Protein Alignment CG32369 and lonrf2

DIOPT Version :10

• Sequence 1: NP_729296.1
• Gene: CG32369 / 38873
• FlyBaseID: FBgn0052369
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: XP_012812624.1
• Gene: lonrf2 / 733984
• XenbaseID: XB-GENE-6045285
• Length: 775
• Species: Xenopus tropicalis
• Alignment Length: 1026
• Identity: 249/1026 - (24%)
• Similarity: 393/1026 - (38%)
• Gaps: 319/1026 - (31%)

  Fly    20 PPSSPIQCYLPHNDSQNSLHYLLAESFAKVGSLPEAFDVYELIASRQFDGHVPLDKLNTLASALT 84
            ||:.|..|         |....:||...:.|:...|.::|......|....:.|.|.:.||.|
 Frog    13 PPAPPGLC---------SEMLGVAEESYRAGNFELAAEIYGSQLEEQPQRFLWLRKGDALALA-- 66

  Fly    85 THIRQMGGIATPTPTPTPTPMSAVHVKSPRISERLDMMPWSRYHHQGKQNQAEQGEFLRGVGESM 149
                                        .|:::.||.  ::|.....:....|.|..:..:..::
 Frog    67 ----------------------------GRVTDALDC--YTRAAMLSQLRPEELGVLVGSIARNI 101

  Fly   150 DE-------AGDSPLDMH---------SPTRELRVPSPLQDLEDFDPLMCPLCSDILRCPVTTNC 198
            .|       |...|...|         :|..|   |:|:.|:     ..||:|..:|..|||..|
 Frog   102 REKELGLPCAQREPGTAHPQYSVSPYSAPPAE---PTPISDI-----FSCPMCRLLLLDPVTLLC 158

  Fly   199 GHTFCRQC--CETITQCNICQVRFPRIQASSPGPPVCALTTTTASGAGSSLFTAPSNHNANLSLI 261
            ||:.|::|  .:...||:.|                           |..|
 Frog   159 GHSVCKRCLRAQEPLQCSQC---------------------------GDKL-------------- 182

  Fly   262 SFPVGYGVQLSSSVQRLAAPPMTVTTTTVASTTATATTTMASTSAAAALGLSAYPSAHGGGIGST 326
                                                            .|.:.:|       |.:
 Frog   183 ------------------------------------------------KGKAEWP-------GVS 192

  Fly   327 AMKFMPDVLVRRLVEKWWGPDLQAKKISEKASSCMHLNLLDDALKFCNASLE----KSPANFKSL 387
            .|....:|::..|::||...:.:.:::|.:.......:.|..|::..:|:||    .||.:....
 Frog   193 LMDSKVNVVLGNLLQKWLKEETKVRRLSVEGELLRESSNLMGAMEKYSAALELSKYPSPCDSWLA 257

  Fly   388 CLRAEVLLKLSHYQSSLADIENALRTRCTSPKAHYLRALALSGLGRLEEALYNGFLAICLDKKTN 452
            ..|||:.|.:.:|..:::|.:...:....|.|.||::|.|||||||.||||......:.|:.:.:
 Frog   258 AERAELYLAMKNYNQAISDADTVCKKEPLSHKGHYVKARALSGLGRTEEALKEFLYCVALNPEWS 322

  Fly   453 LSNSEIFQHDLAKILQRLLAHMPKNRTSLSSATVPVFQQQHRNFATSRAPYPLLWEQVRRRRKQQ 517
            |...|         .|:::..|          ..|.|:....:..|   |...|....|.:..
 Frog   323 LMKIE---------AQKIICEM----------LFPAFENVQASLGT---PLRALTSHTRLKPS-- 363

  Fly   518 HHHHHHHHHHHVHLDDVEDEFGHYNNYIMAGDDMEEEVEVEVEGGEPGSLHLDGDFLFPSALDFM 582
                                       :...:...|:..:      ||   ...|..|.....|:
 Frog   364 ---------------------------LTNSNTCTEDFSL------PG---CSKDSKFQITKSFV 392

