DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG32369 and LONRF2

DIOPT Version :10

Sequence 1:NP_729296.1 Gene:CG32369 / 38873 FlyBaseID:FBgn0052369 Length:1066 Species:Drosophila melanogaster
Sequence 2:NP_940863.3 Gene:LONRF2 / 164832 HGNCID:24788 Length:754 Species:Homo sapiens


Alignment Length:981 Identity:248/981 - (25%)
Similarity:378/981 - (38%) Gaps:335/981 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 LAESFAKVGSLPEAFDVYELIASRQFDGHVPLDKLNTLASALTTHIRQMGGIATPTPTPTPTPMS 106
            |.::.|:.|.||||...:...|..   |.:..::|..||..|   :|.:|        ....|:|
Human    64 LGDALARAGRLPEALGAFRGAARL---GALRPEELEELAGGL---VRAVG--------LRDRPLS 114

  Fly   107 AVHVKSPRISERLDMMPWSRYHHQGKQNQAEQGEFLRGVGESMDEAGDSPLDMHSPTRELRVPSP 171
            |   ::|                             .|..|:..|.|.:|        |.|.|. 
Human   115 A---ENP-----------------------------GGEPEAPGEGGPAP--------EPRAPR- 138

  Fly   172 LQDLEDFDPLMCPLCSDILRCPVTTNCGHTFCRQCCETITQCNICQVRFPRIQASSPGPPVCALT 236
                   |.|.||.|..:|..|||..||.|.|::|.|                   |||      
Human   139 -------DLLGCPRCRRLLHKPVTLPCGLTVCKRCVE-------------------PGP------ 171

  Fly   237 TTTASGAGSSLFTAPSNHNANLSLISFPVGYGVQLSSSVQRLAAPPMTVTTTTVASTTATATTTM 301
                                              ....|:|:                       
Human   172 ----------------------------------ARPQVRRV----------------------- 179

  Fly   302 ASTSAAAALGLSAYPSAHGGGIGSTAMKFMPDVLVRRLVEKWWGPDLQAKKISEKASSCMHLNLL 366
                                           :|::..|:||.:..:.:.::::.:|.|.......
Human   180 -------------------------------NVVLSGLLEKCFPAECRLRRLAGQARSLQRQQQP 213

  Fly   367 DDALKFCNASLEKSPANFKSLCLRAEVLLKLSHYQSSLADIENALRTRCTSPKAHYLRALALSGL 431
            :.||..|:.:||.:|.:...|.||||:.|.:.:|:.:|.|...|.:......|.|.::|.|||||
Human   214 EAALLRCDQALELAPDDNSLLLLRAELYLTMKNYEQALQDASAACQNEPLLIKGHQVKAQALSGL 278

  Fly   432 GRLEEALYNGFLAICLDKKTNLSNSEIFQHDLAKILQRLLAHMPKNRTSLSSATVPVFQQQHRNF 496
            ||.:|.|......:.|:.:.|         .:.|..|:::..:      |.|||..|    |.|.
Human   279 GRSKEVLKEFLYCLALNPECN---------SVKKEAQKVMCEV------LFSATANV----HENL 324

  Fly   497 ATSRAPYPLLWEQVRRRRKQQHHHHHHHH--------HHHVHLDDVEDEFGHYNN---YIMAGDD 550
            .:|          ::.|.|.|.|.|.:..        ....:..:..|..|:.|:   |.:.|..
Human   325 TSS----------IQSRLKAQGHSHMNAQALLEEGDAGSSENSSEKSDMLGNTNSSVLYFILGLH 379

  Fly   551 MEEEVEVEVEGGEPGSLHLDGDFLFPSALDFMDHHRHQRHVFEQKQFDLQPRRHANRKHCKRKWS 615
            .||:.:..             :.:.|:|                                     
Human   380 FEEDKKAL-------------ESILPTA------------------------------------- 394

