Protein Alignment CG32369 and Lonrf2

DIOPT Version :10

• Sequence 1: NP_729296.1
• Gene: CG32369 / 38873
• FlyBaseID: FBgn0052369
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: XP_006244931.1
• Gene: Lonrf2 / 301361
• RGDID: 1562137
• Length: 753
• Species: Rattus norvegicus
• Alignment Length: 1004
• Identity: 236/1004 - (23%)
• Similarity: 360/1004 - (35%)
• Gaps: 380/1004 - (37%)

  Fly    42 LAESFAKVGSLPEAFDVYELIASRQFDGHVPLDKLNTLASALTTHI----------RQMGGIATP 96
            |.|:.|:.|.||||...:...|   ..|.:...:|:.|||.|...:          .:.||.|:.
  Rat    62 LGEALARAGRLPEAIGAFRGAA---LLGPLQPGELSELASGLARALGLREKRPPVAARPGGCASG 123

  Fly    97 TPTPTPTPMSAVHVKSPRISERLDMMPWSRYHHQGKQNQAEQGEFLRGVGESMDEAGDSPLDMHS 161
            |..|.          :||
  Rat   124 TSGPV----------APR----------------------------------------------- 131

  Fly   162 PTRELRVPSPLQDLEDFDPLMCPLCSDILRCPVTTNCGHTFCRQCCETITQCNICQVRFPRIQAS 226
                             |.|.||.|..:|..|||.:.|.|.|::|.|.:
  Rat   132 -----------------DLLGCPRCGRLLYKPVTLSSGLTVCKRCVEQV---------------- 163

  Fly   227 SPGPPVCALTTTTASGAGSSLFTAPSNHNANLSLISFPVGYGVQLSSSVQRLAAPPMTVTTTTVA 291
                ||.|                                       ..:|:
  Rat   164 ----PVRA---------------------------------------QARRV------------- 172

  Fly   292 STTATATTTMASTSAAAALGLSAYPSAHGGGIGSTAMKFMPDVLVRRLVEKWWGPDLQAKKISEK 356
                                                     :|::..|:|:.:..:.:.::::.:
  Rat   173 -----------------------------------------NVVLSGLLERCFPAECRLRRLACQ 196

  Fly   357 ASSCMHLNLLDDALKFCNASLEKSPANFKSLCLRAEVLLKLSHYQSSLADIENALRTRCTSPKAH 421
            |.........:.||..|..:|:.:|.:...|.||||:.|.:.:|:.:|.|.:...:......|.|
  Rat   197 ARGLQRQQQPEAALLRCQQALDMAPDDSSLLLLRAELYLTMKNYEQALQDADTVCQREPLLTKGH 261

  Fly   422 YLRALALSGLGRLEEALYNGFLAICLDKKTNLSNSEIFQHDLAKILQRLLAHMPKNRTSLSSATV 486
            :::|..||||||.:|.|......:.|:.:.|.:..|     ..|::..:.....:|
  Rat   262 HIKAQILSGLGRNKEVLKEFIYCLALNPECNSAKKE-----TQKVICEVFFSASEN--------- 312

  Fly   487 PVFQQQHRNFATSRAPYPLLWEQVRRRRKQQHHHHHHHHHHHVHLDDVEDEFGHYNN-------- 543
               :||:...:|...|..|...|:..:                  :.:|:..||.|.
  Rat   313 ---EQQNSAPSTQTGPKALCDGQMSPQ------------------NPLEEAGGHANADSPKTPSE 356

  Fly   544 -------------YIMAGDDMEEEVEVEVEGGEP----GSLHLDGDFLFPSALDFMDHHRHQRHV 591
                         |.:.|...||:.:. :||..|    |:|...    .||..:..:...:....
  Rat   357 KPDVPENTNSSVLYFILGLHCEEDKKA-LEGVIPAAPSGTLKRQ----LPSDAEDKELDVNTPEK 416

  Fly   592 FEQKQFDLQPRRHANRKHCKRKWSVAMESMGGKDLEEEDVDRAHAAGESQRCSRLFAGVLDRTQQ 656
            ..:|..|..|:|:||                  .||||
  Rat   417 IPKKDADSSPQRNAN------------------SLEEE--------------------------- 436

  Fly   657 ELQRLKKLDKSAPSLAVSSVAGQLIDASDFDCVVCSRTLWKPVVTPCGHTYCLVCLDRCMDYNSP 721
                        |...        |||:||:|.:|.|.|::||.||||||:||.||:||:|:...
  Rat   437 ------------PEFT--------IDATDFECALCMRLLFEPVTTPCGHTFCLKCLERCLDHAPH 481

  Fly   722 CPLCMSPLVEFNVNASASTSASQHPNPNQNQIHLHPGSSSPVPFALAKR--PVTKFLEAAMKRFI 784
            ||||...|.|.                                  ||.|  .||...|..:.|::
  Rat   482 CPLCKDKLSEL----------------------------------LATRNFNVTVLTEELIFRYL 512

  Fly   785 PDHYEARFRQEIDQEPS--------VPVFICTAAFPAVPCPLFVCEPRYRLMVRRAVESGDKTFG 841
            ||....| ::..|:|.|        ||:|:|..|||.|||||.|.|||||||:||.:|:|.|.||
  Rat   513 PDELSDR-KRVYDEEMSELSHLTRDVPIFVCAMAFPTVPCPLHVFEPRYRLMIRRCMETGTKRFG 576

  Fly   842 --IVQPNGGKSRYYDVGTILDIRDCVQLGDGCSILSTIGCKRFKILARNEKDGYETAKVEYICDE 904
              :...|.|.|.|   |.:|:|:|.....||.|::..:|..||::|:...:|||.||.:||:.||
  Rat   577 MCLSAENAGISEY---GCMLEIKDVRTFPDGSSVVDAVGISRFRVLSHRHRDGYNTADIEYLEDE 638

  Fly   905 PIADEQVKILAGMQGVVLAKASEWFESLSTEQKHEILQSFGQMPPLEPNWELISDGPAWAWWIIA 969
            .:...:.:.|..:...|..::..||.||....|.:||..||.||..||..:..|.||||:|||:|
  Rat   639 KVEGAEFEELTALHESVYQQSVSWFASLQDHMKKQILSHFGSMPDREPEPQSNSSGPAWSWWILA 703

  Fly   970 LLPLSQQLKVDILATTSLEKRLRAIDKTL 998
            :|||.::.::.||...||::||.||.:.|
  Rat   704 VLPLERKAQLAILGMGSLKERLLAIRRIL 732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32369	NP_729296.1	RING_Ubox	179..222	CDD:473075	14/42 (33%)
		TPR repeat	350..378	CDD:276809	4/27 (15%)
		TPR	357..>438	CDD:440225	25/80 (31%)
		Spy	363..>517	CDD:443119	36/153 (24%)
		TPR repeat	383..413	CDD:276809	9/29 (31%)
		RING-HC_LONFs_rpt2	685..729	CDD:438177	25/43 (58%)
		LON/PUA	811..999	CDD:442054	82/190 (43%)
Lonrf2	XP_006244931.1	LapB	35..290	CDD:442196	70/417 (17%)
		RING_Ubox	132..>162	CDD:473075	13/29 (45%)
		TPR repeat	223..253	CDD:276809	9/29 (31%)
		TPR repeat	258..281	CDD:276809	11/22 (50%)
		COG5222	<308..563	CDD:227547	94/389 (24%)
		RING-HC_LONFs_rpt2	445..489	CDD:438177	25/43 (58%)
		LON/PUA	533..732	CDD:442054	86/201 (43%)