Protein Alignment pbl and Ect2

DIOPT Version :9

• Sequence 1: NP_523965.2
• Gene: pbl / 38879
• FlyBaseID: FBgn0003041
• Length: 1311
• Species: Drosophila melanogaster
• Sequence 2: NP_001102017.2
• Gene: Ect2 / 361921
• RGDID: 1308524
• Length: 913
• Species: Rattus norvegicus
• Alignment Length: 1319
• Identity: 326/1319 - (24%)
• Similarity: 486/1319 - (36%)
• Gaps: 535/1319 - (40%)

  Fly     1 MEMETIEEQSKCE--------MSITTLPTRICLVGGVGQDADTLQAAESFGLPIVTSDTGLDILG 57
            ||:..|:.:..|.        .||..:..::..|        .:.:.|.||        .||
  Rat    75 MEVPVIKIKESCPGKSDEKLIKSIINMEIKVPCV--------KMDSMEEFG--------SLD--- 120

  Fly    58 ESSDWRTFYVLDDFEGASFEAIHKQKECILGPPALKYAAEMKQTLGQNSRPIYNYAMRGVVTCFT 122
             |.::...:|:.||:.:.|..::|....|:|||.:...|:|.:.|..:.||:|..:|..:|.|||
  Rat   121 -SPEFENIFVVTDFQTSVFNDLYKADCRIVGPPVILNCAQMGEPLPFSCRPLYCTSMLNLVLCFT 184

  Fly   123 GIRKKDELTKLVNLIHSMGGCIKKDLNTKTTHLICNHSGGEKYQYAKTFRLTVVRPAWVFAAWAD 187
            |.|||:||.|||.|:|.|||.|:|:.|:|.|||:.|.:.|||::.|.:....::||.|::.||..
  Rat   185 GFRKKEELVKLVTLVHHMGGVIRKECNSKVTHLVANCTQGEKFRVAVSLGTPIMRPGWIYEAWER 249

  Fly   188 RNSLEFDATQENFTKTHRLKAFEGQKICFFGFPVEEHQHMVDVLLENGGVCAELDDPECSHVVMP 252
            ||...|.|..::|....::..|:...:.|.||..||...|.::....||....:.|..|:|:::
  Rat   250 RNEQCFCAADDDFRNEFKVPPFQDCILSFLGFSDEEKHSMEEMTEMQGGTYLPVGDERCTHLIV- 313

  Fly   253 NTGAVFTSTSTSTDTNPSTLINPPESQVPGSSSASQAGEEEQRKAEHLEQAEIKKMEYSHAETDN 317
                                                                             
  Rat   314 ----------------------------------------------------------------- 313

  Fly   318 GMSLDIDQEQKENQGIEDEDDIHFDERLFVEAADIINHGEDQLPESDEEDLEEEQKPKVEEVLKE 382
                                                          ||..::|
  Rat   314 ----------------------------------------------DENTVKE------------ 320

  Fly   383 QEVEEDVQASTPKTSKIRTSLKAATPLSSPEMDGIALDFESTTQNISPILKAIDECDLETDDLPP 447
                                                |.||                        |
  Rat   321 ------------------------------------LPFE------------------------P 325

  Fly   448 SENDLKRKRESFDNVSLMSVDSFALPASTKKPKLIRTGSISRTLRRSVSFVAEPLMKTLRPRRSS 512
            |
  Rat   326 S---------------------------------------------------------------- 326

  Fly   513 VADASSFVGSEAADNSICSLASSINLTLNDSIRKPVKEKLRSFCGRITRSSSRRHDRGVDGTPEC 577
                                                                             
  Rat   327 ----------------------------------------------------------------- 326

  Fly   578 TTLLDSGFKTPKAPKLRSTATPKTAKRLFGPVSGVVSALTLTNPSTPTPNPNPNTNCTATLDVND 642
                                     |:||
  Rat   327 -------------------------KKLF------------------------------------ 330

  Fly   643 TSIHTFAFCAAAVTPAMPPSSSSSSSSPILSTSIAVHSSVQVIKSPEESTTRRNSPAPIEEPMAM 707
                                                                             
  Rat   331 ----------------------------------------------------------------- 330

  Fly   708 VVDEHTTLTKPEPKNNHTHILKSDWFWYTIQNGYANEMDYLFGD--YLDSITNTPNTDRRDSLPI 770
                               ::|.:|||.:||      ||...|:  ||....|||...:..|| :
  Rat   331 -------------------VVKQEWFWGSIQ------MDARAGETMYLYEKANTPELKKSVSL-L 369

