back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF4E5 and EIF4E3

DIOPT Version :9

Sequence 1:	NP_648160.2	Gene:	eIF4E5 / 38878	FlyBaseID:	FBgn0035823	Length:	232	Species:	Drosophila melanogaster
Sequence 2:	NP_001128123.1	Gene:	EIF4E3 / 317649	HGNCID:	31837	Length:	224	Species:	Homo sapiens

Alignment Length:	171	Identity:	48/171 - (28%)
Similarity:	86/171 - (50%)	Gaps:	14/171 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 PLEHVWTLWY---LENDRTKHWKDMLNEITEIDSVETFWSLYHTIKTPAELKIGCDYSVFKKGIK 117
            ||...||.|.   |...........|.:|..:.:|:.|||:|:.|.....|.:.|.|.:.:...:
Human    48 PLHSSWTFWLDRSLPGATAAECASNLKKIYTVQTVQIFWSVYNNIPPVTSLPLRCSYHLMRGERR 112

  Fly   118 PMWEDEANIKGGRWLVTVSKSAKAELDQIWLDILLLMVGQNF----EYSDEICGAVINIRNKSNK 178
            |:||:|:|.|||.|.:.|.|.:.:   .:|.::||..:|:.|    ...||:.|..:::|::.:.
Human   113 PLWEEESNAKGGVWKMKVPKDSTS---TVWKELLLATIGEQFTDCAAADDEVIGVSVSVRDREDV 174

  Fly   179 ISVWTANGS--NEMAILEIGQKLKILLHLQSHSLQYQLHSD 217
            :.||..|.|  .|..:||  :..::|.|:...::.|:.|.:
Human   175 VQVWNVNASLVGEATVLE--KIYELLPHITFKAVFYKPHEE 213

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.