DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32369 and BFAR

DIOPT Version :9

Sequence 1:	NP_001246660.1	Gene:	CG32369 / 38873	FlyBaseID:	FBgn0052369	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	NP_057645.1	Gene:	BFAR / 51283	HGNCID:	17613	Length:	450	Species:	Homo sapiens

Alignment Length:	333	Identity:	72/333 - (21%)
Similarity:	109/333 - (32%)	Gaps:	108/333 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 SMDEAGDSPLDMHSPTRELRVPSPLQDLEDFDPLMCPLCSDILRCPVTTNCGHTFCRQC------ 206
            :||...|.|         |:...|...:.:|.   |..|.|||..|.|.||||:|||.|
Human    11 TMDLERDEP---------LKSTGPQISVSEFS---CHCCYDILVNPTTLNCGHSFCRHCLALWWA 63

  Fly   207 CETITQCNICQVR---FPRIQASSPGPPVCALTTTTASGAGSSLFTAPSNHNANLSLISFPVGYG 268
            ....|:|..|:.:   ||::             :.....|...||  |.........|.
Human    64 SSKKTECPECREKWEGFPKV-------------SILLRDAIEKLF--PDAIRLRFEDIQ------ 107

  Fly   269 VQLSSSVQRLAA---------PPMTVTTTTVASTTATATTTM----------ASTSAAAALGL-- 312
             |.:..||.|||         |        :|..|..|...|          |.|..|..|.:
Human   108 -QNNDIVQSLAAFQKYGNDQIP--------LAPNTGRANQQMGGGFFSGVLTALTGVAVVLLVYH 163

  Fly   313 -SAYPSAHGGGIGSTAMKFMPDVLVRRLVEKW--------------WGPDLQAKKISEKASSCMH 362
             |:..|.|             |:||.:.|.||              |....:.:.:||:.:..:.
Human   164 WSSRESEH-------------DLLVHKAVAKWTAEEVVLWLEQLGPWASLYRERFLSERVNGRLL 215

  Fly   363 LNLLDDALKFCNASLEKSPANFKSLCLRAEVLLKLSHYQS-SLADIENALRTRCTSPKAHYLRAL 426
            |.|.::       ...|:|...::...|..:|::|...:: .:...:|....:..:|........
Human   216 LTLTEE-------EFSKTPYTIENSSHRRAILMELERVKALGVKPPQNLWEYKAVNPGRSLFLLY 273

  Fly   427 ALSGLGRL 434
            ||....||
Human   274 ALKSSPRL 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32369	NP_001246660.1	RING	183..>206	CDD:302633	14/22 (64%)
		TPR_11	349..412	CDD:290150	10/63 (16%)
		TPR repeat	350..378	CDD:276809	4/27 (15%)
		TPR_11	383..449	CDD:290150	9/53 (17%)
		TPR repeat	383..413	CDD:276809	4/30 (13%)
		RING	687..729	CDD:238093
		LON	791..1005	CDD:271862
		LON_substr_bdg	802..1001	CDD:280370
BFAR	NP_057645.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		4/17 (24%)
		RING-HC_BAR	32..77	CDD:319411	19/47 (40%)
		RING-HC finger (C3HC4-type)	34..73	CDD:319411	17/38 (45%)
		SAM_BAR	179..249	CDD:188912	13/76 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900