Protein Alignment pbl and rgf3

DIOPT Version :9

• Sequence 1: NP_523965.2
• Gene: pbl / 38879
• FlyBaseID: FBgn0003041
• Length: 1311
• Species: Drosophila melanogaster
• Sequence 2: NP_588115.1
• Gene: rgf3 / 2539437
• PomBaseID: SPCC645.06c
• Length: 1275
• Species: Schizosaccharomyces pombe
• Alignment Length: 856
• Identity: 176/856 - (20%)
• Similarity: 289/856 - (33%)
• Gaps: 315/856 - (36%)

  Fly   619 TNPSTPTPNPNPNTNCTATLDVNDTSIHTFAFCAAAVTPAMP-------------PSSSSSSSSP 670
            |:|...:|....|     |:|         :|.....||..|             |||.||.|||
pombe   136 TDPFLTSPGNKQN-----TVD---------SFRPLPETPVSPGGSLVHPLPRPPLPSSVSSHSSP 186

  Fly   671 ILSTS----IAVHSSVQVIKSPEE----STTR--RNSPAPI----------EEPMAMVVDEHTTL 715
            ..:||    .::::.:.:..|||.    |.||  ..:|:||          :.|::..|:   .|
pombe   187 YSTTSSTSLYSLYNDISLSCSPEPYLPLSPTRSPARTPSPIRLYSSDALRPQSPLSPSVE---YL 248

  Fly   716 TKPEPKNNHTHILKSD--------------------------------------------WF--- 733
            |.|.|     :.||||                                            |.
pombe   249 TPPNP-----YSLKSDISSTRQLPKIPVQDYASGKISSPLITRTHRRAQSETLFSSCREPWLVGK 308

  Fly   734 ---W-----YTIQNGYANE---------------------MDYL---------FGDYLD-SITNT 759
               |     :|...|..:|                     |::|         .||::: .:...
pombe   309 LYKWCKEEVFTALGGLVHEGVSRREVAQVMATLFTIHIASMEFLIAEIIAKNILGDWINYGLVEV 373

  Fly   760 PNTDRRDSLPISFNKRKRKRFSQRIQLEGTPLGSG---------------KRRSSVSDAGLLS-- 807
            .|.::   |.|:|...:            .|.|||               :.||..|.....|
pombe   374 INLEK---LQIAFTSNE------------PPSGSGVLPFLTNGGCYSYICRSRSCPSKYQCYSCR 423

  Fly   808 -VSNSLFDCTTSPDKLESDKLLHAEPEASDATPAKKS----MRFNHFMDFYTTESNYVGILDTIL 867
             ..||..:.|:.|.:......:.....:.::.|:..|    .|.|:..:....||:||..|:|:.
pombe   424 CARNSSLEFTSLPGQSSDTWSIFWNISSLNSLPSSLSKREIARQNNIHELICKESDYVADLNTLA 488

  Fly   868 NLFKNKLEELAETNDPLLNKSE----IKTIFGNFLPIHEVHQSMLEHLRKLHAN-------WRED 921
            .||:   :.:.:..|.::..:.    |:::|||           :|.:|:||:.       .||.
pombe   489 ELFR---DGIVQQQDAIVPSNRVADFIQSVFGN-----------VESIRQLHSRLFLPQLIMRER 539

  Fly   922 ------CLIGDIIIQHRDELIKAYPPYVNFFEQMKEQLQYCDREY-------PRFHAFLKINQTK 973
                  .:||||:::.   :..|...|:|:    .:|....|..|       ..|..:|...::.
pombe   540 LQGPVVSIIGDILLEW---IHAAKSSYINY----AKQFPLADETYKLECQRNTYFARWLAACRSD 597

  Fly   974 PECGRQGLQDLMIRPVQRLPSISLLLNDILKHTTSGNADHGRLEEALKAIK-------QVTLHIN 1031
            |.|.|...|..:.||.|||...:|.|:.|||||...:.|...:.:|:|.::       .|...:.
pombe   598 PRCRRLDFQHFLQRPTQRLQRYTLELDTILKHTEQSSWDFQLITQAVKELRATCEECDAVIATVL 662

  Fly  1032 EDKRRTESRMAIFDIFNDIEGCPAHLVSSNRSFILKCEVNELSDSLSGRGDSLVLYLF--SDSIE 1094
            |..|..:....:  :|.:.|.....|....|.|..:..|...|||   |.|.|.::||  .:.:.
pombe   663 EANRIRDLSYQL--LFKNHESVNLELRDPEREFFFEGIVQRRSDS---RLDWLDIHLFLLDNYLI 722

  Fly  1095 LCK-RRSKGFNTAK---------------SPS------TAKTHKHLKLI-------SLNT----- 1125
            :.| |:.|..|.::               ||.      .:.|:|.|..:       ||.|
pombe   723 MAKARKDKRTNASRYVVSKRPIPLDLLVLSPKMDDFQLKSNTNKFLGSLAGNLPQESLTTKSKRK 787

  Fly  1126 ----IRLVIDI--------SDSPRAFGLLLRGDKEKLYTFTISDEETDKSVYVKKLCNQIAAHTC 1178
                :.|:.|.        |.:...|      :|.:||.|||               ..:.|:|
pombe   788 SKVNLELMFDATAEKNNENSMNSAVF------EKSQLYPFTI---------------RHLGAYT- 830

  Fly  1179 RTDADKLLICRTSQELEVDISDVNVSTLSKAFKLAAKT--RLKVGRAFSFNKTPNKLKRAVSTMM 1241
               |...|...:.|..::.:..:||:....:.|:..|.  .|||....:|...|:.|...
pombe   831 ---ASYTLYVESLQLRKLWVEKINVAKKRHSQKINIKNPFALKVVSDVAFQYPPSDLVNG----- 887

  Fly  1242 TSPFGSTNSLT 1252
            ..|..|.|.:|
pombe   888 NEPLNSFNEIT 898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pbl	NP_523965.2	PTCB-BRCT	117..180	CDD:289507
		RhoGEF	852..1032	CDD:279015	51/210 (24%)
		PH_Ect2	1023..1186	CDD:269936	42/217 (19%)
rgf3	NP_588115.1	RhoGEF	470..656	CDD:279015	50/206 (24%)
		PH-like	695..850	CDD:302622	36/182 (20%)
		CNH	939..1236	CDD:279162

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	62	1.000	Domainoid score	I2953
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47399
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910