Protein Alignment CG32369 and Lonrf2

DIOPT Version :10

• Sequence 1: NP_729296.1
• Gene: CG32369 / 38873
• FlyBaseID: FBgn0052369
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_001025049.2
• Gene: Lonrf2 / 381338
• MGIID: 1920209
• Length: 754
• Species: Mus musculus
• Alignment Length: 990
• Identity: 246/990 - (24%)
• Similarity: 362/990 - (36%)
• Gaps: 351/990 - (35%)

  Fly    42 LAESFAKVGSLPEAFDVYELIASRQFDGHVPLDKLNTLASALTTHIRQMGGIATPTPTPTPTPMS 106
            |.|:.|:.|.||||...:...|   ..|.:...:|:.|||.|.   |.:|
Mouse    62 LGEALARAGRLPEAIGAFRGAA---LLGPLQPGELSELASGLA---RALG--------------- 105

  Fly   107 AVHVKSPRISERLDMMPWSRYHHQGKQNQAEQGEFLRGVGESMDEAGDSPLDMHSPTRELRVPSP 171
             :..|.|.::.|                                     |....|     ..|.|
Mouse   106 -LREKRPPVAAR-------------------------------------PSGCAS-----GAPGP 127

  Fly   172 L--QDLEDFDPLMCPLCSDILRCPVTTNCGHTFCRQCCETITQCNICQVRFPRIQASSPGPPVCA 234
            :  :||     |.||.|..:|..|||.:.|.|.|::|.|.:                    ||.|
Mouse   128 VAPRDL-----LGCPRCGRLLYKPVTLSSGLTVCKRCVEQV--------------------PVRA 167

  Fly   235 LTTTTASGAGSSLFTAPSNHNANLSLISFPVGYGVQLSSSVQRLAAPPMTVTTTTVASTTATATT 299
            .....                            .|.||..::|.
Mouse   168 QARRV----------------------------NVMLSGLLERC--------------------- 183

  Fly   300 TMASTSAAAALGLSAYPSAHGGGIGSTAMKFMPDVLVRRLVEKWWGPDLQAKKISEKASSCMHLN 364
                                          |..:..:|||.       .||:.:..:...
Mouse   184 ------------------------------FPAECRLRRLA-------CQARGLHRQQQP----- 206

  Fly   365 LLDDALKFCNASLEKSPANFKSLCLRAEVLLKLSHYQSSLADIENALRTRCTSPKAHYLRALALS 429
              :.||..|..:|:.:|.:...|.||||:.|.:.:|..:|.|.|...:......|.|:::|..||
Mouse   207 --EAALLRCQQALDMAPDDNSLLLLRAELYLTMKNYDQALQDAEAVCQREPLLTKGHHIKAQILS 269

  Fly   430 GLGRLEEALYNGFLAICLDKKTNLSNSEIFQHDLAKILQRLLAHM------PKNRTSLSSATVPV 488
            ||||..|.|......:.|:.:.|.:..|         .|:::..:      .:::||.||
Mouse   270 GLGRHREVLKEFIYCLALNPECNSAKKE---------TQKVICEVFFSTSESEHQTSTSS----- 320

  Fly   489 FQQQHRNFATSRAPYPLLWEQVRRRRKQQHHHHHHHHHHHVHLDDVEDEFGHYNN---YIMAGDD 550
                     |...|..|...|...:...:....|.:..:.....:..|.....|:   |.:.|..
Mouse   321 ---------TETGPEALCEGQTNPQYPLEEAGGHANADNPKTPSEKSDAPADINSSVLYFILGLH 376

  Fly   551 MEEEVEVEVEGGEPGSLHLDGDFLFPSAL-------DFMDHHRHQRHVFE---QKQFDLQPRRHA 605
            .||:.:. :||..|.:         ||:.       |..|....:.:..|   :|..|..|:|:|
Mouse   377 CEEDKKA-LEGIVPAA---------PSSTLKRQLPSDAQDDEELKANTPEKIPKKDADSPPQRNA 431

  Fly   606 NRKHCKRKWSVAMESMGGKDLEEEDVDRAHAAGESQRCSRLFAGVLDRTQQELQRLKKLDKSAPS 670
            :                  .||||                                       |.
Mouse   432 S------------------SLEEE---------------------------------------PE 439

  Fly   671 LAVSSVAGQLIDASDFDCVVCSRTLWKPVVTPCGHTYCLVCLDRCMDYNSPCPLCMSPLVEFNVN 735
            ..        |||:||:|.:|.|.|::||.||||||:||.||:||:|:...||||...|.|.
Mouse   440 FT--------IDATDFECALCMRLLFEPVTTPCGHTFCLKCLERCLDHAPHCPLCKDKLSEL--- 493

  Fly   736 ASASTSASQHPNPNQNQIHLHPGSSSPVPFALAKR--PVTKFLEAAMKRFIPDHYEARFRQEIDQ 798
                                           ||.|  .||...|..:.|::||....| ::..|:
Mouse   494 -------------------------------LATRNFNVTVLTEELIFRYLPDELSDR-KRVYDE 526

  Fly   799 EPS--------VPVFICTAAFPAVPCPLFVCEPRYRLMVRRAVESGDKTFG--IVQPNGGKSRYY 853
            |.|        ||:|:|..|||.|||||.|.|||||||:||.:|:|.|.||  :...|.|.|.|
Mouse   527 EMSELSNLTRDVPIFVCAMAFPTVPCPLHVFEPRYRLMIRRCMETGTKRFGMCLSAENAGISEY- 590

  Fly   854 DVGTILDIRDCVQLGDGCSILSTIGCKRFKILARNEKDGYETAKVEYICDEPIADEQVKILAGMQ 918
              |.:|:|:|.....||.|::..||..||::|:...:|||.||.:||:.||.:...:.:.|..:.
Mouse   591 --GCMLEIKDVRTFPDGSSVVDAIGISRFRVLSHRHRDGYNTADIEYLEDEKVEGPEFEELTALH 653

  Fly   919 GVVLAKASEWFESLSTEQKHEILQSFGQMPPLEPNWELISDGPAWAWWIIALLPLSQQLKVDILA 983
            ..|..::..||.||....|.:||..||.||..||..:..|.||||:|||:|:|||.::.::.||.
Mouse   654 ESVYQQSVSWFASLQDHMKKQILSHFGSMPDREPEPQSNSSGPAWSWWILAVLPLERKAQLAILG 718

  Fly   984 TTSLEKRLRAIDKTL 998
            ..||::||.||.:.|
Mouse   719 MASLKERLLAIRRIL 733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32369	NP_729296.1	RING_Ubox	179..222	CDD:473075	13/42 (31%)
		TPR repeat	350..378	CDD:276809	4/27 (15%)
		TPR	357..>438	CDD:440225	25/80 (31%)
		Spy	363..>517	CDD:443119	38/159 (24%)
		TPR repeat	383..413	CDD:276809	10/29 (34%)
		RING-HC_LONFs_rpt2	685..729	CDD:438177	25/43 (58%)
		LON/PUA	811..999	CDD:442054	83/190 (44%)
Lonrf2	NP_001025049.2	TPR_16	27..90	CDD:433202	10/30 (33%)
		RING_Ubox	132..>162	CDD:473075	14/34 (41%)
		Spy	166..>290	CDD:443119	38/216 (18%)
		TPR repeat	223..253	CDD:276809	10/29 (34%)
		TPR repeat	258..281	CDD:276809	11/22 (50%)
		RING-HC_LONFs_rpt2	446..490	CDD:438177	25/43 (58%)
		LON/PUA	532..733	CDD:442054	87/203 (43%)