DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pbl and ect-2

DIOPT Version :9

Sequence 1:	NP_523965.2	Gene:	pbl / 38879	FlyBaseID:	FBgn0003041	Length:	1311	Species:	Drosophila melanogaster
Sequence 2:	NP_496318.1	Gene:	ect-2 / 174658	WormBaseID:	WBGene00002297	Length:	932	Species:	Caenorhabditis elegans

Alignment Length:	1050	Identity:	233/1050 - (22%)
Similarity:	383/1050 - (36%)	Gaps:	325/1050 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   422 ESTTQNISPILK-AIDECDL-ETDDLPPSENDLKRKRESFDNVSLMSVDS--------------- 469
            :|..:.|..|.| |:.:.|: :..|:.....:.|.||    |::::..||
Worm     7 QSPQKRIKTIQKLAVSKKDVHDFKDIFEMLEEQKEKR----NINIIQYDSLDDLSGDWSEYTFFC 67

  Fly   470 --------------------FALPASTKKPKLIRTGSISRTLRRSVSFVAEPLMK--TLR----- 507
                                |.:.||..|.||::...: .|||.:.....| |||  |::
Worm    68 GNFDSDLFRTLTKHQETQALFIIGASVLKNKLLKNEDL-MTLRAARPLYCE-LMKDVTMKLAAEV 130

  Fly   508 PRRSSVADASSFVGSEAADNSICSLASSINLTLNDSIRKPVKEKLRSF---------CGRITRSS 563
            |.:..:.|...::|.....:::.        ..|..|...|:.|::|.         ...:|...
Worm   131 PNKRELVDLVHYMGGSVRKDTVS--------RTNVFIAAKVEAKVQSISLVGVPTMRADWVTECW 187

  Fly   564 SRRHDRGVD------------GTPECTTLLDSGFK-TPKAPKLRSTATPKTAKRLFGPVSGVVSA 615
            ..|.|...|            |..|..:|...||| |.....|||
Worm   188 KHRDDSYFDVMEPCFVDKHRLGVFEGLSLFFHGFKQTEIDDMLRS-------------------- 232

  Fly   616 LTLTNPSTPTPNPNPNTNCTATLDVNDTSIHTFAFCAAAVTPAMPPSSSSSSSSPILSTSIAVHS 680
              |.|                                         :....:.||.|:|
Worm   233 --LEN-----------------------------------------TGGKLAPSPTLAT------ 248

  Fly   681 SVQVIKSPEESTTRRNSPAPIEEPMAMVVDEHTTLTKPEPKNNHTHILKSDWFWYTIQNGYANEM 745
              .|:.:|:.                   ||..||.   ..:|..|:.| :|||.::..|..
Worm   249 --HVVYNPDN-------------------DEVETLA---VSSNQVHVTK-EWFWVSLHRGCC--- 285

  Fly   746 DYLFGDYLDSITNTPNTDRRDSLPISFNKRKRKRFSQRIQLEGTPLGS--GKRRSSVSDAGLLSV 808
                     :|        .|:..:...|..||      .||.:.:.|  ||...|.:...|
Worm   286 ---------AI--------EDNFALPTGKLHRK------PLESSSVSSPIGKSLRSQNSRSL--- 324

  Fly   809 SNSLFDCTT--------SPDKLESDKLLHAEPEASDATPAKKSMRFNHFMDFYTTESNYVGILDT 865
             :|:.||:.        :||.:.|:.    :.|.|..:|.:.|.|....|:...||.||:.:|..
Worm   325 -SSMRDCSVEGPTSLNMTPDYIYSND----DVENSCKSPRQPSKRLRVCMEMVETEKNYLSLLKL 384

  Fly   866 ILNLFKNKLE-ELAETNDPLLNKSEIKTIFGNFLPIHEVHQSMLEHLRKL--HANWREDCLIG-- 925
            ::. ||..|| |:  :::..:::|::..:||...||.|:|:.:...|..:  .||.....:.|
Worm   385 VVK-FKEALECEI--SHNEFMSRSDVAMMFGKLDPILELHERIFARLTVMSNEANTLLTVVNGKK 446

