DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4E5 and EIF4E

DIOPT Version :9

Sequence 1:	NP_648160.2	Gene:	eIF4E5 / 38878	FlyBaseID:	FBgn0035823	Length:	232	Species:	Drosophila melanogaster
Sequence 2:	NP_001124151.1	Gene:	EIF4E / 1977	HGNCID:	3287	Length:	248	Species:	Homo sapiens

Alignment Length:	232	Identity:	86/232 - (37%)
Similarity:	134/232 - (57%)	Gaps:	42/232 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 ESNSPEPIDEEIYQVEY--KHPLEHVWTLWYLENDRTKHWKDMLNEITEIDSVETFWSLYHTIKT 99
            |||      :|:...|:  ||||::.|.||:.:||::|.|:..|..|::.|:||.||:||:.|:.
Human    23 ESN------QEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQL 81

  Fly   100 PAELKIGCDYSVFKKGIKPMWEDEANIKGGRWLVTVSK-SAKAELDQIWLDI------------- 150
            .:.|..|||||:||.||:||||||.|.:|||||:|::| ..:::||:.||:.
Human    82 SSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETRWDLAMLPRLVSN 146

  Fly   151 ------------------LLLMVGQNF-EYSDEICGAVINIRNKSNKISVWTANGSNEMAILEIG 196
                              ||.::|::| :|||::||||:|:|.|.:||::||....|..|:..||
Human   147 FWPQVILPLQPPKVLELQLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIG 211

  Fly   197 QKLKILLHLQSH-SLQYQLHSDAMSKFNSGVKSVYTL 232
            :..|..|.|... .:.||.|:|..:|..|..|:.:.:
Human   212 RVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4E5	NP_648160.2	IF4E	59..212	CDD:279921	70/186 (38%)
EIF4E	NP_001124151.1	IF4E	38..228	CDD:366742	72/189 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140841
Domainoid	1	1.000	187	1.000	Domainoid score	I3336
eggNOG	1	0.900	-	-		E1_COG5053
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H123817
Inparanoid	1	1.050	214	1.000	Inparanoid score	I3630
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54586
OrthoDB	1	1.010	-	-		D1394271at2759
OrthoFinder	1	1.000	-	-		FOG0000666
OrthoInspector	1	1.000	-	-		mtm8454
orthoMCL	1	0.900	-	-		OOG6_100627
Panther	1	1.100	-	-	O	PTHR11960
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X406
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770