DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32369 and rnf169

DIOPT Version :9

Sequence 1:	NP_001246660.1	Gene:	CG32369 / 38873	FlyBaseID:	FBgn0052369	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	XP_001336012.2	Gene:	rnf169 / 795748	ZFINID:	ZDB-GENE-030131-4336	Length:	630	Species:	Danio rerio

Alignment Length:	185	Identity:	44/185 - (23%)
Similarity:	64/185 - (34%)	Gaps:	62/185 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   631 VDRAHAAGESQRCSRLFAGVLDRTQQELQRLKKLDKSAPSLAVSSVAGQLIDASDFDCVVCSRTL 695
            |..|.:.|..|| |:...|.|               |||           :...:..|.|||..|
Zfish     6 VGSAKSTGPGQR-SKSRPGAL---------------SAP-----------LSLEEARCPVCSEIL 43

  Fly   696 WKPVVTPCGHTYCLVCLDRCMDYNSPCPLCMSPLVEFNVNASASTSASQ---------------H 745
            .:||..||||:.||.|..|.:...|.|  |  ||....|::.|...:.:               |
Zfish    44 LEPVTMPCGHSVCLHCFQRTVKLISLC--C--PLCRLRVSSWARKQSREKSLVNAELWELVRLSH 104

  Fly   746 PNPNQNQIHLHPGSSSPVPFA-LAKRPVTKFLEAAMKRFIPDHYEARFRQEIDQE 799
            |...:.::....|.   :|.. :.:.||            |.|.....|||.:::
Zfish   105 PERCKRRMEQRDGE---IPDGEIFRAPV------------PVHKVGEMRQEYEKQ 144

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32369	NP_001246660.1	RING	183..>206	CDD:302633
		TPR_11	349..412	CDD:290150
		TPR repeat	350..378	CDD:276809
		TPR_11	383..449	CDD:290150
		TPR repeat	383..413	CDD:276809
		RING	687..729	CDD:238093	18/41 (44%)
		LON	791..1005	CDD:271862	3/9 (33%)
		LON_substr_bdg	802..1001	CDD:280370
rnf169	XP_001336012.2	RING	36..75	CDD:238093	20/42 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900