  Fly   583 DHHRHQRHVFEQKQFDLQPRRHANRKHCKRKWSVAMESMG-------GKDLE-----EEDVDRAH 635
                 :..:|..::|..:|      ..|....|.|.||:|       |..|:     .||...|.
 Frog   393 -----ESDIFVMEEFKDEP------VSCMLPHSKAEESLGNVLVSLPGASLKRKLNSSEDYQSAT 446

  Fly   636 A----AGESQRCSRLFAGVLDRTQQELQRLKKLDKSAPSLAVSSVAGQLIDASDFDCVVCSRTLW 696
            |    .|...:|                     ::||..|.:..:...|:||.||:|.:|.|..:
 Frog   447 AKVRKTGAESKC---------------------EQSATKLVLRDIPVALVDACDFECSLCMRLFY 490

  Fly   697 KPVVTPCGHTYCLVCLDRCMDYNSPCPLCMSPLVEFNVNASASTSASQHPNPNQNQIHLHPGSSS 761
            :||.||||||:||.||:||:|:|..||||...|.::
 Frog   491 EPVATPCGHTFCLKCLERCLDHNPHCPLCKEDLAQY----------------------------- 526

  Fly   762 PVPFALAKRPVTKFL--EAAMKRFIPDH-------YEARFRQEIDQEPSVPVFICTAAFPAVPCP 817
                 ||.|...|.|  |..:.|::|:.       |:...::..:....||:|:||.|||.:|||
 Frog   527 -----LAYRAYKKTLLTEELITRYLPEELTERKKIYDEEMKELSNLHKDVPIFVCTMAFPTIPCP 586

  Fly   818 LFVCEPRYRLMVRRAVESGDKTFGIVQPNGGKSRYYDVGTILDIRDCVQLGDGCSILSTIGCKRF 882
            |.|.|||||||:||::|:|.|.||:...:..|. :.|.|.:|.:||.....||.|::.|||..||
 Frog   587 LHVFEPRYRLMIRRSMETGTKQFGMCIADDLKG-FADYGCMLQVRDVKFFPDGRSVVDTIGLNRF 650

  Fly   883 KILARNEKDGYETAKVEYICDEPIADEQVKILAGMQGVVLAKASEWFESLSTEQKHEILQSFGQM 947
            |:|:..::|||.||.:||:.|:.:..::.:.|..:...|..:|..||.||....|.:||..||||
 Frog   651 KVLSHGQRDGYNTANIEYLEDKKMEGQEYEELLVLHNSVYDQALGWFTSLKDNMKSQILSHFGQM 715

  Fly   948 PPLEPNWELISDGPAWAWWIIALLPLSQQLKVDILATTSLEKRLRAIDKTL 998
            |..|.:.:...:||||.||::|:|||..:.::.|||.|||:.||.||.:.|
 Frog   716 PSKESDPQNGENGPAWCWWMLAVLPLESKAQLTILAMTSLKDRLHAIKRIL 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32369	NP_729296.1	RING_Ubox	179..222	CDD:473075	15/44 (34%)
		TPR repeat	350..378	CDD:276809	4/27 (15%)
		TPR	357..>438	CDD:440225	27/84 (32%)
		Spy	363..>517	CDD:443119	40/157 (25%)
		TPR repeat	383..413	CDD:276809	6/29 (21%)
		RING-HC_LONFs_rpt2	685..729	CDD:438177	25/43 (58%)
		LON/PUA	811..999	CDD:442054	82/188 (44%)
lonrf2	XP_012812624.1	RING_Ubox	139..184	CDD:473075	18/138 (13%)
		TPR	223..>320	CDD:440225	30/96 (31%)
		TPR repeat	253..283	CDD:276809	6/29 (21%)
		TPR repeat	288..311	CDD:276809	15/22 (68%)
		RING-HC_LONFs_rpt2	479..523	CDD:438177	25/43 (58%)
		rad18	480..>570	CDD:273165	34/123 (28%)
		LON_substr_bdg	571..771	CDD:426647	88/197 (45%)