DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4E5 and Eif4e1b

DIOPT Version :9

Sequence 1:	NP_648160.2	Gene:	eIF4E5 / 38878	FlyBaseID:	FBgn0035823	Length:	232	Species:	Drosophila melanogaster
Sequence 2:	NP_001273108.1	Gene:	Eif4e1b / 218268	MGIID:	2685119	Length:	250	Species:	Mus musculus

Alignment Length:	202	Identity:	83/202 - (41%)
Similarity:	130/202 - (64%)	Gaps:	18/202 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KHHHHHEGVPLESNSPEPIDEEIYQVEYKHPLEHVWTLWYLENDRTKHWKDMLNEITEIDSVETF 90
            |.|..|        .||.:.:       .|||::.|.||:.:|||::.|:|.|..:|:.::||.|
Mouse    57 KAHREH--------PPEVLSK-------LHPLQYRWVLWFFKNDRSRAWQDNLQLVTKFNTVEDF 106

  Fly    91 WSLYHTIKTPAELKIGCDYSVFKKGIKPMWEDEANIKGGRWLVTVSKSAK-AELDQIWLDILLLM 154
            |::|..||..::|..||||::||:||.|||||..|.:|||||:::.|..: .|||::||:.||.:
Mouse   107 WAVYSHIKLASKLSSGCDYALFKEGILPMWEDNRNKQGGRWLLSIDKQLRHFELDRLWLETLLCL 171

  Fly   155 VGQNF-EYSDEICGAVINIRNKSNKISVWTANGSNEMAILEIGQKLKILLHLQSHS-LQYQLHSD 217
            ||..| |||.|:||||:|||.|.:||::||:...::..:::|||..|..|.:.:.: :.||.|:|
Mouse   172 VGNCFEEYSREVCGAVVNIRTKRDKIALWTSEAEDKAGVMQIGQIYKERLGISTKTIIGYQAHAD 236

  Fly   218 AMSKFNS 224
            ..:|.|:
Mouse   237 TAAKSNN 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4E5	NP_648160.2	IF4E	59..212	CDD:279921	69/155 (45%)
Eif4e1b	NP_001273108.1	IF4E	75..231	CDD:279921	69/155 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830795
Domainoid	1	1.000	186	1.000	Domainoid score	I3337
eggNOG	1	0.900	-	-		E1_COG5053
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	215	1.000	Inparanoid score	I3600
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54586
OrthoDB	1	1.010	-	-		D1394271at2759
OrthoFinder	1	1.000	-	-		FOG0000666
OrthoInspector	1	1.000	-	-		mtm8694
orthoMCL	1	0.900	-	-		OOG6_100627
Panther	1	1.100	-	-	O	PTHR11960
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X406
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770