Protein Alignment CAPN8 and capn8

DIOPT Version :10

• Sequence 1: NP_001137434.1
• Gene: CAPN8 / 388743
• HGNCID: 1485
• Length: 703
• Species: Homo sapiens
• Sequence 2: NP_001231009.2
• Gene: capn8 / 337730
• ZFINID: ZDB-GENE-050522-279
• Length: 700
• Species: Danio rerio
• Alignment Length: 702
• Identity: 396/702 - (56%)
• Similarity: 538/702 - (76%)
• Gaps: 3/702 - (0%)

Human     1 MAAQAAGVSRQRAATQGLGSNQNALKYLGQDFKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGP 65
            |:..|..:||::...:|||:|:.|:.|..||:::|:|:||....||.||.|||...:|||.:||.
Zfish     1 MSNIAKVLSRRQDRGEGLGTNEKAIPYNKQDYQSLKQECLAKRALFCDPTFPAESDSLGYNELGR 65

Human    66 GSPQTQGIIWKRPTELCPSPQFIVGGATRTDICQGGLGDCWLLAAIASLTLNEELLYRVVPRDQD 130
            .|.:|:|:.||||.|||.:|:||:.||.|||||||.|||||||||||||||::|:|.||||..|.
Zfish    66 YSFKTKGVQWKRPKELCSNPEFIMDGANRTDICQGALGDCWLLAAIASLTLDKEILERVVPSGQS 130

Human   131 FQENYAGIFHFQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEQGNEFWSALLEKAYAKLNGCYEAL 195
            |.|:||||||||||||||||:|||||||||::|:|||:||.:|:|||||||||||||:||.||||
Zfish   131 FTEDYAGIFHFQFWQYGEWVDVVIDDRLPTRDGKLLFVHSAEGSEFWSALLEKAYAKVNGSYEAL 195

Human   196 AGGSTVEGFEDFTGGISEFYDLKKPPANLYQIIRKALCAGSLLGCSIDVSSAAEAEAITSQKLVK 260
            .||||.||||||||||:|.|:|.|.|.||:::::|||..|||||||||::::.|.||:||.||||
Zfish   196 TGGSTTEGFEDFTGGITENYELSKAPPNLFKLVQKALALGSLLGCSIDITNSYETEAVTSLKLVK 260

Human   261 SHAYSVTGVEEVNFQGHPEKLIRLRNPWGEVEWSGAWSDDAPEWNHIDPRRKEELDKKVEDGEFW 325
            .||||||..|||:|:|...:|:|:|||||||||:|||||::.||:.:.|..|.:||...||||||
Zfish   261 GHAYSVTAAEEVHFRGSLVQLVRIRNPWGEVEWTGAWSDNSKEWDSVRPEEKAKLDYSAEDGEFW 325

Human   326 MSLSDFVRQFSRLEICNLSPDSLSSEEVHKWNLVLFNGHWTRGSTAGGCQNYPATYWTNPQFKIR 390
            |:.|||::|||:||||||:||:||||||::|:...|.|:|..|||||||:|.|||:.:||||.|:
Zfish   326 MAYSDFIQQFSKLEICNLTPDTLSSEEVNRWSYSQFEGNWRVGSTAGGCRNNPATFCSNPQFMIK 390

Human   391 LDEVDEDQEESIGEPCCTVLLGLMQKNRRWRKRIGQGMLSIGYAVYQVPKELESHTDAHLGRDFF 455
            |:|:|:|..:.:..  ||.|:||:||:.|..||.|:.:.:||:|:|:||.||:..::.|||.|..
Zfish   391 LEEIDDDPHDGVNG--CTFLVGLIQKDGRKDKRFGRDLNTIGFAIYKVPDELKGRSNIHLGPDVL 453

Human   456 LAYQPSARTSTYVNLREVSGRARLPPGEYLVVPSTFEPFKDGEFCLRVFSEKKAQALEIGDVVAG 520
            |..:..|.::|::||||||.|.:||||||:::||||||.:.|.|.||||:||:|.|.:||..::.
Zfish   454 LRQRSVAGSNTFINLREVSERFKLPPGEYIIIPSTFEPHRKGSFILRVFAEKEADASQIGTEISA 518

Human   521 NPYEPHPSEVDQEDDQFRRLFEKLAGKDSEITANALKILLNEAFSKRTDIKFDGFNINTCREMIS 585
            :..:...||.| .|..|:|||.::||.|||::...|:.:||...|||:::|.|||::.|||.:||
Zfish   519 DVKKHFISEKD-IDPHFKRLFSQVAGSDSEVSVLELQQILNTVVSKRSNVKTDGFSLETCRHIIS 582

Human   586 LLDSNGTGTLGAVEFKTLWLKIQKYLEIYWETDYNHSGTIDAHEMRTALRKAGFTLNSQVQQTIA 650
            |||.:|:|.||.:||.|||:||||||||:...|.::|||:.:.|||.|:::|||.||:.|.:.:.
Zfish   583 LLDKDGSGKLGLLEFHTLWMKIQKYLEIFKHRDTDNSGTMSSLEMRDAVKEAGFQLNNDVLEVLI 647

Human   651 LRYACSKLGINFDSFVACMIRLETLFKLFSLLDEDKDGMVQLSLAEWLCCVL 702
            .|||..:..|:|||||:|:||||.|||:|.|.|:...|.::|.:.:|||..|
Zfish   648 ARYANQEYAIDFDSFVSCLIRLELLFKMFQLFDKKNTGKIELDILQWLCLAL 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAPN8	NP_001137434.1	Peptidase_C2	46..342	CDD:459889	199/295 (67%)
		Calpain_III	354..514	CDD:238132	79/159 (50%)
		Domain III	356..379		12/22 (55%)
		EFh_PEF_CAPN8	536..703	CDD:320066	84/167 (50%)
		EF-hand motif	536..564	CDD:320066	12/27 (44%)
		EF-hand motif	578..608	CDD:320066	18/29 (62%)
		EF-hand motif	609..639	CDD:320066	14/29 (48%)
		EF-hand motif	645..673	CDD:320066	13/27 (48%)
		EF-hand motif	674..703	CDD:320066	12/29 (41%)
capn8	NP_001231009.2	None