DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pbl and Topbp1

DIOPT Version :9

Sequence 1:NP_523965.2 Gene:pbl / 38879 FlyBaseID:FBgn0003041 Length:1311 Species:Drosophila melanogaster
Sequence 2:XP_006511769.3 Gene:Topbp1 / 235559 MGIID:1920018 Length:1541 Species:Mus musculus


Alignment Length:1259 Identity:236/1259 - (18%)
Similarity:394/1259 - (31%) Gaps:449/1259 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 QDADTLQAAESFGLPIVTSDTGLDILGESSDWRTFYVLDDFEGASFEAIHKQKEC-ILGPPALKY 94
            |..|.||        |:|.:..|.|  ..:| ::.|:.|.|.|..|:.: ||..| |:||..:.:
Mouse   109 QSEDYLQ--------IITDEEALKI--REND-KSLYICDRFSGTVFDHL-KQLGCRIVGPQVVTF 161

  Fly    95 AAEMKQTLGQNSRPIYNYAMRGVVTCFTGI--RKKDELTKLVNLIHSMGGCIKKDLNTKTTHLIC 157
            ....:|.:.:...|:||..|..|....|.:  .|::|:.|.|.:   |||.:.:|||...||||.
Mouse   162 CMRHQQCVPRAEHPVYNMIMSDVTVSCTSLDKDKREEVHKYVQM---MGGRVYRDLNVSVTHLIA 223

  Fly   158 NHSGGEKYQYAKTFRLTVVRPAWVFAAWADRNSLEF----DATQENFTKTHRLKAFEGQKICFFG 218
            ...|.:||..|...:..::.|:|:...|......:.    |...|:|    :...|.|..||..|
Mouse   224 GEVGSKKYLVAANLKKPILLPSWIKTLWEKSQEKKITKYTDVNMEDF----KCPIFLGCIICVTG 284

  Fly   219 FPVEEHQHMVDVLLENGG-VCAELDDPECSHVVMPNTGAVFTSTSTSTDTNPSTL---------- 272
            ......:.:..:..::|| ...:|...||:|:::..........:...:.:..||          
Mouse   285 LNGIHRKTVQQLTAKHGGQYMGQLKMNECTHLIVQEPKGQKYECARRWNVHCVTLQWFHDSIEKG 349

  Fly   273 ------INPPESQVPGSSSASQAGEEEQRKAEHLEQAEIKKMEYSHAETDNG------------M 319
                  |...|::|........:....|..||....|::     ||....||            .
Mouse   350 FCQDESIYKAETRVEAKMVPDTSTPTAQSNAESHTLADV-----SHISNINGSCVNETMFGSTTS 409

  Fly   320 SLDIDQEQKEN------QGIEDEDD------IHFDERLFVEAADIINHGE----DQLPE------ 362
            .|:...|..||      |..||..|      ..|..|...:...:||.|.    :||.|      
Mouse   410 KLECSLENLENLDISMFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVI 474

  Fly   363 -SDEED------------------------------LEEE------------------------- 371
             .|.:|                              |.||                         
Mouse   475 VGDYDDDVRQFWSKSSHRPHVVGAKWLLECFTKGYILPEESYIHTNYQPAGIAVSDQPGNQTAVL 539

  Fly   372 ------QKPKVEEVLKEQEVEEDVQA------STPKTSKIRTSLK---AATPLSS---PEMDGIA 418
                  .|..:....:.|:.:||:.|      ||...:|:..:|:   ...|.|:   |..|...
Mouse   540 DKSGSFSKSALVPAERLQQADEDLLAQYGNDDSTMVEAKLSEALEPEVGPCPGSAHREPCDDSTH 604

  Fly   419 LDFESTTQNISPILKAIDECDLETDDLPPSENDLKRKRE------SFDN---------------V 462
            :..:...::      ::..|.|  ||....|..|..::.      |.:|               |
Mouse   605 ISVQEENKS------SVSHCIL--DDSTVREEGLFSQKSFLVLGFSVENKCNIVDIIREHAGKIV 661

  Fly   463 SLMS--VDSFALPASTKKPKL-----IRTGSI-----------SRTL---RRSVSFVAEPLMKTL 506
            ||.|  |..:|:     .|.|     :..|.:           ::||   :.:..|....:|..:
Mouse   662 SLPSRIVADYAV-----VPLLGCEVDVTVGEVVTNTWLVTCIDNQTLVDPKSNPLFTPVSVMSGV 721

  Fly   507 RPRRSSVADASSFVGSEAADNSICSLASSINLTLND------------------SIRKPVKEKLR 553
            .|....|...|..||:|.  :|:..||:.:..::.:                  .:::|...|..
Mouse   722 TPLEDCVISFSQCVGAER--DSLVFLANHLGASVQEFFVRKANAKKGMLASTHLIVKEPTGSKYE 784

