DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32369 and Trim80

DIOPT Version :9

Sequence 1:	NP_001246660.1	Gene:	CG32369 / 38873	FlyBaseID:	FBgn0052369	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	NP_001028947.1	Gene:	Trim80 / 432613	MGIID:	3588186	Length:	624	Species:	Mus musculus

Alignment Length:	331	Identity:	67/331 - (20%)
Similarity:	113/331 - (34%)	Gaps:	76/331 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 DPLMCPLCSDILRCPVTTNCGHTFCRQCCETITQ----------CNICQVRFPRIQASSPGPPVC 233
            |.::||:|.::...||||.|||.||..|.:....          |..|:      :|.|..|.:|
Mouse    67 DQVLCPICLEVFCNPVTTACGHNFCMTCLQNFWDHQAAIGETYYCPQCR------EAFSSRPRLC 125

  Fly   234 ALTTTTASGAGSSLFTAPSNHNANLSLISFPVGYGVQLSSSVQRLAAPPMTVTTTTVASTTATAT 298
               .....|...:.||...:                |.|.|:..||.|      |.|.....:..
Mouse   126 ---KNVILGEMVACFTQAKS----------------QTSGSLWGLAGP------TDVPCDFCSPQ 165

  Fly   299 TTMASTSAAAALGLSAYPSAHGGGIGSTAMKFM----PDVLVR--RLVEKWWGPDLQAKKISEKA 357
            ...|:.|....             :.|...|.:    .|.|.:  :|::..|  || ..::..|.
Mouse   166 KLRAAKSCLQC-------------VASLCEKHLRSHFEDQLFQDHQLLDPVW--DL-TNRLCRKH 214

  Fly   358 SSCMHLNLLDDALKFCNASLEKSPANFKSLCLRAEVLLKLSHYQSSLADIENALRTRCTSPKAHY 422
            .....|....:....|.|.|.:...|..:..|..|...|....:...|::||.:....:..:.|.
Mouse   215 RKLRQLYCRTEGSCVCGACLLEEHKNHDTTPLEDERARKEVEVRKIQANVENQMLIIASDSQKHQ 279

  Fly   423 LRALALSGLGRLEEALYNGFLAICLDKKTNLSNSEIFQHDLAKILQRLLAHMPKNRTSLSSATVP 487
            .|   :|.|.:|.:.:.:         :.:...|||. |::.::..::|..:.|...:.......
Mouse   280 GR---VSFLSKLIQTMRD---------EVDTCFSEIL-HEIKQLQMKVLDFVEKEEAAALGKLGN 331

  Fly   488 VFQQQH 493
            ..||.|
Mouse   332 SIQQSH 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32369	NP_001246660.1	RING	183..>206	CDD:302633	12/22 (55%)
		TPR_11	349..412	CDD:290150	12/62 (19%)
		TPR repeat	350..378	CDD:276809	4/27 (15%)
		TPR_11	383..449	CDD:290150	12/65 (18%)
		TPR repeat	383..413	CDD:276809	7/29 (24%)
		RING	687..729	CDD:238093
		LON	791..1005	CDD:271862
		LON_substr_bdg	802..1001	CDD:280370
Trim80	NP_001028947.1	RING	71..114	CDD:302633	14/42 (33%)
		zf-B_box	208..246	CDD:279037	6/37 (16%)
		SPRY	444..620	CDD:295394
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2802
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900