DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32369 and Lonrf3

DIOPT Version :9

Sequence 1:	NP_001246660.1	Gene:	CG32369 / 38873	FlyBaseID:	FBgn0052369	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	XP_006541467.1	Gene:	Lonrf3 / 74365	MGIID:	1921615	Length:	805	Species:	Mus musculus

Alignment Length:	1025	Identity:	257/1025 - (25%)
Similarity:	398/1025 - (38%)	Gaps:	314/1025 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 EQQDQGHHMPPSSPIQCYLPHNDSQNSLHYLL--AESFAKVGSLPEAFDVYELIASRQFDGHVPL 73
            ::.:|...:...:|::|.:           ||  |::.|..|.|.||.:||..::.||   .:..
Mouse    56 QEPEQSLPLAVPTPLECKV-----------LLTQADALASEGHLREALEVYRQLSERQ---QLVA 106

  Fly    74 DKLNTLASALTTHIRQMGGIATPTPTPTPTPMSAVHVKSPRISERLDMMPWSRYHHQGKQNQAEQ 138
            ::|..|...|.                                   |.:|           |.|.
Mouse   107 EQLEQLVRCLA-----------------------------------DSVP-----------QEEL 125

  Fly   139 GEFLRGVGE----SMDEAGDSPLDMHSPTRELRVPSPLQDLEDFDPLMCPLCSDILRCPVTTNCG 199
            .....|...    ::.|||           |....:|    |.:|...|..|...|..||:..||
Mouse   126 ASDSSGTSSCCAAALKEAG-----------EAAAVAP----EVWDGFKCKKCHGFLSDPVSLWCG 175

  Fly   200 HTFCRQCCE----TITQCNICQVRFPRIQASS---PGPPVCALTTTTASGAGSSLFTAPSNHNAN 257
            ||||:.|.|    ...:|.:|.|:...:.|:|   .||
Mouse   176 HTFCKLCLERGRAADRRCALCGVKLSALMAASGRARGP--------------------------- 213

  Fly   258 LSLISFPVGYGVQLSSSVQRLAAP-PMTVTTTTVASTTATATTTMASTSAAAALGLSAYPSAHGG 321
                              :|...| |:.:....|.|                            |
Mouse   214 ------------------RRAGQPAPLQLRVNVVLS----------------------------G 232

  Fly   322 GIGSTAMKFMPDVLVRRLVEKWWGPDLQAKKISEKASSCMHLNLLDDALKFCNASLEKSPANFKS 386
            .:|    |..|            || .:|.::..:.:.....:.::.||...|.::..:|.:...
Mouse   233 LLG----KLFP------------GP-ARASQLRHEGNRLFREHQVEAALLKYNEAVRLAPNDHLL 280

  Fly   387 LCLRAEVLLKLSHYQSSLADIENALRTRCTSPKAHYLRALALSGLGRLEEALYNGFLAICLDKKT 451
            ...|:::...|..::.:|.|.|.|.:.|....|||:.:|.||:.||:::|||......:.||.|.
Mouse   281 YSNRSQIYFTLESHEDALHDAEIACKLRPMGFKAHFRKAQALATLGKVKEALKEFLYCVSLDGKN 345

  Fly   452 NLSNSEIFQHDLAKILQRLLAHMPKNRTSLSSATVPVFQQQHR-NFATSRAPYPLLWEQVRRRRK 515
            ..:.||         .||||       .|..|.:||...|:|. :.....||:|.|.|.|.....
Mouse   346 KSARSE---------AQRLL-------FSFFSPSVPGESQEHSPDILKLLAPHPRLKEHVESMAT 394

  Fly   516 QQHHHHHHHHHHHVHLDDVEDEFGHYNNYIMAGDDMEEEVEVEVEGGEPGSLHLDGDFLFPSALD 580
            :      ...|:...|.....|..|.:|         :|.....|  |..||
Mouse   395 E------GTSHNLPKLSQENLELPHCSN---------QEGAAAAE--ESSSL------------- 429

  Fly   581 FMDHHRHQRHVFEQKQFDLQPRRHANRKHCKRKWSVAMESMGGKDLEEEDVDRAHA-AGESQRCS 644
                                    ||....|    |:.:....||.|.||.|.|.. .|:.|...
Mouse   430 ------------------------ANSAQGK----VSSKEDRKKDQEGEDRDAASVRTGKCQEKK 466

