Protein Alignment CG32369 and Lonrf3

DIOPT Version :10

• Sequence 1: NP_729296.1
• Gene: CG32369 / 38873
• FlyBaseID: FBgn0052369
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: XP_006257509.1
• Gene: Lonrf3 / 298322
• RGDID: 1565451
• Length: 809
• Species: Rattus norvegicus
• Alignment Length: 1026
• Identity: 256/1026 - (24%)
• Similarity: 399/1026 - (38%)
• Gaps: 312/1026 - (30%)

  Fly    11 EQQDQGHHMPPSSPIQCYLPHNDSQNSLHYLL--AESFAKVGSLPEAFDVYELIASRQFDGHVPL 73
            ::.:|...:..|:|.:|.:           ||  |::.|..|.|.||.:||..::.||   .:..
  Rat    56 QEPEQSQPLAASTPPECKV-----------LLTQADALASRGHLREALEVYRQLSERQ---QLVA 106

  Fly    74 DKLNTLASALTTHIRQMGGIATPTPTPTPTPMSAVHVKSPRISERLDMMPWSRYHHQGKQNQAEQ 138
            ::|..|...|...|.| ..:..|.|. .|:..|:....:
  Rat   107 EQLEQLVRCLADSIPQ-DELMAPAPA-DPSATSSCCAAA-------------------------- 143

  Fly   139 GEFLRGVGESMDEAGDSPLDMHSPTRELRVPSPLQDLEDFDPLMCPLCSDILRCPVTTNCGHTFC 203
               |:..||:   |..:|                   |.:|...|..|...|..||:..||||||
  Rat   144 ---LKKAGEA---AAVAP-------------------EVWDGFKCRKCHGFLSDPVSLWCGHTFC 183

  Fly   204 RQCCE----TITQCNICQVRFPRIQASS---PGPPVCALTTTTASGAGSSLFTAPSNHNANLSLI 261
            :.|.|    ...:|.:|.|:...:..:|   .||
  Rat   184 KLCLERGRAADRRCALCGVKLSALMVASGRARGP------------------------------- 217

  Fly   262 SFPVGYGVQLSSSVQRLAAP--PMTVTTTTVASTTATATTTMASTSAAAALGLSAYPSAHGGGIG 324
                           |.:.|  |:.:....|.|                            |.:|
  Rat   218 ---------------RRSGPQAPLQLRVNVVLS----------------------------GLLG 239

  Fly   325 STAMKFMPDVLVRRLVEKWWGPDLQAKKISEKASSCMHLNLLDDALKFCNASLEKSPANFKSLCL 389
                |..|            || .:|.::..:.:.......::.||...|.::..:|.:......
  Rat   240 ----KLFP------------GP-ARASQLRHEGNRLYRERQVEAALLKYNEAVRLAPNDHLLYSN 287

  Fly   390 RAEVLLKLSHYQSSLADIENALRTRCTSPKAHYLRALALSGLGRLEEALYNGFLAICLDKKTNLS 454
            |:::...|..::.:|.|.|.|.:.|....|||:.:|.||:.||:::|||......:.||.|...:
  Rat   288 RSQIYFTLESHEDALHDAEIACKLRPMGFKAHFRKAQALATLGKVKEALREFLYCVSLDGKNKRA 352

  Fly   455 NSEIFQHDLAKILQRLLAHMPKNRTSLSSATVPVFQQQHR-NFATSRAPYPLLWEQVRRRRKQQH 518
            .||         .||||       .|..|.:||...|:|. :.....||:|.|.|.|.....:
  Rat   353 RSE---------AQRLL-------FSFFSPSVPGESQEHSPDILKLLAPHPRLKEHVESMATE-- 399

  Fly   519 HHHHHHHHHHVHLDDVEDEFGHYNNYIMAGDDMEEEVEVEVEGGEPGSLHLDGDFLFPSALDFMD 583
                ...|:...|.....|..|.:|...|....|....|.:..|:
  Rat   400 ----GTSHNLPKLSQENSELPHCSNQEGAAAREESSSLVNMAQGK-------------------- 440