  Fly   926 ---------DIIIQHRDELIKAYPPYVNFFEQMKEQLQYCDREYPRFHAFLKINQTKPECGRQGL 981
                     .:.|..::|:.||||.|:|.::.:|......|||..:||.|.|..::.||..|..|
Worm   447 NDDKNLDFAQVWIDAKEEMKKAYPQYINSYDTIKRLFDKQDRENSKFHTFCKAKESNPEFHRLKL 511

  Fly   982 QDLMIRPVQRLPSISLLLNDILKHTTS---GNADHGRLEEALKAIKQVTLHINEDKRRTESRMAI 1043
            .|||::|||||||:.|||.::.|.:.|   .||     |||.|||.:|....|:.:.:.::.::.
Worm   512 TDLMVKPVQRLPSVILLLKEMAKKSDSKLKNNA-----EEAAKAIDEVLKTANKTREKNDNFISH 571

  Fly  1044 FDIFNDIEGCPAHLVSSNRSFILKCEVNELSDSLSG--RGDSLVLYLFSDSIELCKRRSKGFNT- 1105
            ...|.|||..|..||::||.||.:..|:.::.:..|  :...:.|:||.|.:.:.|.||:. ||
Worm   572 LSKFTDIENVPPILVAANRMFIRELVVSPIASTSPGLQQFAKMKLFLFHDVLIITKIRSEK-NTM 635

  Fly  1106 ---AKSPSTAKTH-------KHLKLISLNTIRLVIDI-----------------SDSPRAFGLLL 1143
               |:..|.|..|       :::..|.|||:|....|                 |..|..|...|
Worm   636 QRLARHASFASLHSRQRRPYRYIDQIQLNTMRSAFRIRAPDEIAKCLELQQQNGSTKPNVFVWCL 700

  Fly  1144 ------RGDKEKLYTFTISDEETD--KSVYVKKLCNQIAAHTCRTDADKLLICRTSQELEVDISD 1200
                  .||.:.::.....:|..|  ..::||.|          :|..:........::. :|:|
Worm   701 IHRDEQGGDIDTVFESNDDEEVRDFLDDIHVKIL----------SDCGRFFYSSDPSDMN-EIND 754

  Fly  1201 VNVSTL-SKAFKLAAKTRLKVGRAFSFN------KTPNKLKRAVSTM--------MTSPFGSTNS 1250
            ..||.: ::.|:.....:.:.|.....|      .|.|:.....|.|        |...| |...
Worm   755 AMVSDMTTRYFRNLCGAKPQYGHGSQMNITVSERSTQNEWSHNESFMPPPQSQSRMRRAF-SNAQ 818

  Fly  1251 LTPASQLAQMRLASCTNINEVDDE---------DC-----ASMRS--SSPSTQSEMLVVPPLSVQ 1299
            ||.|:.|...|..|..|:.::::.         .|     |:|.|  ..|..|||....|...::
Worm   819 LTLATTLGFGRNQSRNNLGQINENTTFLQSPRVSCDPAALANMTSVGGLPGCQSESESTPKRGIR 883

  Fly  1300 PTRKNKAVVG 1309
            ....:...:|
Worm   884 SRLTSTTFLG 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pbl	NP_523965.2	PTCB-BRCT	117..180	CDD:289507
		RhoGEF	852..1032	CDD:279015	65/196 (33%)
		PH_Ect2	1023..1186	CDD:269936	47/200 (24%)
ect-2	NP_496318.1	BRCT	131..188	CDD:237994	9/64 (14%)
		BRCT	209..280	CDD:214602	28/164 (17%)
		RhoGEF	367..560	CDD:279015	66/200 (33%)
		PH-like	551..729	CDD:302622	43/178 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161755
Domainoid	1	1.000	96	1.000	Domainoid score	I4606
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5713
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007255
OrthoInspector	1	1.000	-	-		oto19620
orthoMCL	1	0.900	-	-		OOG6_104055
Panther	1	1.100	-	-	LDO	PTHR16777
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3920
SonicParanoid	1	1.000	-	-		X5358
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.820