  Fly   645 RLFAGVLDRTQQELQ-------RLKKLDKSAPSLAVSSVAGQL--IDASDFDCVVCSRTLWKPVV 700
            |      :|.|.|.|       ::.|.|..|...|...::..|  .||||.:|.:|.|..::||.
Mouse   467 R------NRCQIETQEDTELPNKVSKQDFPAEQGAKPDLSNPLGSFDASDLECSLCMRLFYEPVT 525

  Fly   701 TPCGHTYCLVCLDRCMDYNSPCPLCMSPLVEFNVNASASTSASQHPNPNQNQIHLHPGSSSPVPF 765
            ||||||:||.||:||:|:|:.||||...|::
Mouse   526 TPCGHTFCLKCLERCLDHNAKCPLCKDVLLQ---------------------------------- 556

  Fly   766 ALAKRPVTK--FLEAAMKRFIPDHYEAR---FRQEIDQ----EPSVPVFICTAAFPAVPCPLFVC 821
            .|..|..:|  .||..:..|:|:.::.|   :.:|:::    ..:||:|:||.|:|.|||||.:.
Mouse   557 CLPSRKYSKNVILEELIATFLPEEFKERKRLYEEEMEELSNLNKNVPIFVCTMAYPTVPCPLHIF 621

  Fly   822 EPRYRLMVRRAVESGDKTFGIVQPNGGKSRYYDVGTILDIRDCVQLGDGCSILSTIGCKRFKILA 886
            ||.||||:||.:|:|.:.||:...:..|. :.:.|.||:||:.....||.|::.:||.:|||:|.
Mouse   622 EPCYRLMIRRCIETGTRQFGMCLGDPVKG-FVEYGCILEIRNVQFFSDGRSVVDSIGKRRFKVLH 685

  Fly   887 RNEKDGYETAKVEYICDEPIADEQVKILAGMQGVVLAKASEWFESLSTEQKHEILQSFGQMPPLE 951
            :.::|||.||.:|||.|:.:..:....|.|:...|..:||.||.||....|:.||..||.||..:
Mouse   686 QGQRDGYNTADIEYIEDQKVQGDDCAELMGLHNCVYEQASSWFHSLKASLKNRILNHFGPMPEKD 750

  Fly   952 PNWELISDGPAWAWWIIALLPLSQQLKVDILATTSLEKRLRAIDKTLDWL 1001
            .:.::..:||||.||.:|:|||..:.::..||..||:.||..|.:.|.::
Mouse   751 EDPQVNPNGPAWCWWTLAVLPLESRAQLPFLAMRSLKDRLNGIRRILAFI 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32369	NP_001246660.1	RING	183..>206	CDD:302633	11/22 (50%)
		TPR_11	349..412	CDD:290150	11/62 (18%)
		TPR repeat	350..378	CDD:276809	4/27 (15%)
		TPR_11	383..449	CDD:290150	19/65 (29%)
		TPR repeat	383..413	CDD:276809	6/29 (21%)
		RING	687..729	CDD:238093	23/41 (56%)
		LON	791..1005	CDD:271862	84/218 (39%)
		LON_substr_bdg	802..1001	CDD:280370	82/198 (41%)
Lonrf3	XP_006541467.1	RING1-HC_LONFs	159..197	CDD:319427	14/37 (38%)
		3a0801s09	<244..>359	CDD:273380	32/130 (25%)
		TPR repeat	244..272	CDD:276809	4/27 (15%)
		TPR repeat	277..307	CDD:276809	6/29 (21%)
		TPR repeat	312..335	CDD:276809	11/22 (50%)
		PEX10	<456..551	CDD:227861	38/100 (38%)
		RING2-HC_LONFs	510..551	CDD:319428	23/40 (58%)
		LON_substr_bdg	601..802	CDD:366967	82/201 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836294
Domainoid	1	1.000	177	1.000	Domainoid score	I3570
eggNOG	1	0.900	-	-		E1_COG2802
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	330	1.000	Inparanoid score	I2425
Isobase	1	0.950	-	0	Normalized mean entropy	S5222
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D207900at33208
OrthoFinder	1	1.000	-	-		FOG0001000
OrthoInspector	1	1.000	-	-		otm44341
orthoMCL	1	0.900	-	-		OOG6_101814
Panther	1	1.100	-	-	O	PTHR23327
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2251
SonicParanoid	1	1.000	-	-		X746
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.740