  Fly   584 HHRHQRHVFEQKQFDLQPRRHANRKHCKRKWSVAMESMGGKDLEEEDVDRAHAAGESQRCSRLFA 648
                                 .:||..:           .|..|||:.|.|     |.|..:...
  Rat   441 ---------------------VSRKEDR-----------AKSQEEEEQDAA-----SVRTGKCLE 468

  Fly   649 GVLDRTQQELQ-------RLKKLDKSA-----PSLAVSSVAGQLIDASDFDCVVCSRTLWKPVVT 701
            ...:|.|.|.|       ::.|.|..|     |.|::...:   .||||.:|.:|.|..::||.|
  Rat   469 KKRNRCQIETQEDTELPNKVSKQDLPAEQGAKPDLSIPLGS---FDASDLECSLCMRLFYEPVTT 530

  Fly   702 PCGHTYCLVCLDRCMDYNSPCPLCMSPLVEFNVNASASTSASQHPNPNQNQIHLHPGSSSPVPFA 766
            |||||:||.||:||:|:|:.||||...|::                                  .
  Rat   531 PCGHTFCLKCLERCLDHNAKCPLCKDVLLQ----------------------------------C 561

  Fly   767 LAKRPVTK--FLEAAMKRFIPDHYEAR---FRQEIDQ----EPSVPVFICTAAFPAVPCPLFVCE 822
            |..|..:|  .:|..:.:|:|:..:.|   :.:|:::    ..:||:|:||.|:|.|||||.:.|
  Rat   562 LPSRKYSKNVIMEELIAKFLPEELKERRRLYEEEMEELSNLNKNVPIFVCTMAYPTVPCPLHIFE 626

  Fly   823 PRYRLMVRRAVESGDKTFGIV--QPNGGKSRYYDVGTILDIRDCVQLGDGCSILSTIGCKRFKIL 885
            |.||||:||.:|:|.|.||:.  .|..|.:.|   |.||:||:.....||.|::.:||.:|||:|
  Rat   627 PCYRLMIRRCIETGTKQFGMCLGDPVKGFAEY---GCILEIRNVQFFSDGRSVVDSIGKRRFKVL 688

  Fly   886 ARNEKDGYETAKVEYICDEPIADEQVKILAGMQGVVLAKASEWFESLSTEQKHEILQSFGQMPPL 950
            .:.::|||.||.:|||.|:.:..:....|.|:...|..:||.||.||.|..|:.||..||.||..
  Rat   689 HQGQRDGYNTADIEYIEDQKVQGDDCAELVGLHNCVYEQASSWFHSLKTSLKNRILNHFGPMPEK 753

  Fly   951 EPNWELISDGPAWAWWIIALLPLSQQLKVDILATTSLEKRLRAIDKTLDWL 1001
            :.:.::..:||||.||.:|:|||..:.::..||..||:.||..|.:.|.::
  Rat   754 DEDPQVNPNGPAWCWWTLAVLPLESRAQLPFLAMRSLKDRLNGIRRILAFI 804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32369	NP_729296.1	RING_Ubox	179..222	CDD:473075	17/46 (37%)
		TPR repeat	350..378	CDD:276809	4/27 (15%)
		TPR	357..>438	CDD:440225	20/80 (25%)
		Spy	363..>517	CDD:443119	43/154 (28%)
		TPR repeat	383..413	CDD:276809	6/29 (21%)
		RING-HC_LONFs_rpt2	685..729	CDD:438177	24/43 (56%)
		LON/PUA	811..999	CDD:442054	79/189 (42%)
Lonrf3	XP_006257509.1	RING-HC_LONFs_rpt1	159..207	CDD:438176	17/47 (36%)
		Spy	245..>364	CDD:443119	34/135 (25%)
		TPR repeat	248..276	CDD:276809	4/27 (15%)
		TPR repeat	281..311	CDD:276809	6/29 (21%)
		TPR repeat	316..339	CDD:276809	11/22 (50%)
		COG5222	<499..632	CDD:227547	54/169 (32%)
		RING-HC_LONFs_rpt2	514..558	CDD:438177	24/43 (56%)
		LON/PUA	615..803	CDD:442054	80/190 (42%)