA--AAVTPAMPPSSS 664
            |.|.|....|.....:           |...|.....|::.:..|: |.|.  ..|.|.
Zfish   568 KILVGRSRAVAHYAIV-----------PLLGCDVEATVDEVATDTWLAMCVEQQCVLPL------ 615

  Fly   665 SSSSSPILSTSIAVHSSVQVIKSPEESTTR-----RNSPAPIEEPMAMVVDEHTTLTKPEPKN-- 722
              :|.| |.|.:||......:|....|.::     |:|...:.:.:...|.::...|..:.|.
Zfish   616 --ASHP-LFTPVAVREGFSPLKDCVLSVSQFTGAERDSLIQLAKHLGASVQDYFVRTANQRKGML 677

  Fly   723 NHTHILKSDWFWYTIQNGYANEMDYLFGDYLDSITNTPNTDRRDSLPISFNKRKRKRFSQRIQLE 787
            ..||:                            :..||...:                .|..|..
Zfish   678 ASTHL----------------------------VLQTPEGTK----------------YQAAQKW 698

  Fly   788 GTP----------LGSGKRRSSVSDAGLLSVSNSLFDCTTSPDKLESDKLLHAEPEASDATPAKK 842
            |.|          ..:|||    :|.|     ..|.|...||::.| |..:.|..:  |..|.:.
Zfish   699 GLPAVTIRWVLESARTGKR----ADEG-----QYLVDLPPSPERTE-DSFVGASQK--DPPPLRL 751

  Fly   843 SMRFNHFMDFYTTESNYVGILDT----------ILNLFKNKLEELAETNDPLLNKSEIKTIFGNF 897
            ..|...........|:.:..|||          .:...|...||.||...|  .:.|.|
Zfish   752 HQRSPELPLLGPQNSDAITPLDTARFQSRSVRSAVRKLKQGEEEQAEVTTP--GQEEAK------ 808

  Fly   898 LPIHEVHQSMLEHLRKLHANWREDCLIGDIIIQHRDELIKAYPPYVNFFEQMKEQLQYCDREYPR 962
                    ...:....||.:.....|..|          |.:.|..|    .|:...:
Zfish   809 --------GAQQKDSSLHLDTPSRFLSRD----------KLFGPSFN----TKDVFDH------- 844

  Fly   963 FHAFLKINQTKPECGRQGLQDLMIRPVQRLPSISLLLNDILKHTTSGNADHGRLEEALKAIKQVT 1027
                |:....|.:.| ||.:..:...::|         ::.....:.|..|.....|:.|..|:.
Zfish   845 ----LQTPGNKSQQG-QGAETPLSEVIER---------NLKAAVANSNRSHVTNLAAMTASPQLG 895

  Fly  1028 LHINEDKRRTESRMAIFDIFNDIEGCPAHLVSSNRSFILKCEVNELSDSLSGR-----GDSLVLY 1087
               .|.:...|.:.|.  ..:.:..|.:..:|..:|     |:|.::.||...     .||:..|
Zfish   896 ---KEPEPEVEQKAAA--PLSGVVVCVSKKLSKKQS-----ELNAVAASLGAEFRWSCDDSVTHY 950

  Fly  1088 LFSDSIELCKRRSKGFNTAKSPSTAKTHKHLKLISLNTIRLVID----ISDSPRAFGLLLRGDKE 1148
            ::...:   ...||.:...|       .:.|.::|.:.::...|    :|:|
Zfish   951 IYQGKV---GDNSKEYRAVK-------ERGLYIVSQHWLQACADEQKHVSES------------- 992

  Fly  1149 KLYTFTISDEETDKSVYVKKLCNQIAAHTCR-----TDADKLLICRTSQELEV----DISDVN-- 1202
             ||.||.:.:       :....:|:|..|.|     |...:|.....::|..:    ||:||:
Zfish   993 -LYPFTFNPK-------MSLTMSQMADSTQRSPPSATPRTRLRAFAENEETRLGPDDDITDVSTP 1049

  Fly  1203 -------------VSTLSKAFKLAAKTRLKVGRAFSFNKTPNKL---KRAVSTM-MTSPFGSTNS 1250
                         :||..|......:.|..:.|......:..||   :|..|.: .|.|.|..:.
Zfish  1050 KQGSVGEPEKDQTISTEKKNLTETLEMRESLQRQLQEIMSATKLTSGRRGSSRLAKTGPGGLDSP 1114

  Fly  1251 LTPAS---------QLAQMRLAS--CTNINEV---------DDEDCASMRS---------SSPST 1286
            .||.|         .|..:|::.  |.::|..         ||......|:         .|||.
Zfish  1115 HTPDSLGRMSRRSRNLEAIRMSRQVCVDLNTEPSQSEQIVWDDPTAREERAKLADNLQWPGSPSQ 1179

  Fly  1287 QSEML-VVPP 1295
            .||.| :|||
Zfish  1180 HSEPLALVPP 1189

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pbl	NP_523965.2	PTCB-BRCT	117..180	CDD:289507	19/62 (31%)
		RhoGEF	852..1032	CDD:279015	31/189 (16%)
		PH_Ect2	1023..1186	CDD:269936	31/176 (18%)
topbp1	NP_001186667.1	BRCT	109..178	CDD:237994	22/69 (32%)
		PTCB-BRCT	203..266	CDD:289507	11/62 (18%)
		BRCT	359..435	CDD:278934	18/107 (17%)
		PTCB-BRCT	636..707	CDD:289507	14/114 (12%)
		BRCT	909..982	CDD:278934	15/87 (17%)
		BRCT	1272..1339	CDD:237994
		BRCT	<1418..1479	CDD:214602

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D305707at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920