DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32369 and lonrf1

DIOPT Version :9

Sequence 1:	NP_001246660.1	Gene:	CG32369 / 38873	FlyBaseID:	FBgn0052369	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	XP_002934710.2	Gene:	lonrf1 / 100486729	XenbaseID:	XB-GENE-5900444	Length:	684	Species:	Xenopus tropicalis

Alignment Length:	948	Identity:	226/948 - (23%)
Similarity:	344/948 - (36%)	Gaps:	332/948 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 VKSPRISERLDMMPWSRYHHQGKQNQAEQGEFLRGVGESMDEAGDSPLDMHSPTRELRVPSPLQ- 173
            :.||.:.   |.:||.|                            ..||.|||:.    |.|.|
Frog     1 MSSPAVR---DGIPWLR----------------------------ELLDSHSPSN----PRPRQL 30

  Fly   174 ---------------------DLEDFD-PLMCPLCSDILRCPVTTNCGHTFCRQCC---ETITQC 213
                                 .||:.. ||.||.|...||.||:|.||||:|| ||   |..::|
Frog    31 GALLEYLVQKYSSWAAGGTVSRLEEGTFPLSCPGCGGFLREPVSTQCGHTYCR-CCLRGEPRSRC 94

  Fly   214 NICQVRFPRIQASSPGPPVCALTTTTASGAGSSLFTAPSNHNANLSLISFPVGYGVQLSSSVQRL 278
            .:|:....|
Frog    95 RLCREDMGR-------------------------------------------------------- 103

  Fly   279 AAPPMTVTTTTVASTTATATTTMASTSAAAALGLSAYPSAHGGGIGSTAMKFMPDVLVRRLVEKW 343
             :|..|.                                                ||:::|.:||
Frog   104 -SPRRTC------------------------------------------------VLLQQLADKW 119

  Fly   344 WGPDLQAKK-ISEKASSCMHLNLLDDALKFCNASLEKSPANFKSLCLRAEVLLKLSHYQSSLADI 407
            :.|.|..|. ..::....:......:||......:|..|.:......||:....|..:..:..|:
Frog   120 FPPLLGTKSDRDDEVRQLLGAGAYAEALHSVERFMETDPDDLMLHVYRADSYAGLCEFGKAHDDL 184

  Fly   408 ENALRTRCTSPKAHYLRALALSGLGRLEEALYNGFLAICLDKKTNLSNSEIFQHDLAKILQRLLA 472
            :..|..:...|:.:|.:|..|.....:.|:|......:.||:....:.||:     .|||...|:
Frog   185 DFVLSMQNNWPEVYYKKAKILQDSRHMYESLTFYLKTLALDETYEPARSEV-----EKILSDFLS 244

  Fly   473 HMPK---------NRTSLSSATVPVFQQQHRNFATSRAPYPLLWEQVRRRRKQQHHHHHHHHHHH 528
            ....         .||||.::.:..|
Frog   245 PAQDTVEGILKDLERTSLPNSQLKPF--------------------------------------- 270

  Fly   529 VHLDDVEDEFGHYNNYIMAGDDMEEEVEVEVEGGEPGSLHLDGDFLFPSALDFMDHHRHQRHVFE 593
            |...|.||.     .|.:...:..|||....:.....||                |.....|...
Frog   271 VLGADKEDV-----AYDLQNSEQHEEVPETAKNFSRSSL----------------HRTSSAHTIR 314

  Fly   594 QKQFDLQPRRHANRKHCKRKWSVAMESMGGKDLEEEDVDRAHAAG--ESQRCSRLFAGVLDRTQQ 656
            .     :||                       .|:|.:.|..:..  .||....|.......::|
Frog   315 S-----EPR-----------------------TEDESLKRVTSEPLLRSQETGVLLKRKFSFSEQ 351

  Fly   657 ELQ-----RLKKLDKSAPSLAV---SSVAGQLIDASDFDCVVCSRTLWKPVVTPCGHTYCLVCLD 713
            :..     |.|::.:..||..|   .|::..|||..||:|.:|.|..::||.||||||:|..||:
Frog   352 DASVCEDGRKKQIKQGEPSQLVFHGKSISDTLIDVVDFECSLCMRLFYEPVTTPCGHTFCKKCLE 416

  Fly   714 RCMDYNSPCPLCMSPLVEFNVNASASTSASQHPNPNQNQIHLHPGSSSPVPFALAKRP--VTKFL 776
            ||:|:...||||...|.||                                  ||||.  ||..|
Frog   417 RCLDHTPHCPLCKESLSEF----------------------------------LAKRSYNVTHLL 447

  Fly   777 EAAMKRFIPDHYEARFRQEIDQE---------PSVPVFICTAAFPAVPCPLFVCEPRYRLMVRRA 832
            |..:|.::|:  |...|:.:.:|         .:||:|:||.::|.|||||.|.|||||||:||.
Frog   448 EYLIKIYLPE--ELLERKRVHEEETAEFSNLTKNVPIFVCTMSYPTVPCPLHVFEPRYRLMIRRC 510

  Fly   833 VESGDKTFG--IVQPNGGKSRYYDVGTILDIRDCVQLGDGCSILSTIGCKRFKILARNEKDGYET 895
            :|:|.|.||  |..|   ::.:.|.|.:|.||:...|.||.|::.|:|.|||::|.|..:|||.|
Frog   511 METGTKQFGMCISDP---ENSFADYGCMLQIRNVHFLPDGRSVVDTVGGKRFRVLTRGMRDGYCT 572

  Fly   896 AKVEYICDEPIADEQVKILAGMQGVVLAKASEWFESLSTEQKHEILQSFGQMPPLEPNWELISDG 960
            |.:||:.|..:..|:.:.|..:...|.|:|..||::|....:.:||..||.||....:.:.:.:|
Frog   573 ADIEYLSDIQVNLEEFQQLKELHDAVHAQACRWFQNLRNRFRSQILHHFGAMPETGADIQAVPNG 637

  Fly   961 PAWAWWIIALLPLSQQLKVDILATTSLEKRLRAIDKTL 998
            |||.||::|:||:..:.::.:|:..||::||..:...|
Frog   638 PAWCWWLLAVLPVDPRYQLSVLSMMSLKERLLKLQHIL 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32369	NP_001246660.1	RING	183..>206	CDD:302633	14/22 (64%)
		TPR_11	349..412	CDD:290150	9/63 (14%)
		TPR repeat	350..378	CDD:276809	3/28 (11%)
		TPR_11	383..449	CDD:290150	12/65 (18%)
		TPR repeat	383..413	CDD:276809	5/29 (17%)
		RING	687..729	CDD:238093	21/41 (51%)
		LON	791..1005	CDD:271862	83/219 (38%)
		LON_substr_bdg	802..1001	CDD:280370	81/199 (41%)
lonrf1	XP_002934710.2	RING1-HC_LONFs	62..98	CDD:319427	18/36 (50%)
		TPR repeat	160..190	CDD:276809	5/29 (17%)
		TPR repeat	195..223	CDD:276809	6/27 (22%)
		RING2-HC_LONFs	388..429	CDD:319428	22/40 (55%)
		LON_substr_bdg	479..676	CDD:396663	81/200 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D207900at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010