DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4E5 and eif4e2

DIOPT Version :9

Sequence 1:	NP_648160.2	Gene:	eIF4E5 / 38878	FlyBaseID:	FBgn0035823	Length:	232	Species:	Drosophila melanogaster
Sequence 2:	NP_001014815.2	Gene:	eif4e2 / 541523	ZFINID:	ZDB-GENE-050327-59	Length:	236	Species:	Danio rerio

Alignment Length:	227	Identity:	70/227 - (30%)
Similarity:	118/227 - (51%)	Gaps:	27/227 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FDIMKQQD--QQHQLNSIHKHHHHHEGVPLESNSPEPIDEEIYQVEYK--------HPLEHVWTL 63
            ||.:|..|  ...|.||..|....      |.|..|  |:|....:.|        |||::.:|.
Zfish     5 FDALKDDDSGDHDQDNSSPKDGEK------EKNDEE--DKEANTTKRKAVVPGAGEHPLQYNYTF 61

  Fly    64 WYLEND-----RTKHWKDMLNEITEIDSVETFWSLYHTIKTPAELKIGCDYSVFKKGIKPMWEDE 123
            ||....     .|:.::..:.:|....|||.||..|..:..|.:|....|:.:||:||||||||:
Zfish    62 WYSRRTPGRPASTQSYEQNIKQIGSFASVEQFWRFYSHMIRPGDLTGHSDFHLFKEGIKPMWEDD 126

  Fly   124 ANIKGGRWLVTVSKSAKAELDQIWLDILLLMVGQNFEYSDEICGAVINIRNKSNKISVWTANGSN 188
            ||..||:|::.:.|...:   :.|.:::|.|:|:.|...:||||||:::|.:.:.||:|....|:
Zfish   127 ANKSGGKWIIRLRKGLAS---RCWENLILAMLGEQFMVGEEICGAVVSVRFQEDIISIWNKTASD 188

  Fly   189 EMAILEIGQKLKILLHLQSHS-LQYQLHSDAM 219
            :.....|...|:.:|:|..:: ::|:.|:|::
Zfish   189 QATTARIRDTLRRVLNLPPNTIMEYKTHTDSI 220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4E5	NP_648160.2	IF4E	59..212	CDD:279921	50/158 (32%)
eif4e2	NP_001014815.2	IF4E	54..212	CDD:307672	52/160 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573584
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5053
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54586
OrthoDB	1	1.010	-	-		D1394271at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.760