  Fly   771 SF----NKRKRKRFSQRI-----QLEGTPLGSGKRRS---SVSDAGLLSVSNSLFDCTTSPDKL- 822
            |.    :.|||:|..:.:     :.:.:|....||.|   |:|...||.:||       :||..
  Rat   370 SLSTPNSNRKRRRLKESLAQLSRETDLSPFPPRKRPSAEHSLSIGSLLDISN-------TPDSSI 427

  Fly   823 ---ESDKLLHAEPEASDATPAKKSMRFNHFMDFYTTESNYVGILDTILNLFKNKLEELAETNDPL 884
               |:.|.......:|...|.|:|.|:....:.|.||||||.||.||:.||:..|||..:...|:
  Rat   428 HYGETPKSCAKSSRSSTPVPPKQSARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPI 492

  Fly   885 LNKSEIKTIFGNFLPIHEVHQSMLEHLRKLHANWREDCLIGDIIIQHRDELIKAYPPYVNFFEQM 949
            |...|||||||:...|.:||..:.:.|..|.|||.|...||||.:::..:|:|.|||:|||||..
  Rat   493 LAPEEIKTIFGSIPDIFDVHMKIKDDLEDLIANWDESRSIGDIFLKYSKDLVKTYPPFVNFFEMS 557

  Fly   950 KEQLQYCDREYPRFHAFLKINQTKPECGRQGLQDLMIRPVQRLPSISLLLNDILKHTTSGNADHG 1014
            ||.:..|:::.|||||||||||.|||||||.|.:|:|||||||||::|||||:.|||...|.|..
  Rat   558 KEMIIKCEKQKPRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKS 622

  Fly  1015 RLEEALKAIKQVTLHINEDKRRTESRMAIFDIFNDIEGCPAHLVSSNRSFILKCEVNELSDSLSG 1079
            .||:|:.::|:|..|||||||:||::..|||:..:::||||:|:||:||.|.:.|...|.:....
  Rat   623 TLEKAIGSLKEVMTHINEDKRKTEAQKQIFDVVYEVDGCPANLLSSHRSLIQRVETVSLGEHPCD 687

  Fly  1080 RGDSLVLYLFSDSIELCKRRSKGFNTAKSPSTAKTH-----KHLKLISLNTIRLVIDI---SDSP 1136
            ||:.:.|:||:|.:|:.::|.|...|.:||.. :|.     ||:.|:.|:.|:.|:||   .|..
  Rat   688 RGEQVTLFLFNDCLEIARKRHKVIGTFRSPHD-RTRPPASLKHIHLMPLSQIKKVLDIRETEDCH 751

  Fly  1137 RAFGLLLRGDKEK---LYTFTISDEETDKSVYVKKLCNQIAAHTCRTDADKLLICRTSQELEVDI 1198
            .||.||:|...|:   |.:|.::.||..|..::|.||..:|...|:.||:.|:.....:..||:.
  Rat   752 NAFALLVRPPTEQANVLLSFQMTSEELPKESWLKMLCRHVANTICKADAENLMYVTDPESFEVNT 816

  Fly  1199 SDVNVSTLSKAFKLAAKTRLKVGRAFSFNKTPNKLKRAVSTMMTSPFGSTNSLTPAS-QLAQMRL 1262
            .|:: ||||:|.:...||..||.|||||:|||   |||:...::|...|.....|:| :||..||
  Rat   817 KDMD-STLSRASRAIKKTSKKVTRAFSFSKTP---KRALRMALSSSHSSEGRSPPSSGKLAVSRL 877

  Fly  1263 ASCTNINEVDDEDCASMRS 1281
            :|.:::..:......|:.|
  Rat   878 SSTSSLAGIPSPSLVSLPS 896

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pbl	NP_523965.2	PTCB-BRCT	117..180	CDD:289507	32/62 (52%)
		RhoGEF	852..1032	CDD:279015	97/179 (54%)
		PH_Ect2	1023..1186	CDD:269936	66/173 (38%)
Ect2	NP_001102017.2	PTCB-BRCT	179..242	CDD:289507	32/62 (52%)
		BRCT	266..341	CDD:278934	27/532 (5%)
		RhoGEF	456..640	CDD:279015	97/183 (53%)
		PH_Ect2	631..804	CDD:269936	66/173 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344449
Domainoid	1	1.000	193	1.000	Domainoid score	I3107
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7298
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D305707at33208
OrthoFinder	1	1.000	-	-		FOG0007255
OrthoInspector	1	1.000	-	-		oto95738
orthoMCL	1	0.900	-	-		OOG6_104055
Panther	1	1.100	-	-	LDO	PTHR16777
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5358
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.850