DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pbl and ect2l

DIOPT Version :9

Sequence 1:	NP_523965.2	Gene:	pbl / 38879	FlyBaseID:	FBgn0003041	Length:	1311	Species:	Drosophila melanogaster
Sequence 2:	XP_009291443.1	Gene:	ect2l / 100332935	-ID:	-	Length:	981	Species:	Danio rerio

Alignment Length:	886	Identity:	173/886 - (19%)
Similarity:	310/886 - (34%)	Gaps:	237/886 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   438 CDLETDDLPPSENDLKRKRESFDNVSLMSVDSFALPASTKKPKLIRTGSISRTLRRSVSFVAEPL 502
            |....|.|.|        ||:.|....::.   :|.|..::....|...|.:|:|.:::...:..
Zfish   188 CAASLDILTP--------REAADVYGTLNE---SLTAPQEQEDRWREHKIRQTIRENLAEHKKAA 241

  Fly   503 MKTLRPRRSSVADASSFVGSEAADNSI----------CSLASSINLTLNDSIRKPVKEKLRSFCG 557
            :||.|...::....:||.|:.....|:          |.|.:|::   :..||||
Zfish   242 LKTRRAWLNASKLGTSFTGTIHKPLSLTAALVHLGEKCRLKNSLS---SVEIRKP---------- 293

  Fly   558 RITRSSSRRHDRGVDGTPECTTLL---DSGFKTPKAPK--------LRSTATP------------ 599
                    |.|..:..|.:.|:||   .|.|..|....        |.|:..|
Zfish   294 --------RLDLSMKSTLDSTSLLKTTSSLFNRPVMSSYYPLPHFLLVSSKVPGYELLLAAVQVS 350

  Fly   600 ----------KTAKRLFGPVSGVVSALTLTNPSTPTPNPNPNTNCTATLDVNDTS-----IHTF- 648
                      .|.:.||.....|:....|.:.....|....:...|..|.:.:.:     :..|
Zfish   351 VLVLPYDSQGMTLEVLFSLAERVIQGRMLQSVGILVPGSTDDIMLTDELRITEKTVLKPCVREFW 415

  Fly   649 -AFCAAAVTPAMPPSSSSSSSSPI--LSTSIAVHSSVQVIKSPEESTTRRNSPAPI--------- 701
             ..|...|     |:|...|.:..  |:.|:|....::.:    .:.|..|..||.
Zfish   416 EKLCGWVV-----PASEGGSLNIFAPLAASVAGMGLLRKL----STLTGLNVKAPTGICTGSYQH 471

  Fly   702 ---------EEPMAMVVDEHTTLT-----------------KPEPKNNHTHILKSD--------W 732
                     |.|..:.:.|...||                 :.||:   .|.:..:        :
Zfish   472 IVSEWCGSGEFPPLLYLHEPVLLTWCRQAEWIEEACKDLRKQLEPQ---LHFMCQEIRGRILGQF 533

  Fly   733 FWYTIQN---GYANE-MDYLFGDYLDSITNTPNTDRRDSLPISFNKRKRKRFSQRIQLEGTPLGS 793
            .|..|:.   .:.:| |:.|....:..:...|:.      ||.|                  ||.
Zfish   534 LWDRIKMPVFSFKSEVMECLVHGLVALMNEAPDD------PIDF------------------LGH 574

  Fly   794 GKRRSSVSDAGLLSVSNSLF----DCTTSPDKLESDKLLHAEPEASDATPAKKSMRFNHFMDFYT 854
            ...:||.:..||.:: :.||    ....||:. ||.|:|.::.:...|.          |.:...
Zfish   575 FLLKSSDNSNGLKNI-DPLFLTENTSVNSPNP-ESPKVLLSDADRRSAV----------FGELLN 627

  Fly   855 TESNYVGILDTILNLFKNKLEELAETNDPLLNKSEIKTIFGNFLPIHEVHQSMLEH--------- 910
            :|..||..|..:..::.:.|....::|..:::...:.|:|...|.|.|.::..:.|
Zfish   628 SERTYVRQLQAVATVYYSPLRAALDSNRAIISSVNLITLFCPLLDILETNKYNIYHFQTLSISFL 692

  Fly   911 -------------LRKLHANWRE----DCLIGDIIIQHRDELIKAYPPYVNFFEQMKEQLQYCDR 958
                         |::|...|:|    .| :||:.::....| :.|..:.|.:....:.:..|..
Zfish   693 LHSGLHYWVCSAFLKELAERWQEWSPLQC-VGDVWVKFCTRL-RVYTNFFNNYPASLKTIDKCRE 755

  Fly   959 EYPRFHAFLKINQTKPECGRQGLQDLMIRPVQRLPSISLLLNDILKHTTSGNADHGRLEEALKAI 1023
            ..|.|..|||............||:|::.|..|:.....||..:..||...:.|:.:|..||..:
Zfish   756 MLPVFRNFLKRYDRTIATRMLSLQELLLTPSARVEEYVALLQALTLHTPPEHPDYTQLTSALDTL 820

  Fly  1024 KQVTLHINEDKRRTESRMAIFDIFNDIEGCP------AHLVSSNRSFILKCEVNELSDSL----- 1077
            ......|::.|:..:..:.:.::.|.|:.||      .:|:|:....:|.|...:::.||
Zfish   821 MTYRGFIHKLKKSLDRDLRMVEVQNTIQSCPNLLEGSRYLISTQDVALLNCLNGDIAASLRMYEH 885

  Fly  1078 -SGRGDSLVLYLFSDSIELCKRRSKGFNTAKSPSTAKTHKHLKLISLNTIRLVIDISDS---PRA 1138
             |..|    |:||:|::.|.:|.........:.:|  ||..|..::|:.:.|. :|:|:   ..|
Zfish   886 VSDVG----LFLFNDALVLTERSVSSMPFCVAVNT--THTFLASVALHCLNLT-EITDTKYVQNA 943

  Fly  1139 FGLLLRGDKEKLYTFTISDEETDKSVYVKKLCNQIAAHTCR 1179
            |.|    ...|......:|.|.:|...:..|.:.|.|...|
Zfish   944 FQL----QSPKRQWICATDREEEKIRLLSALRSAINAAITR 980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pbl	NP_523965.2	PTCB-BRCT	117..180	CDD:289507
		RhoGEF	852..1032	CDD:279015	42/205 (20%)
		PH_Ect2	1023..1186	CDD:269936	39/172 (23%)
ect2l	XP_009291443.1	F-box-like	121..164	CDD:289689
		DUF4347	331..>468	CDD:290951	24/145 (17%)
		Dpy-30	546..578	CDD:253069	9/55 (16%)
		RhoGEF	624..829	CDD:279015	42/206 (20%)
		PH-like	<893..980	CDD:302622	23/93 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810