DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pbl and Ect2l

DIOPT Version :9

Sequence 1:	NP_523965.2	Gene:	pbl / 38879	FlyBaseID:	FBgn0003041	Length:	1311	Species:	Drosophila melanogaster
Sequence 2:	NP_001357920.1	Gene:	Ect2l / 100045792	MGIID:	3641723	Length:	953	Species:	Mus musculus

Alignment Length:	929	Identity:	202/929 - (21%)
Similarity:	341/929 - (36%)	Gaps:	254/929 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   348 EAADIINHGEDQLPESDEEDLEEEQKPK-VEEVLKEQ---EVEEDVQASTPKTSKIRTS--LKAA 406
            |||.:  :|....|::::|:.:|.::.| :.:::.|.   ..:|..:|..|..|..|.|  ||:.
Mouse   171 EAAAV--YGTLNEPKTEDEEFQERRREKCLRKIIWENIAFRKKELFKARPPWLSGTRCSRLLKST 233

  Fly   407 TPLSSPEM--DGIALDFESTTQNISPILKAIDECDLETDDLPPSENDLKRKRESFDNVSLMSVDS 469
            :....|::  ||... :|:..:.   .|:|      ..|.||        ||   .|:|    .|
Mouse   234 SLPGGPQLWRDGTGF-YEALERQ---FLRA------SLDALP--------KR---SNIS----GS 273

  Fly   470 FALPASTKKPKLIRTGSISRT--------LRRSVSFVAEPLMKTLRPRRSSVADASSFVGSEAAD 526
            .:.|...||    ....:.||        |..|.....|.:|::::|...:|....|.|..|..
Mouse   274 HSYPLLLKK----HHHGVGRTDALPLHAILISSRIPAYEMVMESIKPDVVAVLYEHSGVTLEGL- 333

  Fly   527 NSICSLASSINLTLNDSIRKPVKEKLRSFCGRITRS---SSRRHDRGVD---GTPECTTLLDSGF 585
                       |.|.|          |:..||..:|   .|..:.|.:|   |...|       .
Mouse   334 -----------LQLTD----------RALQGRKAQSLGIFSSGNSREIDLLQGYKIC-------I 370

  Fly   586 KTPKAPKLRS--------TATPKTAKR--LFGPV----SGV-----VSALTLTNPSTPTPNPNPN 631
            |....|::|.        .||.:....  ||.|:    :|:     :|.||.|..|.||
Mouse   371 KNVLWPEVRDFWEKLGSRVATEEEGGHVDLFVPLGASEAGIEVLSQLSQLTGTWFSAPT------ 429

  Fly   632 TNCTATLDVNDTSIHTFAFCAAAVTPAMPPSSSSSSSSPILSTSIAVHSSVQVIKSPEESTTRRN 696
                                          ..::.|...|||..:..|..
Mouse   430 ------------------------------GIATGSYQHILSDWLGPHQD--------------- 449

  Fly   697 SPAPIEEPMAMVVDEHTTLTKPEPKNNHTHILKS---------DWFWYTIQNGYANEM--DYLFG 750
                 ..|::....|    :|.:..::.|..|:.         :..:..:|...:..|  .::|.
Mouse   450 -----RTPLSNYFSE----SKLQAWSSFTEFLEDTLKSVRKTLNPLFKNLQKSISGRMIGQFMFD 505

  Fly   751 DY-LDSITNT--PNTDRRDSL----------PISF--------NKRKRKRFS-----QRIQLEGT 789
            .. :|||.|.  |.....|.|          |:.|        :.:..|.|.     ....|:.|
Mouse   506 TLGMDSILNNQGPAQALADGLMELSKEGSDKPLEFLSYFLLKKSSKTNKDFEGNYVLAECDLKET 570

  Fly   790 PLGSGKRRSSVSDAGLLSVSNSLFDCTTSP--DKLESDKLLHAEPEASDATPAKKSMRFNH---- 848
            .....|..|::.|       ||. |..:||  ..|..:.|:..|          :.::.|.
Mouse   571 QDALMKEGSAIED-------NSQ-DSKSSPGQSNLNVEVLVKLE----------RKLQMNSVETR 617

  Fly   849 ---FMDFYTTESNYVGILDTILNLFKNKLEELAETNDPLLNKSEIKTIFGNFLPIHEVHQSMLEH 910
               ..:...:|..||.:|..:.:::...|.....:|..:|:.:.|..||.:.|.|..:::..|::
Mouse   618 AQVVRELVQSERRYVQMLRIVQDVYAKPLRAALSSNRAILSAANIHIIFSDILHILNLNREFLDN 682

  Fly   911 LRKLHANWREDCLIGDIIIQHRDELIKAYPPYVNFFEQMKEQLQYCDREYPRFHAFLKINQTKPE 975
            ||.....|.....:|:|.|:...:| ..|..:.|.:..:.:.::.|....|.|.||||.:.....
Mouse   683 LRDRLQEWSPAHCVGEIFIKFGSQL-NIYTNFFNNYPVVLKTIEKCREMTPAFRAFLKRHDKTIV 746

  Fly   976 CGRQGLQDLMIRPVQRLPSISLLLNDILKHTTSGNADHGRLEEALKAIKQVTLHINEDKRRTESR 1040
            .....|.:|:|.|.:|......||..:..||.:|:.|.|.|..|:..:|:...:|::.|...:.|
Mouse   747 TKMLSLPELLIYPSRRFEEYIHLLYALRLHTPAGHVDRGDLTTAIDQVKKYKGYIDQIKENLKMR 811

  Fly  1041 MAIFDIFNDIEGCPAHLVSSNRSFI-------LKC--EVNELSDSLSGRGDSLVLYLFSDSIELC 1096
            ..:.|:...|.|||. |..:||..|       |.|  |..:.|..|..:...|.|.||:|.:.:.
Mouse   812 EQLSDVQTLICGCPT-LSEANRYLIRTQDVVQLHCCDEKMDFSLRLYEQIRDLSLLLFNDVLLVS 875

  Fly  1097 KRRSKGFNTAKSP--STAK-THKHLKLISLNTIRLVIDISDS---PRAFGLLLRGDKEKLYTFT- 1154
            .|     :|:.:|  .|:| |::....::|..: |:.||.||   ..||  :|||.|.:....|
Mouse   876 SR-----STSHTPFEKTSKTTYQFTASVALPRL-LIEDIPDSKYIKNAF--ILRGSKREWICATE 932

  Fly  1155 ISDEETDKSVYVKKLCNQI 1173
            :||   ||.:::..|.:.|
Mouse   933 VSD---DKFLWLSVLQHAI 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pbl	NP_523965.2	PTCB-BRCT	117..180	CDD:289507
		RhoGEF	852..1032	CDD:279015	45/179 (25%)
		PH_Ect2	1023..1186	CDD:269936	48/167 (29%)
Ect2l	NP_001357920.1	F-box-like	93..130	CDD:372399
		DUF4347	298..467	CDD:372982	45/257 (18%)
		RhoGEF	620..802	CDD:366202	44/182 (24%)
		PH-like	832..952	CDD:388408	37/128 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810