  Fly   554 SF---------------CGRITRSSSRRHDRGVDGTPECTTLLDSGFKTPKAPKLRSTATPKTAK 603
            :.               ..||.:.:...|           .|:|:   .||..::..|..|    
Mouse   785 AAKKWSLPAVNISWLLETARIGKRADENH-----------FLVDN---APKQEQVLETKIP---- 831

  Fly   604 RLFGPVSGVVSALTLTNPSTPTPNPNPN-----TNCTATLDVNDTSIHTFAFCAAAVT------P 657
                  :||.|     ||..|. :|:.:     ......||:|......|   .|.::      |
Mouse   832 ------NGVSS-----NPDLPA-HPDAHLEIHRKKAVTPLDMNRFQSRAF---RAVISQQRGQDP 881

  Fly   658 AMPP---------------SSSSSSSSPILSTSIAVHSSVQVIKSPEESTTRRNSPAPIEEPMAM 707
            ..||               .|...|...:...|..|..::..:::|..::.:|...:|:.|   :
Mouse   882 TFPPVRQPLTKEPSLHLDTPSKFLSKDKLFKPSFDVTDALAALETPNAASQKRKLSSPLSE---V 943

  Fly   708 VVDEHTTLTKPEPKNNHTHILKSDWFWYTIQNGYANEMDYLFGDYL-DSITNTPNTDRRDSLPIS 771
            :|...|.......:|..:|                :....|.|.:| :..|..|    .||:.:.
Mouse   944 IVRNLTVALANSSRNTDSH----------------SASPQLKGAHLEEEETRKP----LDSVVVC 988

  Fly   772 FNKRKRKRFSQRIQLEG--TPLGSGKRRSSVSDAGLLSVSNSLFDCTTSPDKLESDKLLH--AEP 832
            .:|:..|:.|   :|.|  ..||:..|.|              ||.|.:          |  .:.
Mouse   989 VSKKLSKKQS---ELNGVAASLGAEYRWS--------------FDETVT----------HFIYQG 1026

  Fly   833 EASDATPAKKSMR-------FNHFM---DFYTTESNYVGILDTILNLFKNKLEELAETND---PL 884
            .|:|:....||.:       ..|::   |..:.|.|....:.               |||   ||
Mouse  1027 RANDSNREYKSAKERGVHIVSEHWLLEPDHLSVEGNETNTMG---------------TNDKESPL 1076

  Fly   885 LNKSEIKTIFGNFLPIHEVHQSMLEHLRKLHANWREDCLIGDIIIQHRDELIKAYPPYVNFFEQM 949
            ||.|                             .|:||         :..|.:|.....||.:|:
Mouse  1077 LNGS-----------------------------GRDDC---------KGALTQALEMRENFQKQL 1103

  Fly   950 KEQLQYCDREYPRFHAFLKINQTKPECGRQGLQDLMIRPVQRLPSISLLLNDILKHTTSGNADHG 1014
            :|.:...        ..:|....|....|.........|            |..:...||.:   
Mouse  1104 QEIMSAT--------CIVKTPAQKTCMSRSSCNSASSTP------------DSARSVRSGRS--- 1145

  Fly  1015 RLEEALKAIKQVTLHINEDKRRTE 1038
            |:.|||:..:|....:|.:..:.|
Mouse  1146 RVLEALRQSRQAVPDVNTEPSQNE 1169

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pblNP_523965.2 PTCB-BRCT 117..180 CDD:289507 21/64 (33%)
RhoGEF 852..1032 CDD:279015 31/182 (17%)
PH_Ect2 1023..1186 CDD:269936 3/16 (19%)
Topbp1XP_006511769.3 BRCT_TopBP1_rpt1 183..254 CDD:349369 23/73 (32%)
BRCT_TopBP1_rpt2_like 273..349 CDD:349363 13/75 (17%)
BRCT_TopBP1_rpt3 427..508 CDD:349350 14/80 (18%)
BRCT_TopBP1_rpt4 631..714 CDD:349380 14/87 (16%)
BRCT_TopBP1_rpt5 723..811 CDD:349387 13/89 (15%)
BRCT_TopBP1_rpt6 982..1052 CDD:349359 20/96 (21%)
Streccoc_I_II <1159..>1272 CDD:411384 2/11 (18%)
PHA01732 1228..>1297 CDD:222828
BRCT_TopBP1_rpt7 1289..1363 CDD:349370
BRCT_TopBP1_rpt8 1418..1496 CDD:349360
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D305707at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.010

Return to query results.
Submit another query.