DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF4E5 and eif4eb

DIOPT Version :9

Sequence 1:	NP_648160.2	Gene:	eIF4E5 / 38878	FlyBaseID:	FBgn0035823	Length:	232	Species:	Drosophila melanogaster
Sequence 2:	NP_001007778.1	Gene:	eif4eb / 493617	ZFINID:	ZDB-GENE-041121-14	Length:	216	Species:	Danio rerio

Alignment Length:	204	Identity:	89/204 - (43%)
Similarity:	137/204 - (67%)	Gaps:	7/204 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 EGVPLESNSPEPIDEEIYQVEYKHPLEHVWTLWYLENDRTKHWKDMLNEITEIDSVETFWSLYHT 96
            |.:..|||. |.:..|.|   .||||::.|.||:.:||::|.|:..|..|::.|:||.||:||:.
Zfish    17 EEISDESNQ-EIVSPESY---IKHPLQNRWCLWFFKNDKSKTWQANLRLISKFDTVEDFWALYNH 77

  Fly    97 IKTPAELKIGCDYSVFKKGIKPMWEDEANIKGGRWLVTVSK-SAKAELDQIWLDILLLMVGQNF- 159
            |:..:.|..|||||:||.||:||||||.|.:|||||:|::| ..|.:||:.||:.||.::|:.|
Zfish    78 IQLSSNLMSGCDYSLFKDGIEPMWEDERNKRGGRWLITLNKQQRKYDLDRFWLETLLCLIGEAFD 142

  Fly   160 EYSDEICGAVINIRNKSNKISVWTANGSNEMAILEIGQKLKILLHL-QSHSLQYQLHSDAMSKFN 223
            :|||::||||:|:|.|.:||::|||:..|..|:..||:..|..|.: .:.::.||.|:|..:|..
Zfish   143 DYSDDVCGAVVNVRTKGDKIAIWTADYGNREAVTHIGRVYKERLGVPMNMTIGYQSHADTATKSG 207

  Fly   224 SGVKSVYTL 232
            |..|:.:.:
Zfish   208 STTKNKFVV 216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4E5	NP_648160.2	IF4E	59..212	CDD:279921	71/155 (46%)
eif4eb	NP_001007778.1	IF4E	40..196	CDD:279921	71/155 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573566
Domainoid	1	1.000	193	1.000	Domainoid score	I3137
eggNOG	1	0.900	-	-		E1_COG5053
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H123817
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3585
OMA	1	1.010	-	-		QHG54586
OrthoDB	1	1.010	-	-		D1394271at2759
OrthoFinder	1	1.000	-	-		FOG0000666
OrthoInspector	1	1.000	-	-		mtm6577
orthoMCL	1	0.900	-	-		OOG6_100627
Panther	1	1.100	-	-	O	PTHR11960
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X406
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770