DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG32369 and LONRF1

DIOPT Version :10

Sequence 1:NP_729296.1 Gene:CG32369 / 38873 FlyBaseID:FBgn0052369 Length:1066 Species:Drosophila melanogaster
Sequence 2:NP_689484.3 Gene:LONRF1 / 91694 HGNCID:26302 Length:773 Species:Homo sapiens


Alignment Length:849 Identity:222/849 - (26%)
Similarity:347/849 - (40%) Gaps:232/849 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   181 LMCPLCSDILRCPVTTNCGHTFCRQCC--ETITQCNICQVRFPRIQASSPGPPVCALTTTTASGA 243
            |.|..|...|..|||..|||::||:|.  |...:|.:|:.|.|...||:          |.|.| 
Human   121 LRCLGCRGFLSEPVTVPCGHSYCRRCLRRELRARCRLCRDRLPPATASA----------TDAEG- 174

  Fly   244 GSSLFTAPSNHNANLSLISFPVGYGVQLSSSVQRLAAPPMTVTTTTVASTTATATTTMASTSAAA 308
                 |||                           ..||:                       ||
Human   175 -----TAP---------------------------RPPPL-----------------------AA 184

  Fly   309 ALGLSAYPSAHGGGIGSTAMKFMPDVLVRRLVEKWWGPDLQAKKISEKASSCMHLNLLDDALKFC 373
            |:               .|..|...|::..|.|||:....:..:.:.:....:|.....:||...
Human   185 AI---------------AASDFRTSVVLNHLAEKWFPGQRERARAAGRLGELLHQGRYREALAAA 234

  Fly   374 NASLEKSPANFKSLCLRAEVLLKLSHYQSSLADIENALRTRCTSPKAHYLRALALSGLGRLEEAL 438
            ..:|...|::......|||....|..:::::.|:...|......|:.::.:...|...|.|.:||
Human   235 CEALRAEPSDLIVKIYRAESYAGLQEFKAAIEDLNAVLFQLPDWPEVYFRKGKVLCDAGFLGDAL 299

  Fly   439 YNGFLAICLDKKTNLSNSEIFQHDLAKILQRLLAHMPKN-RTSLSSATVPVFQQQHRNFATSRAP 502
            ......:.||:....:..::     .|||..||  :|:| :..|..::                 
Human   300 QLFLQCLALDEDFAPAKLQV-----QKILCDLL--LPENLKEGLKESS----------------- 340

  Fly   503 YPLLWEQVRRRRKQQHHHHHHHHHHHVHLDDVEDEFGHYNNYIMAGDDMEEEVEVEVEGGEP--G 565
                |..:...:.:....|           .|.:|....|.     ...::..|:.....||  |
Human   341 ----WSSLPCTKNRPFDFH-----------SVMEESQSLNE-----PSPKQSEEIPEVTSEPVKG 385

  Fly   566 SLHLD------GDFLFPSALDFMDHHRHQRHVFEQKQFDLQPRRHANRKH--CKRKWSVAMESMG 622
            ||:..      .....|:..|.:            |:...:|......|.  .|||.|       
Human   386 SLNRAQSAQSINSTEMPAREDCL------------KRVSSEPVLSVQEKGVLLKRKLS------- 431

  Fly   623 GKDLEEEDVDRAHAAGESQRCSRLFAGVLDRTQQELQRLKKLDKSAP-----SLAVSSVAGQLID 682
               |.|:||    ...|..|                .:|||..::..     |||...:..:|||
Human   432 ---LLEQDV----IVNEDGR----------------NKLKKQGETPNEVCMFSLAYGDIPEELID 473

  Fly   683 ASDFDCVVCSRTLWKPVVTPCGHTYCLVCLDRCMDYNSPCPLCMSPLVEFNVNASASTSASQHPN 747
            .|||:|.:|.|..::||.|||||::|..||:||:|:...||||...|.|:               
Human   474 VSDFECSLCMRLFFEPVTTPCGHSFCKNCLERCLDHAPYCPLCKESLKEY--------------- 523

  Fly   748 PNQNQIHLHPGSSSPVPFALAKRP--VTKFLEAAMKRFIPDHYEARFRQEIDQE--------PSV 802
                               ||.|.  ||:.||..:.:::||....| ::..|:|        .:|
Human   524 -------------------LADRRYCVTQLLEELIVKYLPDELSER-KKIYDEETAELSHLTKNV 568

  Fly   803 PVFICTAAFPAVPCPLFVCEPRYRLMVRRAVESGDKTFGIVQPNGGKSRYYDVGTILDIRDCVQL 867
            |:|:||.|:|.|||||.|.|||||||:||::::|.|.||:...:...| :.|.|.:|.||:...|
Human   569 PIFVCTMAYPTVPCPLHVFEPRYRLMIRRSIQTGTKQFGMCVSDTQNS-FADYGCMLQIRNVHFL 632

  Fly   868 GDGCSILSTIGCKRFKILARNEKDGYETAKVEYICDEPIADE-QVKILAGMQGVVLAKASEWFES 931
            .||.|::.|:|.|||::|.|..||||.||.:||:.|..:.:| ::|.|..:..:|.::|..||::
Human   633 PDGRSVVDTVGGKRFRVLKRGMKDGYCTADIEYLEDVKVENEDEIKNLRELHDLVYSQACSWFQN 697

  Fly   932 LSTEQKHEILQSFGQMPPLEPNWELISDGPAWAWWIIALLPLSQQLKVDILATTSLEKRLRAIDK 996
            |....:.:|||.||.||..|.|.:...:||||.||::|:||:..:.::.:|:..||::||..|..
Human   698 LRDRFRSQILQHFGSMPEREENLQAAPNGPAWCWWLLAVLPVDPRYQLSVLSMKSLKERLTKIQH 762

  Fly   997 TLDW 1000
            .|.:
Human   763 ILTY 766

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32369NP_729296.1 RING_Ubox 179..222 CDD:473075 17/42 (40%)
TPR repeat 350..378 CDD:276809 3/27 (11%)
TPR 357..>438 CDD:440225 15/80 (19%)
Spy 363..>517 CDD:443119 27/154 (18%)
TPR repeat 383..413 CDD:276809 6/29 (21%)
RING-HC_LONFs_rpt2 685..729 CDD:438177 22/43 (51%)
LON/PUA 811..999 CDD:442054 78/188 (41%)
LONRF1NP_689484.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..29
TPR 1 48..81
RING_Ubox 120..165 CDD:473075 18/43 (42%)
Spy 197..>328 CDD:443119 28/137 (20%)
TPR 2 212..244 5/31 (16%)
TPR repeat 212..239 CDD:276809 3/26 (12%)
TPR 3 246..278 6/31 (19%)
TPR repeat 247..273 CDD:276809 5/25 (20%)
TPR repeat 278..308 CDD:276809 6/29 (21%)
TPR 4 279..312 8/32 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 359..388 7/33 (21%)
PEX10 <420..527 CDD:227861 47/170 (28%)
RING-HC_LONFs_rpt2 476..520 CDD:438177 22/43 (51%)
LON_substr_bdg 567..765 CDD:426647 84/198 (42%)
Blue background indicates that the domain is not in the aligned region.

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