  Fly   616 VAMESMGGKDLEEEDVDRA---HAAGESQRCSRLFAGVLDRTQQELQRLKKLDKSAPSLAVSSVA 677
               .|.|.|....:||:.|   :|.|:           :.:....|||       :|:.......
Human   395 ---PSAGLKRQFPDDVEDAPDLNAPGK-----------IPKKDLSLQR-------SPNSETEESQ 438

  Fly   678 GQLIDASDFDCVVCSRTLWKPVVTPCGHTYCLVCLDRCMDYNSPCPLCMSPLVEFNVNASASTSA 742
            |..:|.:||:|.:|.|.|::||.||||||:||.||:||:|:...||||...|.|.        .|
Human   439 GLSLDVTDFECALCMRLLFEPVTTPCGHTFCLKCLERCLDHAPHCPLCKDKLSEL--------LA 495

  Fly   743 SQHPNPNQNQIHLHPGSSSPVPFALAKRPVTKFLEAAMKRFIPDHYEARFRQEIDQEPS------ 801
            |::.|                        :|...|..:.|::||....| ::..|:|.|      
Human   496 SRNFN------------------------ITVLAEELIFRYLPDELSDR-KRIYDEEMSELSNLT 535

  Fly   802 --VPVFICTAAFPAVPCPLFVCEPRYRLMVRRAVESGDKTFG--IVQPNGGKSRYYDVGTILDIR 862
              ||:|:|..|||.|||||.|.|||||||:||.:|:|.|.||  :...:.|.|.|   |.:|:|:
Human   536 RDVPIFVCAMAFPTVPCPLHVFEPRYRLMIRRCMETGTKRFGMCLSAEHAGLSEY---GCMLEIK 597

  Fly   863 DCVQLGDGCSILSTIGCKRFKILARNEKDGYETAKVEYICDEPIADEQVKILAGMQGVVLAKASE 927
            |.....||.|::..||..||::|:...:|||.||.:||:.||.:...:.:.||.:...|..::..
Human   598 DVRTFPDGSSVVDAIGISRFRVLSHRHRDGYNTADIEYLEDEKVEGPEYEELAALHDSVHQQSVS 662

  Fly   928 WFESLSTEQKHEILQSFGQMPPLEPNWELISDGPAWAWWIIALLPLSQQLKVDILATTSLEKRLR 992
            ||.||....|.:||..||.||..||..:....||||:|||:|:|||.::.::.||..|||::||.
Human   663 WFASLQDRMKEQILSHFGVMPDREPEPQSNPSGPAWSWWILAVLPLERKAQLAILGMTSLKERLL 727

  Fly   993 AIDKTL 998
            ||.:.|
Human   728 AIRRIL 733

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32369NP_729296.1 RING_Ubox 179..222 CDD:473075 15/42 (36%)
TPR repeat 350..378 CDD:276809 5/27 (19%)
TPR 357..>438 CDD:440225 29/80 (36%)
Spy 363..>517 CDD:443119 42/153 (27%)
TPR repeat 383..413 CDD:276809 10/29 (34%)
RING-HC_LONFs_rpt2 685..729 CDD:438177 25/43 (58%)
LON/PUA 811..999 CDD:442054 83/190 (44%)
LONRF2NP_940863.3 TPR 1 23..58
TPR_16 27..92 CDD:433202 9/30 (30%)
TPR 2 59..91 9/29 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 112..136 10/63 (16%)
RING-HC_LONFs_rpt1 139..>173 CDD:438176 18/92 (20%)
TPR 3 197..230 8/32 (25%)
TPR repeat 200..225 CDD:276809 5/24 (21%)
Spy 204..>297 CDD:443119 31/92 (34%)
TPR repeat 230..260 CDD:276809 10/29 (34%)
TPR 4 231..264 10/32 (31%)
TPR repeat 265..293 CDD:276809 12/27 (44%)
TPR 5 266..298 13/31 (42%)
PEX10 <380..489 CDD:227861 43/179 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 398..439 11/58 (19%)
RING-HC_LONFs_rpt2 446..490 CDD:438177 25/43 (58%)
TPR 6 447..483 20/35 (57%)
LON/PUA 532..733 CDD:442054 87/203 (43%)
Blue background indicates that the domain is not in the aligned region.

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