DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pbl and Ptip

DIOPT Version :9

Sequence 1:	NP_523965.2	Gene:	pbl / 38879	FlyBaseID:	FBgn0003041	Length:	1311	Species:	Drosophila melanogaster
Sequence 2:	NP_729947.2	Gene:	Ptip / 39552	FlyBaseID:	FBgn0052133	Length:	2294	Species:	Drosophila melanogaster

Alignment Length:	399	Identity:	68/399 - (17%)
Similarity:	128/399 - (32%)	Gaps:	122/399 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 IHKQKECILGPPALKYAAEMKQTLGQNSRPIYNYAMRGVVTCFTGIRKKDELTKLVNLIHSMGGC 143
            :|..|   ||        .|..|...:..|.....|||:....|.:...|. .:|..::...|..
  Fly    77 VHSAK---LG--------RMASTRAFDPSPNQMRLMRGIRVAITNVVAGDR-RRLYAMLTYHGAV 129

  Fly   144 IKKDLNTKTTHLICNHSGGEKYQYAKTF---RLTVVRPAWVFAAWADRNSLEFDATQENFTKTHR 205
            :........|||:|..:.|..|..|...   .:.:|.|.||      .:||::
  Fly   130 VTHSFGATNTHLVCGAANGGIYNKALALPKNAIIIVTPDWV------TDSLKY------------ 176

  Fly   206 LKAFEGQKICFFGFPVEEHQHMVDVLLENGGVCAELDDPECSHVVMPNTGAVFTSTSTSTDTNPS 270
                   |.|   .|||                                            |...
  Fly   177 -------KNC---MPVE--------------------------------------------TYHP 187

  Fly   271 TLINPPESQVPGSSSASQAGE-EEQRKAEHLEQAEIKKMEYSHAETDNGMSLDIDQEQKENQGIE 334
            .|:.|.|.|......|:|..: ::|::.:|..|.: ::.:....:..........|:|::.|..:
  Fly   188 RLLKPIEKQRTQKQQATQQQQIQQQQQLQHQHQMQ-QQQQQQQQQQQQQQQQQQQQQQQQQQQQQ 251

  Fly   335 DEDDIHFDERLFVEA------ADIINHGEDQLP-----------ESDEEDLEEEQKP-----KVE 377
            .:...|..:.:..:|      :||:..|||.:.           ::..|.::::|.|     :|.
  Fly   252 QQQQQHQQQIIQQQATATSALSDILGFGEDSVAAKSIASIKSQLQASAEQIQQQQLPVPAQQQVV 316

  Fly   378 EVLKEQEVEEDVQASTPKTSKIRTSLKAATPLSSPEMDG---------IALDFESTTQNISPILK 433
            .|..:.:.::..|.|..:..  :...:|.||...|:...         |..:.:...||...|..
  Fly   317 FVRPQPQPQQPAQQSPHQLQ--QGGPQAPTPAPHPQHQQQLIIQQQKIIPANLQQQPQNQQQIKN 379

  Fly   434 AIDECDLET 442
            .:.:..::|
  Fly   380 ILQQRQMKT 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pbl	NP_523965.2	PTCB-BRCT	117..180	CDD:289507	13/65 (20%)
		RhoGEF	852..1032	CDD:279015
		PH_Ect2	1023..1186	CDD:269936
Ptip	NP_729947.2	BRCT	9..77	CDD:214602	68/399 (17%)
		BRCT	96..174	CDD:278934	18/84 (21%)
		BRCT	1814..1887	CDD:237994
		PTCB-BRCT	1914..1976	CDD:289507
		BRCT	<2087..2142	CDD:237994
		BRCT	2175..2265	CDD:278934
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D305707at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.010