Protein Alignment CG32369 and RNF168

DIOPT Version :10

• Sequence 1: NP_729296.1
• Gene: CG32369 / 38873
• FlyBaseID: FBgn0052369
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_689830.2
• Gene: RNF168 / 165918
• HGNCID: 26661
• Length: 571
• Species: Homo sapiens
• Alignment Length: 613
• Identity: 115/613 - (18%)
• Similarity: 193/613 - (31%)
• Gaps: 161/613 - (26%)

  Fly   171 PLQDLEDFDPLMCPLCSDILRCPVTTNCGHTFCRQCCE-TITQCNICQVRFPRIQASSPGPPVCA 234
            |...:.......|.:|.:||..|||..|.||.|:.|.: |:.:.::| ..|.|.:.||    ...
Human     4 PKDAIPSLSECQCGICMEILVEPVTLPCNHTLCKPCFQSTVEKASLC-CPFCRRRVSS----WTR 63

  Fly   235 LTTTTASGAGSSLFTAPSNHNANLSLISFPVGYGVQLSSSVQ--RLAAPPMTVTTTTVASTTATA 297
            ..|...|.....|:|....|......:........:::...|  ||.:.|..:........:..|
Human    64 YHTRRNSLVNVELWTIIQKHYPRECKLRASGQESEEVADDYQPVRLLSKPGELRREYEEEISKVA 128

  Fly   298 TTTMASTSAAAALGLSAYPSAHGGGIGSTAMKFMPDVLVRRLVEKWWGPDLQAKKISEKASSCMH 362
            ....||.                    ....|...:.:.|.|.|:    :.:.|:.:||....|.
Human   129 AERRASE--------------------EEENKASEEYIQRLLAEE----EEEEKRQAEKRRRAME 169

  Fly   363 LNLLDD---ALK-------FCNASLEKSPANF-KSLCLRAEVLLKLSHYQSSLADIENALRTRCT 416
            ..|..|   |.|       ||..|:..||.|. ||..:..:...|..:.|.:..||:..|..:..
Human   170 EQLKSDEELARKLSIDINNFCEGSISASPLNSRKSDPVTPKSEKKSKNKQRNTGDIQKYLTPKSQ 234

  Fly   417 SPKAHYLRAL-------------------------------ALS-----GLGR--LEEALYNGFL 443
            ...|.:..|:                               .||     |:|.  .:.::.:...
Human   235 FGSASHSEAVQEVRKDSVSKDIDSSDRKSPTGQDTEIEDMPTLSPQISLGVGEQGADSSIESPMP 299

  Fly   444 AICL---------DKKTNLSNSE----IFQHDLAKI---LQRLLAHMPKNRTSLSSA-TVPVFQQ 491
            .:|.         :.||..||..    :..|:..|.   ..:..|.||..||....| |..|.|.
Human   300 WLCACGAEWYHEGNVKTRPSNHGKELCVLSHERPKTRVPYSKETAVMPCGRTESGCAPTSGVTQT 364

  Fly   492 QHRNFATSRAPYP--LLWEQVRRRRKQQHHHHHHHHHHHVHLDDVEDEFGHYNNYIMAGDDMEEE 554
            ...|...:.....  |:.:::.:|:.|:.           ..:.|:|.........::.:...::
Human   365 NGNNTGETENEESCLLISKEISKRKNQES-----------SFEAVKDPCFSAKRRKVSPESSPDQ 418

  Fly   555 VEVEVEGGEPGSLHLDGDFLFPSALDFMDHHRHQRHVFE----------QKQFD---LQPRRH-- 604
            .|.|:.              |...|..::|...:||..|          ||:.|   :.|.|.
Human   419 EETEIN--------------FTQKLIDLEHLLFERHKQEEQDRLLALQLQKEVDKEQMVPNRQKG 469

  Fly   605 -ANRKHCKRKWSVAMESMGGKDLEEED------VDRAHAAGE-SQRCSRLFAGVLDRTQQELQRL 661
             .:..|.:...|...:.:.|:....:|      ....|...| ..|.......:..:.:|.:.|.
Human   470 SPDEYHLRATSSPPDKVLNGQRKNPKDGNFKRQTHTKHPTPERGSRDKNRQVSLKMQLKQSVNRR 534

  Fly   662 K---------KLDKSA----PSLAVSSV 676
            |         |:.|||    ||::..||
Human   535 KMPNSTRDHCKVSKSAHSLQPSISQKSV 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32369	NP_729296.1	RING_Ubox	179..222	CDD:473075	15/43 (35%)
		TPR repeat	350..378	CDD:276809	11/37 (30%)
		TPR	357..>438	CDD:440225	24/129 (19%)
		Spy	363..>517	CDD:443119	42/221 (19%)
		TPR repeat	383..413	CDD:276809	8/30 (27%)
		RING-HC_LONFs_rpt2	685..729	CDD:438177
		LON/PUA	811..999	CDD:442054
RNF168	NP_689830.2	RING-HC_RNF168	14..61	CDD:438212	18/51 (35%)
		UDM1_RNF168	110..183	CDD:409018	16/96 (17%)
		LR motif 1. /evidence=ECO:0000255|HAMAP-Rule:MF_03066	110..128		1/17 (6%)
		UMI motif. /evidence=ECO:0000255|HAMAP-Rule:MF_03066	143..151		1/7 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	151..174		6/26 (23%)
		MIU motif 1. /evidence=ECO:0000255|HAMAP-Rule:MF_03066	168..191		6/22 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	191..292		17/100 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	390..422		4/42 (10%)
		MIU2_RNF168	431..481	CDD:409266	10/49 (20%)
		MIU motif 2. /evidence=ECO:0000255|HAMAP-Rule:MF_03066	439..462		6/22 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	459..560		18/100 (18%)
		LR motif 2. /evidence=ECO:0000255|HAMAP-Rule:MF_03066	466..477		2/10 (20%)