DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG32369 and RNF168

DIOPT Version :9

Sequence 1:NP_001246660.1 Gene:CG32369 / 38873 FlyBaseID:FBgn0052369 Length:1066 Species:Drosophila melanogaster
Sequence 2:NP_689830.2 Gene:RNF168 / 165918 HGNCID:26661 Length:571 Species:Homo sapiens


Alignment Length:613 Identity:115/613 - (18%)
Similarity:193/613 - (31%) Gaps:161/613 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   171 PLQDLEDFDPLMCPLCSDILRCPVTTNCGHTFCRQCCE-TITQCNICQVRFPRIQASSPGPPVCA 234
            |...:.......|.:|.:||..|||..|.||.|:.|.: |:.:.::| ..|.|.:.||    ...
Human     4 PKDAIPSLSECQCGICMEILVEPVTLPCNHTLCKPCFQSTVEKASLC-CPFCRRRVSS----WTR 63

  Fly   235 LTTTTASGAGSSLFTAPSNHNANLSLISFPVGYGVQLSSSVQ--RLAAPPMTVTTTTVASTTATA 297
            ..|...|.....|:|....|......:........:::...|  ||.:.|..:........:..|
Human    64 YHTRRNSLVNVELWTIIQKHYPRECKLRASGQESEEVADDYQPVRLLSKPGELRREYEEEISKVA 128

  Fly   298 TTTMASTSAAAALGLSAYPSAHGGGIGSTAMKFMPDVLVRRLVEKWWGPDLQAKKISEKASSCMH 362
            ....||.                    ....|...:.:.|.|.|:    :.:.|:.:||....|.
Human   129 AERRASE--------------------EEENKASEEYIQRLLAEE----EEEEKRQAEKRRRAME 169

  Fly   363 LNLLDD---ALK-------FCNASLEKSPANF-KSLCLRAEVLLKLSHYQSSLADIENALRTRCT 416
            ..|..|   |.|       ||..|:..||.|. ||..:..:...|..:.|.:..||:..|..:..
Human   170 EQLKSDEELARKLSIDINNFCEGSISASPLNSRKSDPVTPKSEKKSKNKQRNTGDIQKYLTPKSQ 234

  Fly   417 SPKAHYLRAL-------------------------------ALS-----GLGR--LEEALYNGFL 443
            ...|.:..|:                               .||     |:|.  .:.::.:...
Human   235 FGSASHSEAVQEVRKDSVSKDIDSSDRKSPTGQDTEIEDMPTLSPQISLGVGEQGADSSIESPMP 299

  Fly   444 AICL---------DKKTNLSNSE----IFQHDLAKI---LQRLLAHMPKNRTSLSSA-TVPVFQQ 491
            .:|.         :.||..||..    :..|:..|.   ..:..|.||..||....| |..|.|.
Human   300 WLCACGAEWYHEGNVKTRPSNHGKELCVLSHERPKTRVPYSKETAVMPCGRTESGCAPTSGVTQT 364

  Fly   492 QHRNFATSRAPYP--LLWEQVRRRRKQQHHHHHHHHHHHVHLDDVEDEFGHYNNYIMAGDDMEEE 554
            ...|...:.....  |:.:::.:|:.|:.           ..:.|:|.........::.:...::
Human   365 NGNNTGETENEESCLLISKEISKRKNQES-----------SFEAVKDPCFSAKRRKVSPESSPDQ 418

  Fly   555 VEVEVEGGEPGSLHLDGDFLFPSALDFMDHHRHQRHVFE----------QKQFD---LQPRRH-- 604
            .|.|:.              |...|..::|...:||..|          ||:.|   :.|.|.  
Human   419 EETEIN--------------FTQKLIDLEHLLFERHKQEEQDRLLALQLQKEVDKEQMVPNRQKG 469

  Fly   605 -ANRKHCKRKWSVAMESMGGKDLEEED------VDRAHAAGE-SQRCSRLFAGVLDRTQQELQRL 661
             .:..|.:...|...:.:.|:....:|      ....|...| ..|.......:..:.:|.:.|.
Human   470 SPDEYHLRATSSPPDKVLNGQRKNPKDGNFKRQTHTKHPTPERGSRDKNRQVSLKMQLKQSVNRR 534

  Fly   662 K---------KLDKSA----PSLAVSSV 676
            |         |:.|||    ||::..||
Human   535 KMPNSTRDHCKVSKSAHSLQPSISQKSV 562

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32369NP_001246660.1 RING 183..>206 CDD:302633 11/22 (50%)
TPR_11 349..412 CDD:290150 20/73 (27%)
TPR repeat 350..378 CDD:276809 11/37 (30%)
TPR_11 383..449 CDD:290150 15/113 (13%)
TPR repeat 383..413 CDD:276809 8/30 (27%)
RING 687..729 CDD:238093
LON 791..1005 CDD:271862
LON_substr_bdg 802..1001 CDD:280370
RNF168NP_689830.2 RING 15..58 CDD:238093 16/43 (37%)
LR motif 1. /evidence=ECO:0000255|HAMAP-Rule:MF_03066 110..128 1/17 (6%)
UMI motif. /evidence=ECO:0000255|HAMAP-Rule:MF_03066 143..151 1/7 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 151..174 6/26 (23%)
MIU motif 1. /evidence=ECO:0000255|HAMAP-Rule:MF_03066 168..191 6/22 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 191..292 17/100 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 390..422 4/42 (10%)
MIU motif 2. /evidence=ECO:0000255|HAMAP-Rule:MF_03066 439..462 6/22 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 459..560 18/100 (18%)
LR motif 2. /evidence=ECO:0000255|HAMAP-Rule:MF_03066 466..477 2/10 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2802
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D458276at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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