DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4E5 and Eif4e2

DIOPT Version :9

Sequence 1:	NP_648160.2	Gene:	eIF4E5 / 38878	FlyBaseID:	FBgn0035823	Length:	232	Species:	Drosophila melanogaster
Sequence 2:	XP_036021474.1	Gene:	Eif4e2 / 26987	MGIID:	1914440	Length:	265	Species:	Mus musculus

Alignment Length:	230	Identity:	67/230 - (29%)
Similarity:	118/230 - (51%)	Gaps:	30/230 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FDIMKQQDQQHQLNSIHKHHHHHEGVPLESNSPEPIDEEIYQVEYK----------HPLEHVWTL 63
            ||.:|..|.       ..|..:.|....:....|..|.:..|...|          |||::.:|.
Mouse     5 FDALKDDDS-------GDHDQNEENSTQKDGEKEKTDRDKSQSSGKRKAVVPGPAEHPLQYNYTF 62

  Fly    64 WYLENDRT-------KHWKDMLNEITEIDSVETFWSLYHTIKTPAELKIGCDYSVFKKGIKPMWE 121
            ||  :.||       :.::..:.:|....|||.||..|..:..|.:|....|:.:||:|||||||
Mouse    63 WY--SRRTPGRPTSSQSYEQNIKQIGTFASVEQFWKFYSHMVRPGDLTGHSDFHLFKEGIKPMWE 125

  Fly   122 DEANIKGGRWLVTVSKSAKAELDQIWLDILLLMVGQNFEYSDEICGAVINIRNKSNKISVWTANG 186
            |:||..||:|::.:.|...:   :.|.:::|.|:|:.|...:||||||:::|.:.:.||:|....
Mouse   126 DDANKNGGKWIIRLRKGLAS---RCWENLILAMLGEQFMVGEEICGAVVSVRFQEDIISIWNKTA 187

  Fly   187 SNEMAILEIGQKLKILLHLQSHS-LQYQLHSDAMS 220
            |::.....|...|:.:|:|..:: ::|:.|:|:::
Mouse   188 SDQATTARIRDTLRRVLNLPPNTIMEYKTHTDSIN 222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4E5	NP_648160.2	IF4E	59..212	CDD:279921	51/160 (32%)
Eif4e2	XP_036021474.1	IF4E	55..214	CDD:396291	53/163 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830816
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5053
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54586
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750