DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32369 and RAD18

DIOPT Version :9

Sequence 1:	NP_001246660.1	Gene:	CG32369 / 38873	FlyBaseID:	FBgn0052369	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	NP_009992.1	Gene:	RAD18 / 850430	SGDID:	S000000662	Length:	487	Species:	Saccharomyces cerevisiae

Alignment Length:	413	Identity:	89/413 - (21%)
Similarity:	141/413 - (34%)	Gaps:	151/413 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   679 QLIDASDFD---------------CVVCSRTLWKPVVTPCGHTYCLVCLDRCMDYNSPCPLCM-- 726
            |:..||||.               |.:|...|..||:||||||:|.:|:...::....||||:
Yeast     4 QITTASDFTTTSIPSLYQLDTLLRCHICKDFLKVPVLTPCGHTFCSLCIRTHLNNQPNCPLCLFE 68

  Fly   727 ------------SPLVE-FNVNASASTSASQHPNP-------------NQNQIHLHPGSSSPVPF 765
                        |.::: :....|:...|.:.|.|             |.:.|.|...|.|....
Yeast    69 FRESLLRSEFLVSEIIQSYTSLRSSLLDALRIPKPTPVPENEEVPGPENSSWIELISESESDSVN 133

  Fly   766 A--------------LAKRPVTKFLEAAMKRFIPDHYE-ARFRQEIDQEPSVPVFICTAAFPAVP 815
            |              ||||.:|..|..:.|   |.... |.||.|..::.|.|      ......
Yeast   134 AADDDLQIVATSERKLAKRSMTDILPLSSK---PSKRNFAMFRSERIKKKSKP------NEQMAQ 189

  Fly   816 CPLFVCEPRYRLMVRRAVESGDKTFGIVQPNGGKSRYYDVGTILDIRDCV---QLGDGCSILSTI 877
            ||  :|:..|.|   :|:|.                     |.||  :|:   .||....|.:|.
Yeast   190 CP--ICQQFYPL---KALEK---------------------THLD--ECLTLQSLGKKPKISTTF 226

  Fly   878 ---------GCKRFKILARNEKDGYETAKVEYICDEPIADEQVKILAGMQGVVLAKASEWFESLS 933
                     ...|||: ...|.|.....:..::      |:.:..:...:...|.|.:  |.|::
Yeast   227 PTESNPHNKSSSRFKV-RTPEVDKSSCGETSHV------DKYLNSMMSAEHQRLPKIN--FTSMT 282

  Fly   934 TEQKHEILQSFG--------QMPPLEPNWELISDGPAWAW---WIIALLPLSQQLKVDILATTSL 987
            ..|..:.|.|.|        .|.....::|::       |   :..:|.|:.:         ..|
Yeast   283 QSQIKQKLSSLGLSTNGTRQNMIKRYNHYEML-------WNSNFCDSLEPVDE---------AEL 331

  Fly   988 EKRLRAIDKTLDWLHDLSHPQQP 1010
            :::|      |.|  |:||.:.|
Yeast   332 KRQL------LSW--DVSHNKTP 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32369	NP_001246660.1	RING	183..>206	CDD:302633
		TPR_11	349..412	CDD:290150
		TPR repeat	350..378	CDD:276809
		TPR_11	383..449	CDD:290150
		TPR repeat	383..413	CDD:276809
		RING	687..729	CDD:238093	18/70 (26%)
		LON	791..1005	CDD:271862	44/236 (19%)
		LON_substr_bdg	802..1001	CDD:280370	38/221 (17%)
RAD18	NP_009992.1	RAD18	1..470	CDD:227719	89/413 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2251
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030